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mutLBSgeneDB |
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| Gene summary for DYNLL1 |
 Gene summary |
| Basic gene Info. | Gene symbol | DYNLL1 |
| Gene name | dynein, light chain, LC8-type 1 | |
| Synonyms | DLC1|DLC8|DNCL1|DNCLC1|LC8|LC8a|PIN|hdlc1 | |
| Cytomap | UCSC genome browser: 12q24.23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001037494.1, NM_001037495.1,NM_003746.2, | |
| Description | 8 kDa dynein light chaincytoplasmic dynein light polypeptidedynein light chain 1, cytoplasmicdynein, cytoplasmic, light polypeptide 1protein inhibitor of neuronal nitric oxide synthase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601562 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000088986 | ||
| HPRD : 03334 | ||
| Vega : OTTHUMG00000169368 | ||
| Protein | UniProt: P63167 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DYNLL1 | |
| BioGPS: 8655 | ||
| Pathway | NCI Pathway Interaction Database: DYNLL1 | |
| KEGG: DYNLL1 | ||
| REACTOME: DYNLL1 | ||
| Pathway Commons: DYNLL1 | ||
| Context | iHOP: DYNLL1 | |
| ligand binding site mutation search in PubMed: DYNLL1 | ||
| UCL Cancer Institute: DYNLL1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0042326 | negative regulation of phosphorylation | 18579519 |
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| Ligand binding site mutations for DYNLL1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R60 | R60S | BLCA | 1 | E35 | I34V | HNSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DYNLL1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E35 | I34V | -1.2285626 | R60 | R60S | -1.0712741 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DYNLL1 from PDB |
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| Differential gene expression and gene-gene network for DYNLL1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DYNLL1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007786 | Brain Ischemia | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DYNLL1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DYNLL1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | A | E35 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | C | E35 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | E | E35 | III | Peptide ligand (GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | G | E35 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | I | E35 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | K | E35 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR) | 3zkf | A | E35 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR) | 3zkf | C | E35 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR) | 3zkf | E | E35 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR) | 3zkf | G | E35 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR) | 3zkf | I | E35 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR) | 3zkf | K | E35 | III | Peptide ligand (ALA,GLU,MET,LYS,ASP,THR,GLY,ILE,GLN,VAL,ASP,ARG) | 1cmi | A | R60 | III | Peptide ligand (ALA,GLU,MET,LYS,ASP,THR,GLY,ILE,GLN,VAL,ASP,ARG) | 1cmi | B | R60 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | A | R60 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | C | R60 | III | Peptide ligand (GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | E | R60 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | G | R60 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | I | R60 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR,ALA) | 3zke | K | R60 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR) | 3zkf | E | R60 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR) | 3zkf | G | R60 | III | Peptide ligand (VAL,GLY,MET,HIS,SER,LYS,GLY,THR,GLN,THR) | 3zkf | K | R60 |
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| Conservation information for LBS of DYNLL1 |
| Multiple alignments for P63167 in multiple species |
| LBS | AA sequence | # species | Species | A82 | YLGQVAILLFK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E35 | EKYNIEKDIAA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E69 | SYVTHETKHFI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F62 | IVGRNFGSYVT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F73 | HETKHFIYFYL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G63 | VGRNFGSYVTH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G79 | IYFYLGQVAIL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H68 | GSYVTHETKHF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K36 | KYNIEKDIAAH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K43 | IAAHIKKEFDK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N61 | CIVGRNFGSYV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Q80 | YFYLGQVAILL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R60 | HCIVGRNFGSY | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S64 | GRNFGSYVTHE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S88 | ILLFKSG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T67 | FGSYVTHETKH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T70 | YVTHETKHFIY | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V66 | NFGSYVTHETK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y65 | RNFGSYVTHET | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y75 | TKHFIYFYLGQ | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y77 | HFIYFYLGQVA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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