mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CBR1
Gene summary
Basic gene Info.Gene symbolCBR1
Gene namecarbonyl reductase 1
SynonymsCBR|SDR21C1|hCBR1
CytomapUCSC genome browser: 21q22.13
Type of geneprotein-coding
RefGenesNM_001286789.1,
NM_001757.3,
Description15-hydroxyprostaglandin dehydrogenaseNADPH-dependent carbonyl reductase 1carbonyl reductase (NADPH) 1carbonyl reductase [NADPH] 1prostaglandin 9-ketoreductaseprostaglandin-E(2) 9-reductaseshort chain dehydrogenase/reductase family 21C, member 1
Modification date20141207
dbXrefs MIM : 114830
HGNC : HGNC
Ensembl : ENSG00000159228
HPRD : 00267
Vega : OTTHUMG00000086618
ProteinUniProt: P16152
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CBR1
BioGPS: 873
PathwayNCI Pathway Interaction Database: CBR1
KEGG: CBR1
REACTOME: CBR1
Pathway Commons: CBR1
ContextiHOP: CBR1
ligand binding site mutation search in PubMed: CBR1
UCL Cancer Institute: CBR1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0017144drug metabolic process18449627
GO:0042373vitamin K metabolic process18449627
GO:0055114oxidation-reduction process19442656


Top
Ligand binding site mutations for CBR1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S192P190SCOAD1
V138V138IKIRC1
R145V144IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for CBR1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
V138V138I-0.80391311
R145V144I-0.39653301
S192P190S-0.3356639
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CBR1 from PDB

Top
Differential gene expression and gene-gene network for CBR1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CBR1 and the right PPI network was created from samples without mutations in the LBS of CBR1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for CBR1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C2239176Carcinoma, Hepatocellular2Biomarker
umls:C0878544Cardiomyopathies2Biomarker, GeneticVariation
umls:C0009375Colonic Neoplasms2Biomarker
umls:C0033578Prostatic Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for CBR1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB035562-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400Small molecule
ExperimentalDB044633-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)PhenolSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CBR1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


Top
Conservation information for LBS of CBR1
Multiple alignments for P16152 in multiple species
LBSAA sequence# speciesSpecies
A193GWPNSAYGVTK2Mus musculus, Rattus norvegicus
A193GWPSSAYGVTK1Homo sapiens
A193GWPDTAYGVTK1Bos taurus
A236VRTDMAGPKAT3Homo sapiens, Mus musculus, Rattus norvegicus
A236VRTDMGGPKAS1Bos taurus
A91VLVNNAGIAFK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A94NNAGIAFKVAD1Homo sapiens
A94NNAGIAFKTAD1Bos taurus
A94NNAGIAFKVND1Mus musculus
A94NNAGIAFKVVD1Rattus norvegicus
C227LLNACCPGWVR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D63RFHQLDIDNPQ2Mus musculus, Rattus norvegicus
D63RFHQLDIDDLQ1Homo sapiens
D63LFHQLDIDDRQ1Bos taurus
D65HQLDIDNPQSI2Mus musculus, Rattus norvegicus
D65HQLDIDDLQSI1Homo sapiens
D65HQLDIDDRQSI1Bos taurus
E245ATKSPEEGAET3Homo sapiens, Mus musculus, Rattus norvegicus
E245ASKSPEEGAET1Bos taurus
F103ADPTPFHIQAE1Homo sapiens
F103ADTTPFHIQAE1Bos taurus
F103NDDTPFHIQAE1Mus musculus
F103VDPTPFHIQAE1Rattus norvegicus
F95NAGIAFKVADP1Homo sapiens
F95NAGIAFKTADT1Bos taurus
F95NAGIAFKVNDD1Mus musculus
F95NAGIAFKVVDP1Rattus norvegicus
G12VALVTGANKGI3Bos taurus, Mus musculus, Rattus norvegicus
G12VALVTGGNKGI1Homo sapiens
G16TGANKGIGFAI2Mus musculus, Rattus norvegicus
G16TGGNKGIGLAI1Homo sapiens
G16TGANKGIGFVI1Bos taurus
G229NACCPGWVRTD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G92LVNNAGIAFKV3Homo sapiens, Mus musculus, Rattus norvegicus
G92LVNNAGIAFKT1Bos taurus
I141VNVSSIMSVRA1Homo sapiens
I141VNVSSFVSVNS1Bos taurus
I141VNVSSMVSLRA1Mus musculus
I141VNVSSSVSLRA1Rattus norvegicus
I17GGNKGIGLAIV1Homo sapiens
I17GANKGIGFVIV1Bos taurus
I17GANKGIGFAIT1Mus musculus
I17GANKGIGFAIV1Rattus norvegicus
I64FHQLDIDNPQS2Mus musculus, Rattus norvegicus
I64FHQLDIDDLQS1Homo sapiens
I64FHQLDIDDRQS1Bos taurus
I93VNNAGIAFKVA1Homo sapiens
I93VNNAGIAFKTA1Bos taurus
I93VNNAGIAFKVN1Mus musculus
I93VNNAGIAFKVV1Rattus norvegicus
K15VTGANKGIGFA2Mus musculus, Rattus norvegicus
K15VTGGNKGIGLA1Homo sapiens
K15VTGANKGIGFV1Bos taurus
K198AYGVTKIGVTV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K96AGIAFKVADPT1Homo sapiens
K96AGIAFKTADTT1Bos taurus
K96AGIAFKVNDDT1Mus musculus
K96AGIAFKVVDPT1Rattus norvegicus
L28RDLCRLFSGDV1Homo sapiens
L28RDLCRRFSGDV1Bos taurus
L28RDLCRKFSGDV1Mus musculus
L28RDLCRKFLGDV1Rattus norvegicus
L62PRFHQLDIDNP2Mus musculus, Rattus norvegicus
L62PRFHQLDIDDL1Homo sapiens
L62PLFHQLDIDDR1Bos taurus
M142NVSSIMSVRAL1Homo sapiens
M142NVSSFVSVNSL1Bos taurus
M142NVSSMVSLRAL1Mus musculus
M142NVSSSVSLRAL1Rattus norvegicus
M235WVRTDMAGPKA3Homo sapiens, Mus musculus, Rattus norvegicus
M235WVRTDMGGPKA1Bos taurus
N14LVTGANKGIGF3Bos taurus, Mus musculus, Rattus norvegicus
N14LVTGGNKGIGL1Homo sapiens
N90DVLVNNAGIAF3Homo sapiens, Bos taurus, Mus musculus
N90NVLVNNAGIAF1Rattus norvegicus
P228LNACCPGWVRT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q106TPFHIQAEVTM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R145SIMSVRALKSC1Homo sapiens
R145SFVSVNSLKKC1Bos taurus
R145SMVSLRALKNC1Mus musculus
R145SSVSLRALKSC1Rattus norvegicus
R23GLAIVRDLCRL1Homo sapiens
R23GFVIVRDLCRR1Bos taurus
R23GFAITRDLCRK1Mus musculus
R23GFAIVRDLCRK1Rattus norvegicus
R27VRDLCRLFSGD1Homo sapiens
R27VRDLCRRFSGD1Bos taurus
R27TRDLCRKFSGD1Mus musculus
R27VRDLCRKFLGD1Rattus norvegicus
R38VVLTARDVTRG1Homo sapiens
R38VVLTARDEARG1Bos taurus
R38VVLAARDEERG1Mus musculus
R38VVLTARDESRG1Rattus norvegicus
R42ARDVTRGQAAV1Homo sapiens
R42ARDEARGRAAV1Bos taurus
R42ARDEERGQTAV1Mus musculus
R42ARDESRGHEAV1Rattus norvegicus
S139RVVNVSSIMSV1Homo sapiens
S139RVVNVSSFVSV1Bos taurus
S139RVVNVSSMVSL1Mus musculus
S139RVVNVSSSVSL1Rattus norvegicus
S140VVNVSSIMSVR1Homo sapiens
S140VVNVSSFVSVN1Bos taurus
S140VVNVSSMVSLR1Mus musculus
S140VVNVSSSVSLR1Rattus norvegicus
S192EGWPNSAYGVT2Mus musculus, Rattus norvegicus
S192EGWPSSAYGVT1Homo sapiens
S192EGWPDTAYGVT1Bos taurus
T233PGWVRTDMAGP3Homo sapiens, Mus musculus, Rattus norvegicus
T233PGWVRTDMGGP1Bos taurus
V138GRVVNVSSIMS1Homo sapiens
V138GRVVNVSSFVS1Bos taurus
V138GRVVNVSSMVS1Mus musculus
V138GRVVNVSSSVS1Rattus norvegicus
V231CCPGWVRTDMA3Homo sapiens, Mus musculus, Rattus norvegicus
V231CCPGWVRTDMG1Bos taurus
V97GIAFKVADPTP1Homo sapiens
V97GIAFKTADTTP1Bos taurus
V97GIAFKVNDDTP1Mus musculus
V97GIAFKVVDPTP1Rattus norvegicus
W230ACCPGWVRTDM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y194WPNSAYGVTKI2Mus musculus, Rattus norvegicus
Y194WPSSAYGVTKI1Homo sapiens
Y194WPDTAYGVTKI1Bos taurus


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas