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mutLBSgeneDB |
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| Gene summary for STK16 |
 Gene summary |
| Basic gene Info. | Gene symbol | STK16 |
| Gene name | serine/threonine kinase 16 | |
| Synonyms | KRCT|MPSK|PKL12|TSF1 | |
| Cytomap | UCSC genome browser: 2q35 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003691.2, NM_032768.1,NM_001008910.2,NR_026909.1, | |
| Description | TGF-beta-stimulated factor 1TSF-1hPSKmyristoylated and palmitoylated serine/threonine-protein kinaseprotein kinase PKL12protein kinase expressed in day 12 fetal liverserine/threonine-protein kinase 16tyrosine-protein kinase STK16 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604719 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000115661 | ||
| HPRD : 05281 | ||
| Vega : OTTHUMG00000154520 | ||
| Protein | UniProt: O75716 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_STK16 | |
| BioGPS: 8576 | ||
| Pathway | NCI Pathway Interaction Database: STK16 | |
| KEGG: STK16 | ||
| REACTOME: STK16 | ||
| Pathway Commons: STK16 | ||
| Context | iHOP: STK16 | |
| ligand binding site mutation search in PubMed: STK16 | ||
| UCL Cancer Institute: STK16 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0046777 | protein autophosphorylation | 18184589 |
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| Ligand binding site mutations for STK16 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K49 | R50Q | COAD | 1 | G27 | G27W | LUSC | 1 | K49 | R50Q | LUSC | 1 | K49 | R50Q | UCEC | 1 | M165 | D166E | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for STK16 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | M165 | D166E | -0.90231094 | G27 | G27W | -0.68740047 | K49 | R50Q | -0.52581131 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for STK16 from PDB |
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| Differential gene expression and gene-gene network for STK16 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for STK16 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for STK16 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of STK16 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | STU | STAUROSPORINE | 2buj | B | G27 K49 M165 | STU | STAUROSPORINE | 2buj | A | G27 M165 |
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| Conservation information for LBS of STK16 |
| Multiple alignments for O75716 in multiple species |
| LBS | AA sequence | # species | Species | A47 | DGHFYALKRIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A47 | NEKLYALKKIK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A47 | TPELYALKKII | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E28 | VQKLGEGGFSY | 2 | Mus musculus, Rattus norvegicus | E28 | IQKLGEGGFSY | 1 | Homo sapiens | E28 | QKLLGEGGFAF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E28 | QRLLGEGGMSF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E87 | YSL-KERGAKH | 2 | Mus musculus, Rattus norvegicus | E87 | YCL-RERGAKH | 1 | Homo sapiens | E87 | HQLVKEADGSE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E87 | SQVMQEKDGSK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F100 | WLLLPFFKRGT | 2 | Homo sapiens, Rattus norvegicus | F100 | YILFPYFAKGS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F100 | YIVLPYYSLGS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F100 | WLLLPFFKKGT | 1 | Mus musculus | F101 | LLLPFFKRGTL | 2 | Homo sapiens, Rattus norvegicus | F101 | ILFPYFAKGSV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F101 | IVLPYYSLGSL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F101 | LLLPFFKKGTL | 1 | Mus musculus | F45 | LHDGHFYALKR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F45 | VSNEKLYALKK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F45 | IATPELYALKK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G104 | PFFKRGTLWNE | 2 | Homo sapiens, Rattus norvegicus | G104 | PYFAKGSVAQV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G104 | PYYSLGSLQDS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G104 | PFFKKGTLWNE | 1 | Mus musculus | G27 | FVQKLGEGGFS | 2 | Mus musculus, Rattus norvegicus | G27 | FIQKLGEGGFS | 1 | Homo sapiens | G27 | IQKLLGEGGFA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G27 | IQRLLGEGGMS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H92 | ERGAKHEAWLL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H92 | EADGSEFVYIL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H92 | EKDGSKTIYIV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K102 | LLPFFKRGTLW | 2 | Homo sapiens, Rattus norvegicus | K102 | LFPYFAKGSVA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K102 | VLPYYSLGSLQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K102 | LLPFFKKGTLW | 1 | Mus musculus | K49 | HFYALKRILCH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K49 | KLYALKKIKCS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K49 | ELYALKKIICP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L26 | LFVQKLGEGGF | 2 | Mus musculus, Rattus norvegicus | L26 | LFIQKLGEGGF | 1 | Homo sapiens | L26 | RIQKLLGEGGF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L26 | RIQRLLGEGGM | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L98 | EAWLLLPFFKR | 2 | Homo sapiens, Rattus norvegicus | L98 | FVYILFPYFAK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L98 | TIYIVLPYYSL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L98 | EAWLLLPFFKK | 1 | Mus musculus | M165 | GQPVLM-DLGS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M165 | SREIVLTDFGS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M165 | GLPVIG-DLGS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P99 | AWLLLPFFKRG | 2 | Homo sapiens, Rattus norvegicus | P99 | VYILFPYFAKG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P99 | IYIVLPYYSLG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P99 | AWLLLPFFKKG | 1 | Mus musculus | Q24 | RYLFVQKLGEG | 2 | Mus musculus, Rattus norvegicus | Q24 | RYLFIQKLGEG | 1 | Homo sapiens | Q24 | RYRIQKLLGEG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q24 | RYRIQRLLGEG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R103 | LPFFKRGTLWN | 2 | Homo sapiens, Rattus norvegicus | R103 | FPYFAKGSVAQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R103 | LPYYSLGSLQD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R103 | LPFFKKGTLWN | 1 | Mus musculus | R59 | -EQQDQEEAQR | 2 | Mus musculus, Rattus norvegicus | R59 | -EQQDREEAQR | 1 | Homo sapiens | R59 | FGNKGIKKAMK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R59 | -SVESISNGMR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V34 | GGFSYVDLVE- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V34 | GGFAFVYLVQ- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V34 | GGMSFVYLVQL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) |
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