mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CDKL1
Gene summary
Basic gene Info.Gene symbolCDKL1
Gene namecyclin-dependent kinase-like 1 (CDC2-related kinase)
CytomapUCSC genome browser: 14q21.3
Type of geneprotein-coding
DescriptionCDC2-related kinase 1cyclin-dependent kinase-like 1protein kinase p42 KKIALREserine/threonine protein kinase KKIALREserine/threonine-protein kinase KKIALRE
Modification date20141207
dbXrefs MIM : 603441
Ensembl : ENSG00000100490
HPRD : 10348
Vega : OTTHUMG00000140290
ProteinUniProt: Q00532
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CDKL1
BioGPS: 8814
PathwayNCI Pathway Interaction Database: CDKL1
Pathway Commons: CDKL1
ContextiHOP: CDKL1
ligand binding site mutation search in PubMed: CDKL1
UCL Cancer Institute: CDKL1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for CDKL1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CDKL1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CDKL1 from PDB

Differential gene expression and gene-gene network for CDKL1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CDKL1 and the right PPI network was created from samples without mutations in the LBS of CDKL1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CDKL1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CDKL1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CDKL1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of CDKL1
Multiple alignments for Q00532 in multiple species
LBSAA sequence# speciesSpecies
A31TGQIVAIKRFL2Mus musculus, Rattus norvegicus
A31TGQIVAIKKFL1Homo sapiens
A31TGQIVAIKKFV1Danio rerio
C83LVFEYCDHTVL3Homo sapiens, Danio rerio, Mus musculus
C83LVFEYCHHTVL1Rattus norvegicus
D144VIKLCDFGFAR3Homo sapiens, Danio rerio, Rattus norvegicus
D144AIKLCDFGFAR1Mus musculus
D84VFEYCDHTVLH2Homo sapiens, Mus musculus
D84VFEYCDHTVLN1Danio rerio
D84VFEYCHHTVLH1Rattus norvegicus
E12IGKIGEGSYGV3Homo sapiens, Mus musculus, Rattus norvegicus
E12ISKIGEGSYGV1Danio rerio
E81LHLVFEYCDHT3Homo sapiens, Danio rerio, Mus musculus
E81LHLVFEYCHHT1Rattus norvegicus
F80RLHLVFEYCDH2Homo sapiens, Mus musculus
F80KLHLVFEYCDH1Danio rerio
F80RLHLVFEYCHH1Rattus norvegicus
G11KIGKIGEGSYG3Homo sapiens, Mus musculus, Rattus norvegicus
G11KISKIGEGSYG1Danio rerio
G13GKIGEGSYGVV3Homo sapiens, Mus musculus, Rattus norvegicus
G13SKIGEGSYGVV1Danio rerio
G16GEGSYGVVFKC4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
H89DHTVLHELDRY2Homo sapiens, Mus musculus
H89DHTVLNELDRY1Danio rerio
H89HHTVLHELDRY1Rattus norvegicus
I10EKIGKIGEGSY3Homo sapiens, Mus musculus, Rattus norvegicus
I10EKISKIGEGSY1Danio rerio
K33QIVAIKRFLET2Mus musculus, Rattus norvegicus
K33QIVAIKKFLES1Homo sapiens
K33QIVAIKKFVES1Danio rerio
L133KPENILITKHS2Homo sapiens, Rattus norvegicus
L133KPENILITKHQ1Danio rerio
L133KPENILITKQS1Mus musculus
N131DVKPENILITK4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
T86EYCDHTVLHEL2Homo sapiens, Mus musculus
T86EYCDHTVLNEL1Danio rerio
T86EYCHHTVLHEL1Rattus norvegicus
V18GSYGVVFKCRN4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
Y15IGEGSYGVVFK4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
Y82HLVFEYCDHTV3Homo sapiens, Danio rerio, Mus musculus
Y82HLVFEYCHHTV1Rattus norvegicus

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