mutLBSgeneDB |
Gene summary for ARHGEF7 |
![]() |
Basic gene Info. | Gene symbol | ARHGEF7 |
Gene name | Rho guanine nucleotide exchange factor (GEF) 7 | |
Synonyms | BETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB | |
Cytomap | UCSC genome browser: 13q34 | |
Type of gene | protein-coding | |
RefGenes | NM_001113511.1, NM_001113512.1,NM_001113513.1,NM_003899.3,NM_145735.2, | |
Description | PAK-interacting exchange factor betaSH3 domain-containing proline-rich proteinguanine nucleotide exchange factor 7rho guanine nucleotide exchange factor 7 | |
Modification date | 20141222 | |
dbXrefs | MIM : 605477 | |
HGNC : HGNC | ||
Ensembl : ENSG00000102606 | ||
HPRD : 05688 | ||
Vega : OTTHUMG00000017357 | ||
Protein | UniProt: Q14155 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ARHGEF7 | |
BioGPS: 8874 | ||
Pathway | NCI Pathway Interaction Database: ARHGEF7 | |
KEGG: ARHGEF7 | ||
REACTOME: ARHGEF7 | ||
Pathway Commons: ARHGEF7 | ||
Context | iHOP: ARHGEF7 | |
ligand binding site mutation search in PubMed: ARHGEF7 | ||
UCL Cancer Institute: ARHGEF7 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID | GO:0010763 | positive regulation of fibroblast migration | 21423176 | GO:0043547 | positive regulation of GTPase activity | 21048939 | GO:0048041 | focal adhesion assembly | 21423176 |
Top |
Ligand binding site mutations for ARHGEF7 |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | G220 | I218T | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for ARHGEF7 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for ARHGEF7 |
![]() |
![]() |
Top |
Top |
Phenotype information for ARHGEF7 |
![]() |
Disease ID | Disease name | # PubMed | Association type |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for ARHGEF7 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of ARHGEF7 |
![]() |
LBS | AA sequence | # species | Species |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |