mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PARG
Gene summary
Basic gene Info.Gene symbolPARG
Gene namepoly (ADP-ribose) glycohydrolase
SynonymsPARG99
CytomapUCSC genome browser: 10q11.23
Type of geneprotein-coding
RefGenesNM_003631.2,
Descriptionmitochondrial poly(ADP-ribose) glycohydrolasepoly(ADP-ribose) glycohydrolasepoly(ADP-ribose) glycohydrolase 60 kDa isoform
Modification date20141207
dbXrefs MIM : 603501
HGNC : HGNC
Ensembl : ENSG00000227345
HPRD : 04611
Vega : OTTHUMG00000018201
ProteinUniProt: Q86W56
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PARG
BioGPS: 8505
PathwayNCI Pathway Interaction Database: PARG
KEGG: PARG
REACTOME: PARG
Pathway Commons: PARG
ContextiHOP: PARG
ligand binding site mutation search in PubMed: PARG
UCL Cancer Institute: PARG
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for PARG
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
G751L752VCOAD1
T725T725IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PARG
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G751L752V-0.8347521
T725T725I-0.28097411
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PARG from PDB

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Differential gene expression and gene-gene network for PARG
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PARG and the right PPI network was created from samples without mutations in the LBS of PARG. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PARG
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0752351Embryo Loss1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PARG
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PARG go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE5a7rAG751
A8P8-N-OCTYLAMINO-ADENOSINE DIPHOSPHATE HYDROXYPYRROLIDINEDIOL4b1iAT725
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE5a7rAT725


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Conservation information for LBS of PARG
Multiple alignments for Q86W56 in multiple species
LBSAA sequence# speciesSpecies
A750GGVTSAGLVQE2Homo sapiens, Bos taurus
A750GGVLGHGCVQE1Drosophila melanogaster
A750GGVTGAGLVQE1Rattus norvegicus
A874NWGCGAFGGDA3Homo sapiens, Rattus norvegicus, Bos taurus
A874NWGCGAFGGDS1Drosophila melanogaster
C872TGNWGCGAFGG4Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Bos taurus
D487VTIRVDLLRAG1Homo sapiens
D487-----------1Drosophila melanogaster
D487VTVRVDLLRAG1Rattus norvegicus
D487VTIRVDLLRIG1Bos taurus
E727YEGTIEENGQG1Homo sapiens
E727AEGTIEDEGIG1Drosophila melanogaster
E727YEGTIEGNGRG1Rattus norvegicus
E727YEGTIEGNGQG1Bos taurus
F498EVPKPFPTHYK2Homo sapiens, Rattus norvegicus
F498--PRPYKSPGK1Drosophila melanogaster
F498EVPKPFPTHFK1Bos taurus
F738MLQVDFANRFV3Homo sapiens, Rattus norvegicus, Bos taurus
F738LLQVDFANKYL1Drosophila melanogaster
F875WGCGAFGGDAR3Homo sapiens, Rattus norvegicus, Bos taurus
F875WGCGAFGGDSY1Drosophila melanogaster
F902VVYFTFGDSEL3Homo sapiens, Rattus norvegicus, Bos taurus
F902LAYYTFGNVEF1Drosophila melanogaster
G745NRFVGGGVTSA2Homo sapiens, Bos taurus
G745NKYLGGGVLGH1Drosophila melanogaster
G745NRFVGGGVTGA1Rattus norvegicus
G751GVTSAGLVQEE2Homo sapiens, Bos taurus
G751GVLGHGCVQEE1Drosophila melanogaster
G751GVTGAGLVQEE1Rattus norvegicus
G871ATGNWGCGAFG4Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Bos taurus
G873GNWGCGAFGGD4Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Bos taurus
I484NHTVTIRVDLL2Homo sapiens, Bos taurus
I484-----------1Drosophila melanogaster
I484SHTVTVRVDLL1Rattus norvegicus
I726TYEGTIEENGQ1Homo sapiens
I726DAEGTIEDEGI1Drosophila melanogaster
I726TYEGTIEGNGR1Rattus norvegicus
I726TYEGTIEGNGQ1Bos taurus
N740QVDFANRFVGG3Homo sapiens, Rattus norvegicus, Bos taurus
N740QVDFANKYLGG1Drosophila melanogaster
N869AVATGNWGCGA3Homo sapiens, Rattus norvegicus, Bos taurus
N869GVATGNWGCGA1Drosophila melanogaster
P476LPLLRPSANHT1Homo sapiens
P476-----------1Drosophila melanogaster
P476LPLLRPSASHT1Rattus norvegicus
P476LPPLRPSANHT1Bos taurus
R485HTVTIRVDLLR2Homo sapiens, Bos taurus
R485-----------1Drosophila melanogaster
R485HTVTVRVDLLR1Rattus norvegicus
R663DINFNRLFEGR3Homo sapiens, Rattus norvegicus, Bos taurus
R663DINFNRLYQST1Drosophila melanogaster
S749GGGVTSAGLVQ2Homo sapiens, Bos taurus
S749GGGVLGHGCVQ1Drosophila melanogaster
S749GGGVTGAGLVQ1Rattus norvegicus
T725VTYEGTIEGNG2Rattus norvegicus, Bos taurus
T725VTYEGTIEENG1Homo sapiens
T725VDAEGTIEDEG1Drosophila melanogaster
V482SANHTVTIRVD2Homo sapiens, Bos taurus
V482-----------1Drosophila melanogaster
V482SASHTVTVRVD1Rattus norvegicus
V486TVTIRVDLLRA1Homo sapiens
V486-----------1Drosophila melanogaster
V486TVTVRVDLLRA1Rattus norvegicus
V486TVTIRVDLLRI1Bos taurus
Y795SEYTGYAETYR3Homo sapiens, Rattus norvegicus, Bos taurus
Y795SNYTGYAGSFE1Drosophila melanogaster


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