mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CST7
Gene summary
Basic gene Info.Gene symbolCST7
Gene namecystatin F (leukocystatin)
SynonymsCMAP
CytomapUCSC genome browser: 20p11.21
Type of geneprotein-coding
RefGenesNM_003650.3,
Descriptioncystatin-7cystatin-Fcystatin-like metastasis-associated proteinleukocystatin
Modification date20141207
dbXrefs MIM : 603253
HGNC : HGNC
Ensembl : ENSG00000077984
HPRD : 04458
Vega : OTTHUMG00000032108
ProteinUniProt: O76096
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CST7
BioGPS: 8530
PathwayNCI Pathway Interaction Database: CST7
KEGG: CST7
REACTOME: CST7
Pathway Commons: CST7
ContextiHOP: CST7
ligand binding site mutation search in PubMed: CST7
UCL Cancer Institute: CST7
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for CST7

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
T64T64MSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CST7
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T64T64M-0.76238311
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CST7 from PDB

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Differential gene expression and gene-gene network for CST7
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CST7 and the right PPI network was created from samples without mutations in the LBS of CST7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CST7
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CST7
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CST7 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
FULBETA-L-FUCOSE2ch9AT64


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Conservation information for LBS of CST7
Multiple alignments for O76096 in multiple species
LBSAA sequence# speciesSpecies


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