mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for STK16
Gene summary
Basic gene Info.Gene symbolSTK16
Gene nameserine/threonine kinase 16
CytomapUCSC genome browser: 2q35
Type of geneprotein-coding
DescriptionTGF-beta-stimulated factor 1TSF-1hPSKmyristoylated and palmitoylated serine/threonine-protein kinaseprotein kinase PKL12protein kinase expressed in day 12 fetal liverserine/threonine-protein kinase 16tyrosine-protein kinase STK16
Modification date20141207
dbXrefs MIM : 604719
Ensembl : ENSG00000115661
HPRD : 05281
Vega : OTTHUMG00000154520
ProteinUniProt: O75716
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STK16
BioGPS: 8576
PathwayNCI Pathway Interaction Database: STK16
Pathway Commons: STK16
ContextiHOP: STK16
ligand binding site mutation search in PubMed: STK16
UCL Cancer Institute: STK16
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0046777protein autophosphorylation18184589

Ligand binding site mutations for STK16
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for STK16
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for STK16 from PDB

Differential gene expression and gene-gene network for STK16
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of STK16 and the right PPI network was created from samples without mutations in the LBS of STK16. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for STK16
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for STK16
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of STK16 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of STK16
Multiple alignments for O75716 in multiple species
LBSAA sequence# speciesSpecies
A47DGHFYALKRIL3Homo sapiens, Mus musculus, Rattus norvegicus
A47NEKLYALKKIK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A47TPELYALKKII1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E28VQKLGEGGFSY2Mus musculus, Rattus norvegicus
E28IQKLGEGGFSY1Homo sapiens
E28QKLLGEGGFAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E28QRLLGEGGMSF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E87YSL-KERGAKH2Mus musculus, Rattus norvegicus
E87YCL-RERGAKH1Homo sapiens
E87HQLVKEADGSE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E87SQVMQEKDGSK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F100WLLLPFFKRGT2Homo sapiens, Rattus norvegicus
F100YILFPYFAKGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F100YIVLPYYSLGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F100WLLLPFFKKGT1Mus musculus
F101LLLPFFKRGTL2Homo sapiens, Rattus norvegicus
F101ILFPYFAKGSV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F101IVLPYYSLGSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F101LLLPFFKKGTL1Mus musculus
F45LHDGHFYALKR3Homo sapiens, Mus musculus, Rattus norvegicus
F45VSNEKLYALKK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F45IATPELYALKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G104PFFKRGTLWNE2Homo sapiens, Rattus norvegicus
G104PYFAKGSVAQV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G104PYYSLGSLQDS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G104PFFKKGTLWNE1Mus musculus
G27FVQKLGEGGFS2Mus musculus, Rattus norvegicus
G27FIQKLGEGGFS1Homo sapiens
G27IQKLLGEGGFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G27IQRLLGEGGMS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H92ERGAKHEAWLL3Homo sapiens, Mus musculus, Rattus norvegicus
H92EADGSEFVYIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H92EKDGSKTIYIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K102LLPFFKRGTLW2Homo sapiens, Rattus norvegicus
K102LFPYFAKGSVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K102VLPYYSLGSLQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K102LLPFFKKGTLW1Mus musculus
K49HFYALKRILCH3Homo sapiens, Mus musculus, Rattus norvegicus
K49KLYALKKIKCS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K49ELYALKKIICP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L26LFVQKLGEGGF2Mus musculus, Rattus norvegicus
L26LFIQKLGEGGF1Homo sapiens
L26RIQKLLGEGGF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L26RIQRLLGEGGM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L98EAWLLLPFFKR2Homo sapiens, Rattus norvegicus
L98FVYILFPYFAK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L98TIYIVLPYYSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L98EAWLLLPFFKK1Mus musculus
M165GQPVLM-DLGS3Homo sapiens, Mus musculus, Rattus norvegicus
M165SREIVLTDFGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M165GLPVIG-DLGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P99AWLLLPFFKRG2Homo sapiens, Rattus norvegicus
P99VYILFPYFAKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P99IYIVLPYYSLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P99AWLLLPFFKKG1Mus musculus
Q24RYLFVQKLGEG2Mus musculus, Rattus norvegicus
Q24RYLFIQKLGEG1Homo sapiens
Q24RYRIQKLLGEG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q24RYRIQRLLGEG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R103LPFFKRGTLWN2Homo sapiens, Rattus norvegicus
R103FPYFAKGSVAQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R103LPYYSLGSLQD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R103LPFFKKGTLWN1Mus musculus
R59-EQQDQEEAQR2Mus musculus, Rattus norvegicus
R59-EQQDREEAQR1Homo sapiens
R59FGNKGIKKAMK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R59-SVESISNGMR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V34GGFSYVDLVE-3Homo sapiens, Mus musculus, Rattus norvegicus
V34GGFAFVYLVQ-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V34GGMSFVYLVQL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

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