mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TRIM5
Gene summary
Basic gene Info.Gene symbolTRIM5
Gene nametripartite motif containing 5
CytomapUCSC genome browser: 11p15
Type of geneprotein-coding
Descriptionring finger protein 88tripartite motif containing 5 transcript variant iotatripartite motif containing 5 transcript variant kappatripartite motif protein TRIM5tripartite motif-containing protein 5
Modification date20141207
dbXrefs MIM : 608487
Ensembl : ENSG00000132256
HPRD : 07004
Vega : OTTHUMG00000066893
ProteinUniProt: Q9C035
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TRIM5
BioGPS: 85363
PathwayNCI Pathway Interaction Database: TRIM5
Pathway Commons: TRIM5
ContextiHOP: TRIM5
ligand binding site mutation search in PubMed: TRIM5
UCL Cancer Institute: TRIM5
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0002218activation of innate immune response21512573
GO:0002221pattern recognition receptor signaling pathway21512573
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling23077300
GO:0045087innate immune response18248090
GO:0046597negative regulation of viral entry into host cell18248090
GO:0070206protein trimerization17156811
GO:0070534protein K63-linked ubiquitination21512573
GO:1902187negative regulation of viral release from host cell18248090

Ligand binding site mutations for TRIM5
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for TRIM5
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TRIM5 from PDB

Differential gene expression and gene-gene network for TRIM5
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TRIM5 and the right PPI network was created from samples without mutations in the LBS of TRIM5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for TRIM5
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0019693HIV Infections46AlteredExpression, Biomarker, GeneticVariation, Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for TRIM5
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TRIM5 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of TRIM5
Multiple alignments for Q9C035 in multiple species
LBSAA sequence# speciesSpecies
C106KLLLFCQEDGK2Homo sapiens, Pan troglodytes
C106KLLLFCQEDSK1Macaca mulatta
C114DGKVICWLCER2Homo sapiens, Pan troglodytes
C114DSKVICWLCER1Macaca mulatta
C117VICWLCERSQE3Homo sapiens, Macaca mulatta, Pan troglodytes
C15KEEVTCPICLE3Homo sapiens, Macaca mulatta, Pan troglodytes
C18VTCPICLELLT3Homo sapiens, Macaca mulatta, Pan troglodytes
C30PLSLDCGHSFC2Homo sapiens, Pan troglodytes
C30PLSLHCGHSFC1Macaca mulatta
C35CGHSFCQACLT2Homo sapiens, Pan troglodytes
C35CGHSFCQACIT1Macaca mulatta
C38SFCQACLTANH2Homo sapiens, Pan troglodytes
C38SFCQACITANH1Macaca mulatta
C55KGESSCPVCRI2Homo sapiens, Pan troglodytes
C55EGERSCPVCRI1Macaca mulatta
C58SSCPVCRISYQ2Homo sapiens, Pan troglodytes
C58RSCPVCRISYQ1Macaca mulatta
C95QKVDHCARHGE2Homo sapiens, Macaca mulatta
C95QKVDHCAHHGE1Pan troglodytes
D109LFCQEDGKVIC2Homo sapiens, Pan troglodytes
D109LFCQEDSKVIC1Macaca mulatta
H123ERSQEHRGHHT3Homo sapiens, Macaca mulatta, Pan troglodytes
H32SLDCGHSFCQA2Homo sapiens, Pan troglodytes
H32SLHCGHSFCQA1Macaca mulatta
H98DHCARHGEKLL2Homo sapiens, Macaca mulatta
H98DHCAHHGEKLL1Pan troglodytes

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