mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for AKR7A2
Gene summary
Basic gene Info.Gene symbolAKR7A2
Gene namealdo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
CytomapUCSC genome browser: 1p36.13
Type of geneprotein-coding
DescriptionAFB1 aldehyde reductase 1AFB1-AR 1HEL-S-166mPSSA reductaseaflatoxin B1 aldehyde reductase member 2aflatoxin beta1 aldehyde reductasealdoketoreductase 7epididymis secretory sperm binding protein Li 166mPsuccinic semialdehyde reductase
Modification date20141207
dbXrefs MIM : 603418
HPRD : 04567
ProteinUniProt: O43488
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AKR7A2
BioGPS: 8574
PathwayNCI Pathway Interaction Database: AKR7A2
Pathway Commons: AKR7A2
ContextiHOP: AKR7A2
ligand binding site mutation search in PubMed: AKR7A2
UCL Cancer Institute: AKR7A2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for AKR7A2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for AKR7A2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for AKR7A2 from PDB

Differential gene expression and gene-gene network for AKR7A2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of AKR7A2 and the right PPI network was created from samples without mutations in the LBS of AKR7A2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for AKR7A2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for AKR7A2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of AKR7A2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of AKR7A2
Multiple alignments for O43488 in multiple species
LBSAA sequence# speciesSpecies
A229AYNPLAGGLLT3Homo sapiens, Mus musculus, Rattus norvegicus
D72GHTELDTAFMY1Homo sapiens
D72GHSELDTAFMY1Mus musculus
D72GLNELDTAFMY1Rattus norvegicus
G230YNPLAGGLLTG3Homo sapiens, Mus musculus, Rattus norvegicus
G231NPLAGGLLTGK3Homo sapiens, Mus musculus, Rattus norvegicus
G316DAVILGMSSLE3Homo sapiens, Mus musculus, Rattus norvegicus
G43---VLGTMEMG1Homo sapiens
G43PATVLGTMEMG1Mus musculus
G43PGTVLGTMEMG1Rattus norvegicus
H141DLFYLHAPDHG2Homo sapiens, Rattus norvegicus
H141DLFYLHAPDHS1Mus musculus
I314RGDAVILGMSS2Mus musculus, Rattus norvegicus
I314HGDAVILGMSS1Homo sapiens
K236GLLTGKYKYED2Homo sapiens, Mus musculus
K236GLLTGKYRYED1Rattus norvegicus
L228YAYNPLAGGLL3Homo sapiens, Mus musculus, Rattus norvegicus
M317AVILGMSSLEQ3Homo sapiens, Mus musculus, Rattus norvegicus
M45TVLGTMEMGRR2Mus musculus, Rattus norvegicus
M45-VLGTMEMGRR1Homo sapiens
N172ELGLSNYASWE3Homo sapiens, Mus musculus, Rattus norvegicus
N226RFYAYNPLAGG3Homo sapiens, Mus musculus, Rattus norvegicus
N326EQLEQNLAATE3Homo sapiens, Mus musculus, Rattus norvegicus
P227FYAYNPLAGGL3Homo sapiens, Mus musculus, Rattus norvegicus
Q197LPTVYQGMYNA3Homo sapiens, Mus musculus, Rattus norvegicus
Q322MSSLEQLEQNL3Homo sapiens, Mus musculus, Rattus norvegicus
Q325LEQLEQNLAAT3Homo sapiens, Mus musculus, Rattus norvegicus
R250KQPVGRFFGNS1Homo sapiens
R250KQPVGRFFGNN1Mus musculus
R250KQPEGRFFGNS1Rattus norvegicus
R50MEMGRRMDASA2Mus musculus, Rattus norvegicus
R50MEMGRRMDAPA1Homo sapiens
S171VELGLSNYASW3Homo sapiens, Mus musculus, Rattus norvegicus
S318VILGMSSLEQL3Homo sapiens, Mus musculus, Rattus norvegicus
T234AGGLLTGKYKY2Homo sapiens, Mus musculus
T234AGGLLTGKYRY1Rattus norvegicus
T44--VLGTMEMGR1Homo sapiens
T44ATVLGTMEMGR1Mus musculus
T44GTVLGTMEMGR1Rattus norvegicus
Y225LRFYAYNPLAG3Homo sapiens, Mus musculus, Rattus norvegicus
Y237LLTGKYKYEDK2Homo sapiens, Mus musculus
Y237LLTGKYRYEDK1Rattus norvegicus
Y260SWAETYRNRFW1Homo sapiens
Y260NWAETYRNRFW1Mus musculus
Y260SWSETYRNRFW1Rattus norvegicus
Y77DTAFMYCDGQS2Mus musculus, Rattus norvegicus
Y77DTAFMYSDGQS1Homo sapiens

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