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mutLBSgeneDB |
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| Gene summary for RNMT |
 Gene summary |
| Basic gene Info. | Gene symbol | RNMT |
| Gene name | RNA (guanine-7-) methyltransferase | |
| Synonyms | MET|RG7MT1|hCMT1c | |
| Cytomap | UCSC genome browser: 18p11.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003799.1, | |
| Description | hCMT1hMethcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap guanine-N7 methyltransferasemRNA cap methyltransferase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603514 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000101654 | ||
| HPRD : 04622 | ||
| Vega : OTTHUMG00000131718 | ||
| Protein | UniProt: O43148 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RNMT | |
| BioGPS: 8731 | ||
| Pathway | NCI Pathway Interaction Database: RNMT | |
| KEGG: RNMT | ||
| REACTOME: RNMT | ||
| Pathway Commons: RNMT | ||
| Context | iHOP: RNMT | |
| ligand binding site mutation search in PubMed: RNMT | ||
| UCL Cancer Institute: RNMT | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0036265 | RNA (guanine-N7)-methylation | 22099306 |
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| Ligand binding site mutations for RNMT |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G207,G205 | C206Y | COAD | 1 | K180 | S181C | LUAD | 1 | K180 | W178C | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RNMT |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K180 | W178C | -1.375414 | G205 | C206Y | -0.66402598 | G207 | C206Y | -0.66402598 | K180 | S181C | -0.23828595 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RNMT from PDB |
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| Differential gene expression and gene-gene network for RNMT |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RNMT |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RNMT |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RNMT go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of RNMT |
| Multiple alignments for O43148 in multiple species |
| LBS | AA sequence | # species | Species | D227 | KLVCTDIADVS | 2 | Homo sapiens, Xenopus tropicalis | D227 | RLVCADIADIS | 2 | Mus musculus, Rattus norvegicus | D227 | DVVMADVADVS | 1 | Caenorhabditis elegans | D227 | HLICTDIAEVS | 1 | Drosophila melanogaster | D227 | KLVCADIAAVS | 1 | Danio rerio | D261 | EFITADCSKEL | 2 | Mus musculus, Rattus norvegicus | D261 | EFITADSSKEL | 1 | Homo sapiens | D261 | QFIVADCTKEN | 1 | Caenorhabditis elegans | D261 | EFFACDSTLVR | 1 | Drosophila melanogaster | D261 | EFITADCSREL | 1 | Danio rerio | D261 | EFLTADSTKEL | 1 | Xenopus tropicalis | F285 | ICSCQFVCHYS | 1 | Homo sapiens | F285 | LVSCQFALHYS | 1 | Caenorhabditis elegans | F285 | LVSCQFAFHYC | 1 | Drosophila melanogaster | F285 | VCSCQFVYHYS | 1 | Danio rerio | F285 | ICSCQFVYHYS | 1 | Xenopus tropicalis | F285 | VCSCQFACHYS | 1 | Mus musculus | F285 | ICSCQFACHYS | 1 | Rattus norvegicus | G205 | TVLDLGCGKGG | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | G205 | RVLDLACGKGG | 1 | Caenorhabditis elegans | G205 | RVLDMCCGKGG | 1 | Drosophila melanogaster | G205 | AVLDLGCGKGG | 1 | Xenopus tropicalis | G207 | LDLGCGKGGDL | 5 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus | G207 | LDLACGKGGDL | 1 | Caenorhabditis elegans | G207 | LDMCCGKGGDL | 1 | Drosophila melanogaster | I228 | LVCTDIADVSV | 2 | Homo sapiens, Xenopus tropicalis | I228 | LVCADIADISM | 2 | Mus musculus, Rattus norvegicus | I228 | VVMADVADVSI | 1 | Caenorhabditis elegans | I228 | LICTDIAEVSV | 1 | Drosophila melanogaster | I228 | LVCADIAAVSI | 1 | Danio rerio | K180 | FNNWIKSILIG | 2 | Mus musculus, Rattus norvegicus | K180 | FNNWMKSVLIG | 1 | Homo sapiens | K180 | MNNWVKSQLIN | 1 | Caenorhabditis elegans | K180 | FNNWIKSQLIN | 1 | Drosophila melanogaster | K180 | FNNWLKSVLIA | 1 | Danio rerio | K180 | FNNWMKSALIG | 1 | Xenopus tropicalis | M300 | EQADMMLRNAC | 3 | Homo sapiens, Xenopus tropicalis, Rattus norvegicus | M300 | ASARIFLKNAV | 1 | Caenorhabditis elegans | M300 | AQADCMMRNAA | 1 | Drosophila melanogaster | M300 | SQADTMLRNAC | 1 | Danio rerio | M300 | VQADTMLRNAC | 1 | Mus musculus | Q284 | DICSCQFVCHY | 1 | Homo sapiens | Q284 | DLVSCQFALHY | 1 | Caenorhabditis elegans | Q284 | NLVSCQFAFHY | 1 | Drosophila melanogaster | Q284 | DVCSCQFVYHY | 1 | Danio rerio | Q284 | DICSCQFVYHY | 1 | Xenopus tropicalis | Q284 | DVCSCQFACHY | 1 | Mus musculus | Q284 | DICSCQFACHY | 1 | Rattus norvegicus | S262 | FITADCSKELL | 2 | Mus musculus, Rattus norvegicus | S262 | FITADSSKELL | 1 | Homo sapiens | S262 | FIVADCTKENL | 1 | Caenorhabditis elegans | S262 | FFACDSTLVRL | 1 | Drosophila melanogaster | S262 | FITADCSRELL | 1 | Danio rerio | S262 | FLTADSTKELL | 1 | Xenopus tropicalis | V286 | CSCQFVYHYSF | 2 | Danio rerio, Xenopus tropicalis | V286 | CSCQFACHYSF | 2 | Mus musculus, Rattus norvegicus | V286 | CSCQFVCHYSF | 1 | Homo sapiens | V286 | VSCQFALHYSF | 1 | Caenorhabditis elegans | V286 | VSCQFAFHYCF | 1 | Drosophila melanogaster | Y289 | QFVCHYSFESY | 1 | Homo sapiens | Y289 | QFALHYSFVDE | 1 | Caenorhabditis elegans | Y289 | QFAFHYCFESM | 1 | Drosophila melanogaster | Y289 | QFVYHYSFESE | 1 | Danio rerio | Y289 | QFVYHYSFETY | 1 | Xenopus tropicalis | Y289 | QFACHYSFESQ | 1 | Mus musculus | Y289 | QFACHYSFESL | 1 | Rattus norvegicus |
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