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mutLBSgeneDB |
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| Gene summary for SGPL1 |
 Gene summary |
| Basic gene Info. | Gene symbol | SGPL1 |
| Gene name | sphingosine-1-phosphate lyase 1 | |
| Synonyms | S1PL|SPL | |
| Cytomap | UCSC genome browser: 10q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003901.3, | |
| Description | SP-lyase 1SPL 1hSPLsphingosine-1-phosphate aldolase | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 603729 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000166224 | ||
| HPRD : 07224 | ||
| Vega : OTTHUMG00000018421 | ||
| Protein | UniProt: O95470 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SGPL1 | |
| BioGPS: 8879 | ||
| Pathway | NCI Pathway Interaction Database: SGPL1 | |
| KEGG: SGPL1 | ||
| REACTOME: SGPL1 | ||
| Pathway Commons: SGPL1 | ||
| Context | iHOP: SGPL1 | |
| ligand binding site mutation search in PubMed: SGPL1 | ||
| UCL Cancer Institute: SGPL1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006631 | fatty acid metabolic process | 24809814 | GO:0006672 | ceramide metabolic process | 14570870 | GO:0030149 | sphingolipid catabolic process | 24809814 | GO:0097190 | apoptotic signaling pathway | 14570870 |
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| Ligand binding site mutations for SGPL1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | M528 | G527D | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SGPL1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | M528 | G527D | -0.68177487 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SGPL1 from PDB |
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| Differential gene expression and gene-gene network for SGPL1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SGPL1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SGPL1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Nutraceutical | DB00114 | Pyridoxal Phosphate | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SGPL1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 30J | 6-[(2R)-4-(4-BENZYL-7-CHLOROPHTHALAZIN-1-YL)-2- METHYLPIPERAZIN-1-YL]PYRIDINE-3-CARBONITRILE | 4q6r | B | M528 |
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| Conservation information for LBS of SGPL1 |
| Multiple alignments for O95470 in multiple species |
| LBS | AA sequence | # species | Species | A388 | QGGIYASPTIA | 1 | Homo sapiens | A388 | TGGLYGSPTLA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A388 | SGGLYVSPTIA | 1 | Arabidopsis thaliana | A388 | TGGLYVSPTIA | 1 | Oryza sativa subsp. japonica | A388 | PGGVYGSPTVN | 1 | Drosophila melanogaster | A388 | QGGVYASPSIA | 1 | Mus musculus | A388 | QGGIYASPSIA | 1 | Rattus norvegicus | D176 | NPLHPDIFPGL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D176 | NQLHPDVFPAV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D176 | NPLHIDVFQSV | 1 | Arabidopsis thaliana | D176 | NPLHQDVFKSV | 1 | Oryza sativa subsp. japonica | D176 | NPLHADLFPGV | 1 | Drosophila melanogaster | F545 | ELSSVFLDSLY | 1 | Homo sapiens | F545 | KLIVGFLDALY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F545 | ELLVSFMDSQY | 1 | Arabidopsis thaliana | F545 | ELLVEFMDASC | 1 | Oryza sativa subsp. japonica | F545 | EVTRLFLHSMY | 1 | Drosophila melanogaster | F545 | EISSVFLDCLY | 1 | Mus musculus | F545 | EISSVFLDSLY | 1 | Rattus norvegicus | H174 | WSNPLHPDIFP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H174 | VANQLHPDVFP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H174 | HTNPLHIDVFQ | 1 | Arabidopsis thaliana | H174 | HTNPLHQDVFK | 1 | Oryza sativa subsp. japonica | H174 | YTNPLHADLFP | 1 | Drosophila melanogaster | I386 | DWQGGIYASPT | 1 | Homo sapiens | I386 | AWTGGLYGSPT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I386 | EWSGGLYVSPT | 1 | Arabidopsis thaliana | I386 | EWTGGLYVSPT | 1 | Oryza sativa subsp. japonica | I386 | DWPGGVYGSPT | 1 | Drosophila melanogaster | I386 | DWQGGVYASPS | 1 | Mus musculus | I386 | DWQGGIYASPS | 1 | Rattus norvegicus | I525 | TGMGAIYGMAQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I525 | DGTSALYGVAG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I525 | GGLAPIYGAAG | 1 | Arabidopsis thaliana | I525 | GGRAPIYGAAG | 1 | Oryza sativa subsp. japonica | I525 | VGKMALYGMAQ | 1 | Drosophila melanogaster | K353 | SADTHKYGYAP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K353 | SCDTHKYGFAP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K353 | SVDVHKYGLAP | 1 | Arabidopsis thaliana | K353 | STDVHKYGLAP | 1 | Oryza sativa subsp. japonica | K353 | SADTHKYGFAP | 1 | Drosophila melanogaster | L173 | TWSNPLHPDIF | 2 | Mus musculus, Rattus norvegicus | L173 | AWSNPLHPDIF | 1 | Homo sapiens | L173 | CVANQLHPDVF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L173 | AHTNPLHIDVF | 1 | Arabidopsis thaliana | L173 | SHTNPLHQDVF | 1 | Oryza sativa subsp. japonica | L173 | SYTNPLHADLF | 1 | Drosophila melanogaster | L541 | NMVAELSSVFL | 1 | Homo sapiens | L541 | GVADKLIVGFL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L541 | GMVNELLVSFM | 1 | Arabidopsis thaliana | L541 | GMVRELLVEFM | 1 | Oryza sativa subsp. japonica | L541 | SVIGEVTRLFL | 1 | Drosophila melanogaster | L541 | KLVAEISSVFL | 1 | Mus musculus | L541 | KMVAEISSVFL | 1 | Rattus norvegicus | M528 | APIYGAAGKMP | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | M528 | GAIYGMAQATI | 2 | Mus musculus, Rattus norvegicus | M528 | GAIYGMAQTTV | 1 | Homo sapiens | M528 | SALYGVAGSVK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M528 | MALYGMAQSIP | 1 | Drosophila melanogaster | N171 | EFTWSNPLHPD | 2 | Mus musculus, Rattus norvegicus | N171 | DFAWSNPLHPD | 1 | Homo sapiens | N171 | KYCVANQLHPD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N171 | MFAHTNPLHID | 1 | Arabidopsis thaliana | N171 | MFSHTNPLHQD | 1 | Oryza sativa subsp. japonica | N171 | KASYTNPLHAD | 1 | Drosophila melanogaster | P175 | SNPLHPDIFPG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P175 | ANQLHPDVFPA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P175 | TNPLHIDVFQS | 1 | Arabidopsis thaliana | P175 | TNPLHQDVFKS | 1 | Oryza sativa subsp. japonica | P175 | TNPLHADLFPG | 1 | Drosophila melanogaster | S542 | MVAELSSVFLD | 1 | Homo sapiens | S542 | VADKLIVGFLD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S542 | MVNELLVSFMD | 1 | Arabidopsis thaliana | S542 | MVRELLVEFMD | 1 | Oryza sativa subsp. japonica | S542 | VIGEVTRLFLH | 1 | Drosophila melanogaster | S542 | LVAEISSVFLD | 1 | Mus musculus | S542 | MVAEISSVFLD | 1 | Rattus norvegicus | T148 | GRASGTVYSGE | 1 | Homo sapiens | T148 | GKVSGAVYHGG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T148 | GKCSGTVYIGG | 1 | Arabidopsis thaliana | T148 | GKCSGTVYIAG | 1 | Oryza sativa subsp. japonica | T148 | GRVSGAVYGYK | 1 | Drosophila melanogaster | T148 | GKASGAVYNGE | 1 | Mus musculus | T148 | GKASGAVYSGE | 1 | Rattus norvegicus | V538 | VDRNMVAELSS | 1 | Homo sapiens | V538 | KTAGVADKLIV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V538 | PDRGMVNELLV | 1 | Arabidopsis thaliana | V538 | PDRGMVRELLV | 1 | Oryza sativa subsp. japonica | V538 | PDRSVIGEVTR | 1 | Drosophila melanogaster | V538 | IDRKLVAEISS | 1 | Mus musculus | V538 | IDRKMVAEISS | 1 | Rattus norvegicus | Y150 | ASGTVYSGEEK | 1 | Homo sapiens | Y150 | VSGAVYHGGDD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y150 | CSGTVYIGGAE | 1 | Arabidopsis thaliana | Y150 | CSGTVYIAGSE | 1 | Oryza sativa subsp. japonica | Y150 | VSGAVYGYKPD | 1 | Drosophila melanogaster | Y150 | ASGAVYNGEPK | 1 | Mus musculus | Y150 | ASGAVYSGEPK | 1 | Rattus norvegicus | Y387 | WQGGIYASPTI | 1 | Homo sapiens | Y387 | WTGGLYGSPTL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y387 | WSGGLYVSPTI | 1 | Arabidopsis thaliana | Y387 | WTGGLYVSPTI | 1 | Oryza sativa subsp. japonica | Y387 | WPGGVYGSPTV | 1 | Drosophila melanogaster | Y387 | WQGGVYASPSI | 1 | Mus musculus | Y387 | WQGGIYASPSI | 1 | Rattus norvegicus |
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