mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FBP2
Gene summary
Basic gene Info.Gene symbolFBP2
Gene namefructose-1,6-bisphosphatase 2
Synonyms-
CytomapUCSC genome browser: 9q22.3
Type of geneprotein-coding
RefGenesNM_003837.3,
DescriptionD-fructose-1,6-bisphosphate 1-phosphohydrolase 2FBPase 2fructose-1,6-bisphosphatase isozyme 2hexosediphosphatasemuscle FBPasemuscle fructose-bisphosphatase
Modification date20141207
dbXrefs MIM : 603027
HGNC : HGNC
Ensembl : ENSG00000130957
HPRD : 04322
Vega : OTTHUMG00000020269
ProteinUniProt: O00757
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FBP2
BioGPS: 8789
PathwayNCI Pathway Interaction Database: FBP2
KEGG: FBP2
REACTOME: FBP2
Pathway Commons: FBP2
ContextiHOP: FBP2
ligand binding site mutation search in PubMed: FBP2
UCL Cancer Institute: FBP2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for FBP2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Y245,G247V246ACOAD1
V18R16CCOAD1
G29G29WLUAD1
T178L176FLUSC1
E281E281KSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for FBP2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G29G29W0.69146963
E281E281K-1.4026793
T178L176F-1.3322941
V18R16C-1.309287
Y245V246A-0.8584105
G247V246A-0.8584105
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FBP2 from PDB

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Differential gene expression and gene-gene network for FBP2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FBP2 and the right PPI network was created from samples without mutations in the LBS of FBP2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for FBP2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for FBP2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FBP2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of FBP2
Multiple alignments for O00757 in multiple species
LBSAA sequence# speciesSpecies
A25EKGRQAKGTGE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A25EQSKYPESRGD1Arabidopsis thaliana
A25EQSRNPEARGD1Oryza sativa subsp. japonica
D119YVVCFDPLDGS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D119YCVVFDPLDGS1Arabidopsis thaliana
D119YCVCFDPLDGS1Oryza sativa subsp. japonica
D122CFDPLDGSSNI5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Oryza sativa subsp. japonica
D122VFDPLDGSSNI1Arabidopsis thaliana
D69VNVTGDEVKKL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D69TNIQGEEQKKL1Arabidopsis thaliana
D69TNVQGEEQKKL1Oryza sativa subsp. japonica
E281LRLLYECNPVA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E281LRVLYEVFPMS2Arabidopsis thaliana, Oryza sativa subsp. japonica
E30AKGTGELTQLL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E30PESRGDFTILL1Arabidopsis thaliana
E30PEARGDLTILL1Oryza sativa subsp. japonica
E98CVLVSEENKEA3Mus musculus, Rattus norvegicus, Bos taurus
E98CVLVSEENKDA1Homo sapiens
E98SVLVSEEDEEA1Arabidopsis thaliana
E98CVLVSEEDEEA1Oryza sativa subsp. japonica
G123FDPLDGSSNID6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Arabidopsis thaliana, Oryza sativa subsp. japonica
G22VM-EKGRQAKG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G22VLNEQSKYPES1Arabidopsis thaliana
G22VLNEQSRNPEA1Oryza sativa subsp. japonica
G247GARYVGSMVAD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G247SLRYVGSMVAD1Arabidopsis thaliana
G247SLRYIGSMVAD1Oryza sativa subsp. japonica
G27GRQAKGTGELT4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G27SKYPESRGDFT1Arabidopsis thaliana
G27SRNPEARGDLT1Oryza sativa subsp. japonica
G29QAKGTGELTQL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G29YPESRGDFTIL1Arabidopsis thaliana
G29NPEARGDLTIL1Oryza sativa subsp. japonica
K113KEKRGKYVVCF2Homo sapiens, Bos taurus
K113QERRGKYVVCF1Mus musculus
K113KERRGKYVVCF1Rattus norvegicus
K113PSKRGKYCVVF1Arabidopsis thaliana
K113PALRGKYCVCF1Oryza sativa subsp. japonica
K21YVM-EKGRQAK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K21FVLNEQSKYPE1Arabidopsis thaliana
K21YVLNEQSRNPE1Oryza sativa subsp. japonica
K275KSPKGKLRLLY2Homo sapiens, Bos taurus
K275KSPNGKLRLLY2Mus musculus, Rattus norvegicus
K275KSPNGKLRVLY2Arabidopsis thaliana, Oryza sativa subsp. japonica
L121VCFDPLDGSSN5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Oryza sativa subsp. japonica
L121VVFDPLDGSSN1Arabidopsis thaliana
L31KGTGELTQLLN4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L31ESRGDFTILLS1Arabidopsis thaliana
L31EARGDLTILLS1Oryza sativa subsp. japonica
M249RYVGSMVADVH5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Arabidopsis thaliana
M249RYIGSMVADVH1Oryza sativa subsp. japonica
N213KIYSLNEGYAK2Homo sapiens, Bos taurus
N213KIFSLNEGYAK2Mus musculus, Rattus norvegicus
N213NIYSVNEGNAQ1Arabidopsis thaliana
N213KIYSVNEGNAK1Oryza sativa subsp. japonica
N65IAGSVNVTGDE3Homo sapiens, Rattus norvegicus, Bos taurus
N65ISGSVNVTGDE1Mus musculus
N65LAGETNIQGEE1Arabidopsis thaliana
N65LAGETNVQGEE1Oryza sativa subsp. japonica
R277PKGKLRLLYEC2Homo sapiens, Bos taurus
R277PNGKLRLLYEC2Mus musculus, Rattus norvegicus
R277PNGKLRVLYEV2Arabidopsis thaliana, Oryza sativa subsp. japonica
S124DPLDGSSNIDC6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Arabidopsis thaliana, Oryza sativa subsp. japonica
S248ARYVGSMVADV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S248LRYVGSMVADV1Arabidopsis thaliana
S248LRYIGSMVADV1Oryza sativa subsp. japonica
T178LVALSTGQGVD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T178MLVLSTGTGVH1Arabidopsis thaliana
T178TLVLSTGNGVN1Oryza sativa subsp. japonica
T28RQAKGTGELTQ4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T28KYPESRGDFTI1Arabidopsis thaliana
T28RNPEARGDLTI1Oryza sativa subsp. japonica
T32GTGELTQLLNS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T32SRGDFTILLSH1Arabidopsis thaliana
T32ARGDLTILLSH1Oryza sativa subsp. japonica
V161PGRNIVAAGYA3Mus musculus, Rattus norvegicus, Bos taurus
V161CGRNIVAAGYA1Homo sapiens
V161PGNEMVAAGYC1Arabidopsis thaliana
V161PGKNMVAAGYC1Oryza sativa subsp. japonica
V18TLTRYVM-EKG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V18TITRFVLNEQS1Arabidopsis thaliana
V18TITRYVLNEQS1Oryza sativa subsp. japonica
Y114EKRGKYVVCFD2Homo sapiens, Bos taurus
Y114ERRGKYVVCFD2Mus musculus, Rattus norvegicus
Y114SKRGKYCVVFD1Arabidopsis thaliana
Y114ALRGKYCVCFD1Oryza sativa subsp. japonica
Y216SLNEGYAKYFD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y216SVNEGNAQNWD1Arabidopsis thaliana
Y216SVNEGNAKNWD1Oryza sativa subsp. japonica
Y245PYGARYVGSMV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y245AKSLRYVGSMV1Arabidopsis thaliana
Y245PKSLRYIGSMV1Oryza sativa subsp. japonica
Y265GGIFLYPANQK2Homo sapiens, Bos taurus
Y265GGIFMYPANQK2Mus musculus, Rattus norvegicus
Y265GGIFLYPADKK1Arabidopsis thaliana
Y265GGVFLYPADKK1Oryza sativa subsp. japonica


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