mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for KAT2B

Gene summary

Basic gene Info.	Gene symbol	KAT2B
	Gene name	K(lysine) acetyltransferase 2B
	Synonyms	CAF\|P/CAF\|PCAF
	Cytomap	UCSC genome browser: 3p24
	Type of gene	protein-coding
	RefGenes	NM_003884.4,
	Description	CREBBP-associated factorhistone acetylase PCAFhistone acetyltransferase KAT2Bhistone acetyltransferase PCAFlysine acetyltransferase 2Bp300/CBP-associated factor
	Modification date	20141207
dbXrefs	MIM : 602303
	HGNC : HGNC
	Ensembl : ENSG00000114166
	HPRD : 06780
	Vega : OTTHUMG00000130481
Protein	UniProt: Q92831 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_KAT2B
	BioGPS: 8850
Pathway	NCI Pathway Interaction Database: KAT2B
	KEGG: KAT2B
	REACTOME: KAT2B
	Pathway Commons: KAT2B
Context	iHOP: KAT2B
	ligand binding site mutation search in PubMed: KAT2B
	UCL Cancer Institute: KAT2B
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0006338	chromatin remodeling	17707232
GO:0008285	negative regulation of cell proliferation	8684459
GO:0010835	regulation of protein ADP-ribosylation	19470756
GO:0018076	N-terminal peptidyl-lysine acetylation	12435739
GO:0018393	internal peptidyl-lysine acetylation	23932781
GO:0018394	peptidyl-lysine acetylation	19303849
GO:0032869	cellular response to insulin stimulus	19303849
GO:0043966	histone H3 acetylation	18838386
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	19470756

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Ligand binding site mutations for KAT2B

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
K753	R754I	COAD	1
G586	G586V	LUSC	1
Y612	E611K	SKCM	1
V763	V763A	STAD	1
V795	R794Q	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for KAT2B

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
G586	G586V	0.34385872
V795	R794Q	-1.4829277
V763	V763A	-1.4466921
Y612	E611K	-1.2497196
K753	R754I	-0.15795256

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KAT2B from PDB

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Differential gene expression and gene-gene network for KAT2B

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of KAT2B and the right PPI network was created from samples without mutations in the LBS of KAT2B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for KAT2B

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for KAT2B

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Nutraceutical	DB01992	Coenzyme A	Small molecule
Experimental	DB08186	(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE	Small molecule
Experimental	DB08291	N-(3-AMINOPROPYL)-2-NITROBENZENAMINE	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KAT2B go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
COA		COENZYME A	1cm0	B	G586
COA		COENZYME A	4nsq	D	G586
COA		COENZYME A	1cm0	A	G586 Y612
COA		COENZYME A	4nsq	A	G586 Y612
COA		COENZYME A	4nsq	B	G586 Y612
COA		COENZYME A	4nsq	C	G586 Y612
III		Peptide ligand (SER,TYR,GLY,ARG,LYS,LYS,ARG,ARG,GLN,ARG,CYS)	1jm4	B	K753
III		Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA)	2rnw	A	K753
5WU		1-(2-HYDROXYETHYL)-3-METHYL-6,7-DIHYDRO-5~{H}-INDAZOL- 4-ONE	5fe7	A	K753
5WS		~{N}-(1,4-DIMETHYL-2-OXIDANYLIDENE-QUINOLIN-7-YL) METHANESULFONAMIDE	5fe9	A	K753
5WS		~{N}-(1,4-DIMETHYL-2-OXIDANYLIDENE-QUINOLIN-7-YL) METHANESULFONAMIDE	5fe9	B	K753
MIB		(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE	1zs5	A	K753 V795
III		Peptide ligand (SER,THR,GLY,GLY,VAL,LYS,LYS,PRO,HIS,ARG,TYR,LYS,CYS)	2rnx	A	V763

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Conservation information for LBS of KAT2B

Multiple alignments for Q92831 in multiple species

LBS	AA sequence	# species	Species
A575	EIVFCAISSTE	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A575	EIVFCAVTSNE	2	Homo sapiens, Mus musculus
A575	EIVFCAIASNE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A613	YADNYAIGYFK	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 12
A613	YADEYAIGYFK	2	Homo sapiens, Mus musculus
A757	VKRTEAPGYYE	2	Homo sapiens, Mus musculus
A757	VSKEDVPDYYE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A757	VNRDEVPDYYE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A757	VNKEEVPDYYD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A757	VNKEEVPDYYE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C574	AEIVFCAISST	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C574	TEIVFCAVTSN	2	Homo sapiens, Mus musculus
C574	AEIVFCAIASN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C799	RVFTNCKEYNP	2	Homo sapiens, Mus musculus
C799	LIFNNCRAYNG	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C799	YIFDNCRSYND	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C799	LVFNNCRMYNG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D769	IRFPMDLKTMS	2	Homo sapiens, Mus musculus
D769	IKEPMDLSTME	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D769	IEHPMDLSTME	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D769	IKEPMDLSSME	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E750	AWPFMEPVKRT	2	Homo sapiens, Mus musculus
E750	AWPFLQPVNKE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E750	SWPFMQPVSKE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E750	AWPFLQPVNRD	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E756	PVKRTEAPGYY	2	Homo sapiens, Mus musculus
E756	PVNKEEVPDYY	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E756	PVSKEDVPDYY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E756	PVNRDEVPDYY	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E762	APGYYEVIRFP	2	Homo sapiens, Mus musculus
E762	VPDYYEFIKEP	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E762	VPDYYEVIEHP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E762	VPDYYDFIKEP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E801	FTNCKEYNPPE	2	Homo sapiens, Mus musculus
E801	FNNCRAYNGEN	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E801	FDNCRSYNDSN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E801	FNNCRMYNGEN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E806	EYNPPESEYYK	2	Homo sapiens, Mus musculus
E806	AYNGENTSYFK	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E806	SYNDSNTTYYK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E806	MYNGENTSYYK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E808	NPPESEYYKCA	2	Homo sapiens, Mus musculus
E808	NGENTSYFKYA	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E808	NDSNTTYYKNA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E808	NGENTSYYKYA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F617	YAIGYFKKQGF	6	Homo sapiens, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CB
F748	AAAWPFLQPVN	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F748	QSAWPFMEPVK	1	Homo sapiens
F748	PNAWPFMEPVK	1	Mus musculus
F748	PSSWPFMQPVS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G584	TEQVRGYGAHL	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G584	NEQVKGYGTHL	2	Homo sapiens, Mus musculus
G584	NEQVRGYGSHL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G586	QVRGYGAHLMN	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G586	QVKGYGTHLMN	2	Homo sapiens, Mus musculus
G586	QVRGYGSHLMN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G615	DNYAIGYFKKQ	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 12
G615	DEYAIGYFKKQ	2	Homo sapiens, Mus musculus
G759	RTEAPGYYEVI	2	Homo sapiens, Mus musculus
G759	KEDVPDYYEVI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G759	RDEVPDYYEFI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G759	KEEVPDYYDFI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G759	KEEVPDYYEFI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K583	STEQVRGYGAH	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K583	SNEQVKGYGTH	2	Homo sapiens, Mus musculus
K583	SNEQVRGYGSH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K619	IGYFKKQGFTK	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 12
K619	IGYFKKQGFSK	2	Homo sapiens, Mus musculus
K753	FMEPVKRTEAP	2	Homo sapiens, Mus musculus
K753	FLQPVNKEEVP	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K753	FMQPVSKEDVP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K753	FLQPVNRDEVP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L526	IFQKQLPKMPK	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L526	VFSHQLPRMPK	2	Homo sapiens, Mus musculus
L526	IFMKQLPKMPK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M768	VIRFPMDLKTM	2	Homo sapiens, Mus musculus
M768	FIKEPMDLSTM	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M768	VIEHPMDLSTM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M768	FIKEPMDLSSM	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N798	QRVFTNCKEYN	2	Homo sapiens, Mus musculus
N798	RLIFNNCRAYN	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N798	KYIFDNCRSYN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N798	RLVFNNCRMYN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N803	NCKEYNPPESE	2	Homo sapiens, Mus musculus
N803	NCRAYNGENTS	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N803	NCRSYNDSNTT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N803	NCRMYNGENTS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P747	HAAAWPFLQPV	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P747	HQSAWPFMEPV	1	Homo sapiens
P747	HPNAWPFMEPV	1	Mus musculus
P747	HPSSWPFMQPV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P751	WPFMEPVKRTE	2	Homo sapiens, Mus musculus
P751	WPFLQPVNKEE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P751	WPFMQPVSKED	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P751	WPFLQPVNRDE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P758	KRTEAPGYYEV	2	Homo sapiens, Mus musculus
P758	SKEDVPDYYEV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P758	NRDEVPDYYEF	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P758	NKEEVPDYYDF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P758	NKEEVPDYYEF	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P804	CKEYNPPESEY	2	Homo sapiens, Mus musculus
P804	CRAYNGENTSY	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P804	CRSYNDSNTTY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P804	CRMYNGENTSY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q525	NIFQKQLPKMP	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q525	NVFSHQLPRMP	2	Homo sapiens, Mus musculus
Q525	NIFMKQLPKMP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q581	ISSTEQVRGYG	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q581	VTSNEQVKGYG	2	Homo sapiens, Mus musculus
Q581	IASNEQVRGYG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S807	YNPPESEYYKC	2	Homo sapiens, Mus musculus
S807	YNGENTSYFKY	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S807	YNDSNTTYYKN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S807	YNGENTSYYKY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T587	VRGYGAHLMNH	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T587	VKGYGTHLMNH	2	Homo sapiens, Mus musculus
T587	VRGYGSHLMNH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V576	IVFCAISSTEQ	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V576	IVFCAVTSNEQ	2	Homo sapiens, Mus musculus
V576	IVFCAIASNEQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V582	SSTEQVRGYGA	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V582	TSNEQVKGYGT	2	Homo sapiens, Mus musculus
V582	ASNEQVRGYGS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V752	PFMEPVKRTEA	2	Homo sapiens, Mus musculus
V752	PFLQPVNKEEV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V752	PFMQPVSKEDV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V752	PFLQPVNRDEV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V763	PGYYEVIRFPM	2	Homo sapiens, Mus musculus
V763	PDYYEFIKEPM	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V763	PDYYEVIEHPM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V763	PDYYDFIKEPM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V795	ADLQRVFTNCK	2	Homo sapiens, Mus musculus
V795	YDARLIFNNCR	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V795	RDAKYIFDNCR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V795	YDARLVFNNCR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W746	NHAAAWPFLQP	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
W746	SHQSAWPFMEP	1	Homo sapiens
W746	NHPNAWPFMEP	1	Mus musculus
W746	NHPSSWPFMQP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y585	EQVRGYGAHLM	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y585	EQVKGYGTHLM	2	Homo sapiens, Mus musculus
Y585	EQVRGYGSHLM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y612	TYADNYAIGYF	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 12
Y612	TYADEYAIGYF	2	Homo sapiens, Mus musculus
Y616	NYAIGYFKKQG	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 12
Y616	EYAIGYFKKQG	2	Homo sapiens, Mus musculus
Y760	TEAPGYYEVIR	2	Homo sapiens, Mus musculus
Y760	EDVPDYYEVIE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y760	DEVPDYYEFIK	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y760	EEVPDYYDFIK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y760	EEVPDYYEFIK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y802	TNCKEYNPPES	2	Homo sapiens, Mus musculus
Y802	NNCRAYNGENT	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y802	DNCRSYNDSNT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y802	NNCRMYNGENT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y809	GENTSYFKYAN	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y809	PPESEYYKCAN	1	Homo sapiens
Y809	PPESEYYKCAS	1	Mus musculus
Y809	DSNTTYYKNAD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y809	GENTSYYKYAN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)