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mutLBSgeneDB |
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| Gene summary for TNFRSF10B |
 Gene summary |
| Basic gene Info. | Gene symbol | TNFRSF10B |
| Gene name | tumor necrosis factor receptor superfamily, member 10b | |
| Synonyms | CD262|DR5|KILLER|KILLER/DR5|TRAIL-R2|TRAILR2|TRICK2|TRICK2A|TRICK2B|TRICKB|ZTNFR9 | |
| Cytomap | UCSC genome browser: 8p22-p21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003842.4, NM_147187.2,NR_027140.1, | |
| Description | Fas-like proteinTNF receptor superfamily member 10bTNF-related apoptosis-inducing ligand receptor 2apoptosis inducing protein TRICK2A/2Bapoptosis inducing receptor TRAIL-R2cytotoxic TRAIL receptor-2death domain containing receptor for TRAIL/Apo-2Ld | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 603612 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000120889 | ||
| HPRD : 04680 | ||
| Vega : OTTHUMG00000097826 | ||
| Protein | UniProt: O14763 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TNFRSF10B | |
| BioGPS: 8795 | ||
| Pathway | NCI Pathway Interaction Database: TNFRSF10B | |
| KEGG: TNFRSF10B | ||
| REACTOME: TNFRSF10B | ||
| Pathway Commons: TNFRSF10B | ||
| Context | iHOP: TNFRSF10B | |
| ligand binding site mutation search in PubMed: TNFRSF10B | ||
| UCL Cancer Institute: TNFRSF10B | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0034976 | response to endoplasmic reticulum stress | 15322075 |
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| Ligand binding site mutations for TNFRSF10B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R115 | R115H | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TNFRSF10B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R115 | R115H | -1.2469208 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TNFRSF10B from PDB |
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| Differential gene expression and gene-gene network for TNFRSF10B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TNFRSF10B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1168401 | Carcinoma, squamous cell of head and neck | 3 | Biomarker, GeneticVariation |
| umls:C0023904 | Liver Neoplasms, Experimental | 1 | Therapeutic |
| umls:C0030297 | Pancreatic Neoplasms | 1 | Therapeutic |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TNFRSF10B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Investigational | DB05895 | HGS-TR2J | Biotech |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TNFRSF10B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 4i9x | D | R115 |
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| Conservation information for LBS of TNFRSF10B |
| Multiple alignments for O14763 in multiple species |
| LBS | AA sequence | # species | Species |
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