mutLBSgeneDB |
Gene summary for HIST1H2BK |
Gene summary |
Basic gene Info. | Gene symbol | HIST1H2BK |
Gene name | histone cluster 1, H2bk | |
Synonyms | H2B/S|H2BFAiii|H2BFT|H2BK | |
Cytomap | UCSC genome browser: 6p21.33 | |
Type of gene | protein-coding | |
RefGenes | NM_080593.2, | |
Description | H2B KH2B histone family, member THIRA-interacting protein 1histone 1, H2bkhistone H2B type 1-Khistone family member | |
Modification date | 20141217 | |
dbXrefs | MIM : 615045 | |
HGNC : HGNC | ||
HPRD : 13658 | ||
Protein | UniProt: O60814 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HIST1H2BK | |
BioGPS: 85236 | ||
Pathway | NCI Pathway Interaction Database: HIST1H2BK | |
KEGG: HIST1H2BK | ||
REACTOME: HIST1H2BK | ||
Pathway Commons: HIST1H2BK | ||
Context | iHOP: HIST1H2BK | |
ligand binding site mutation search in PubMed: HIST1H2BK | ||
UCL Cancer Institute: HIST1H2BK | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0002227 | innate immune response in mucosa | 12860195 | GO:0019731 | antibacterial humoral response | 12860195 | GO:0050830 | defense response to Gram-positive bacterium | 12860195 |
Top |
Ligand binding site mutations for HIST1H2BK |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | S57 | S57C | HNSC | 1 | E36 | E36K | SKCM | 1 | R87 | K86E | STAD | 1 | V40 | V40I | STAD | 1 | G54 | G54D | THCA | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for HIST1H2BK |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | V40 | V40I | -0.99703808 | E36 | E36K | -0.92217044 | G54 | G54D | -0.67344163 | S57 | S57C | -0.49389515 | R87 | K86E | -0.45994196 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for HIST1H2BK from PDB |
Top |
Differential gene expression and gene-gene network for HIST1H2BK |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for HIST1H2BK |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C1458155 | Breast Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for HIST1H2BK |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of HIST1H2BK go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of HIST1H2BK |
Multiple alignments for O60814 in multiple species |
LBS | AA sequence | # species | Species |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |