mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CDC14B
Gene summary
Basic gene Info.Gene symbolCDC14B
Gene namecell division cycle 14B
SynonymsCDC14B3|Cdc14B1|Cdc14B2|hCDC14B
CytomapUCSC genome browser: 9q22.3
Type of geneprotein-coding
RefGenesNM_001077181.1,
NM_003671.3,NM_033331.2,NM_033332.1,
DescriptionCDC14 cell division cycle 14 homolog Bdual specificity protein phosphatase CDC14B
Modification date20141207
dbXrefs MIM : 603505
HGNC : HGNC
Ensembl : ENSG00000081377
HPRD : 04615
Vega : OTTHUMG00000020300
ProteinUniProt: O60729
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CDC14B
BioGPS: 8555
PathwayNCI Pathway Interaction Database: CDC14B
KEGG: CDC14B
REACTOME: CDC14B
Pathway Commons: CDC14B
ContextiHOP: CDC14B
ligand binding site mutation search in PubMed: CDC14B
UCL Cancer Institute: CDC14B
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0031572G2 DNA damage checkpoint18662541
GO:0035335peptidyl-tyrosine dephosphorylation9367992


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Ligand binding site mutations for CDC14B

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F85N84IBLCA1
R320T321MUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CDC14B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R320T321M0.15956611
F85N84I-0.23304409
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CDC14B from PDB

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Differential gene expression and gene-gene network for CDC14B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CDC14B and the right PPI network was created from samples without mutations in the LBS of CDC14B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CDC14B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CDC14B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CDC14B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ACE,ALA,SER,PRO)1oheAF85 R320
WO4TUNGSTATE1ohdAR320


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Conservation information for LBS of CDC14B
Multiple alignments for O60729 in multiple species
LBSAA sequence# speciesSpecies


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