mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SGPL1
Gene summary
Basic gene Info.Gene symbolSGPL1
Gene namesphingosine-1-phosphate lyase 1
CytomapUCSC genome browser: 10q21
Type of geneprotein-coding
DescriptionSP-lyase 1SPL 1hSPLsphingosine-1-phosphate aldolase
Modification date20141222
dbXrefs MIM : 603729
Ensembl : ENSG00000166224
HPRD : 07224
Vega : OTTHUMG00000018421
ProteinUniProt: O95470
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SGPL1
BioGPS: 8879
PathwayNCI Pathway Interaction Database: SGPL1
Pathway Commons: SGPL1
ContextiHOP: SGPL1
ligand binding site mutation search in PubMed: SGPL1
UCL Cancer Institute: SGPL1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006631fatty acid metabolic process24809814
GO:0006672ceramide metabolic process14570870
GO:0030149sphingolipid catabolic process24809814
GO:0097190apoptotic signaling pathway14570870

Ligand binding site mutations for SGPL1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SGPL1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SGPL1 from PDB

Differential gene expression and gene-gene network for SGPL1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SGPL1 and the right PPI network was created from samples without mutations in the LBS of SGPL1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SGPL1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SGPL1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
NutraceuticalDB00114Pyridoxal PhosphateSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SGPL1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of SGPL1
Multiple alignments for O95470 in multiple species
LBSAA sequence# speciesSpecies
A388QGGIYASPTIA1Homo sapiens
A388TGGLYGSPTLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A388SGGLYVSPTIA1Arabidopsis thaliana
A388TGGLYVSPTIA1Oryza sativa subsp. japonica
A388PGGVYGSPTVN1Drosophila melanogaster
A388QGGVYASPSIA1Mus musculus
A388QGGIYASPSIA1Rattus norvegicus
D176NPLHPDIFPGL3Homo sapiens, Mus musculus, Rattus norvegicus
D176NQLHPDVFPAV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D176NPLHIDVFQSV1Arabidopsis thaliana
D176NPLHQDVFKSV1Oryza sativa subsp. japonica
D176NPLHADLFPGV1Drosophila melanogaster
F545ELSSVFLDSLY1Homo sapiens
F545KLIVGFLDALY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F545ELLVSFMDSQY1Arabidopsis thaliana
F545ELLVEFMDASC1Oryza sativa subsp. japonica
F545EVTRLFLHSMY1Drosophila melanogaster
F545EISSVFLDCLY1Mus musculus
F545EISSVFLDSLY1Rattus norvegicus
H174WSNPLHPDIFP3Homo sapiens, Mus musculus, Rattus norvegicus
H174VANQLHPDVFP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H174HTNPLHIDVFQ1Arabidopsis thaliana
H174HTNPLHQDVFK1Oryza sativa subsp. japonica
H174YTNPLHADLFP1Drosophila melanogaster
I386DWQGGIYASPT1Homo sapiens
I386AWTGGLYGSPT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I386EWSGGLYVSPT1Arabidopsis thaliana
I386EWTGGLYVSPT1Oryza sativa subsp. japonica
I386DWPGGVYGSPT1Drosophila melanogaster
I386DWQGGVYASPS1Mus musculus
I386DWQGGIYASPS1Rattus norvegicus
I525TGMGAIYGMAQ3Homo sapiens, Mus musculus, Rattus norvegicus
I525DGTSALYGVAG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I525GGLAPIYGAAG1Arabidopsis thaliana
I525GGRAPIYGAAG1Oryza sativa subsp. japonica
I525VGKMALYGMAQ1Drosophila melanogaster
K353SADTHKYGYAP3Homo sapiens, Mus musculus, Rattus norvegicus
K353SCDTHKYGFAP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K353SVDVHKYGLAP1Arabidopsis thaliana
K353STDVHKYGLAP1Oryza sativa subsp. japonica
K353SADTHKYGFAP1Drosophila melanogaster
L173TWSNPLHPDIF2Mus musculus, Rattus norvegicus
L173AWSNPLHPDIF1Homo sapiens
L173CVANQLHPDVF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L173AHTNPLHIDVF1Arabidopsis thaliana
L173SHTNPLHQDVF1Oryza sativa subsp. japonica
L173SYTNPLHADLF1Drosophila melanogaster
L541NMVAELSSVFL1Homo sapiens
L541GVADKLIVGFL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L541GMVNELLVSFM1Arabidopsis thaliana
L541GMVRELLVEFM1Oryza sativa subsp. japonica
L541SVIGEVTRLFL1Drosophila melanogaster
L541KLVAEISSVFL1Mus musculus
L541KMVAEISSVFL1Rattus norvegicus
M528APIYGAAGKMP2Arabidopsis thaliana, Oryza sativa subsp. japonica
M528GAIYGMAQATI2Mus musculus, Rattus norvegicus
M528GAIYGMAQTTV1Homo sapiens
M528SALYGVAGSVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M528MALYGMAQSIP1Drosophila melanogaster
N171EFTWSNPLHPD2Mus musculus, Rattus norvegicus
N171DFAWSNPLHPD1Homo sapiens
N171KYCVANQLHPD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N171MFAHTNPLHID1Arabidopsis thaliana
N171MFSHTNPLHQD1Oryza sativa subsp. japonica
N171KASYTNPLHAD1Drosophila melanogaster
P175SNPLHPDIFPG3Homo sapiens, Mus musculus, Rattus norvegicus
P175ANQLHPDVFPA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P175TNPLHIDVFQS1Arabidopsis thaliana
P175TNPLHQDVFKS1Oryza sativa subsp. japonica
P175TNPLHADLFPG1Drosophila melanogaster
S542MVAELSSVFLD1Homo sapiens
S542VADKLIVGFLD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S542MVNELLVSFMD1Arabidopsis thaliana
S542MVRELLVEFMD1Oryza sativa subsp. japonica
S542VIGEVTRLFLH1Drosophila melanogaster
S542LVAEISSVFLD1Mus musculus
S542MVAEISSVFLD1Rattus norvegicus
T148GRASGTVYSGE1Homo sapiens
T148GKVSGAVYHGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T148GKCSGTVYIGG1Arabidopsis thaliana
T148GKCSGTVYIAG1Oryza sativa subsp. japonica
T148GRVSGAVYGYK1Drosophila melanogaster
T148GKASGAVYNGE1Mus musculus
T148GKASGAVYSGE1Rattus norvegicus
V538VDRNMVAELSS1Homo sapiens
V538KTAGVADKLIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V538PDRGMVNELLV1Arabidopsis thaliana
V538PDRGMVRELLV1Oryza sativa subsp. japonica
V538PDRSVIGEVTR1Drosophila melanogaster
V538IDRKLVAEISS1Mus musculus
V538IDRKMVAEISS1Rattus norvegicus
Y150ASGTVYSGEEK1Homo sapiens
Y150VSGAVYHGGDD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y150CSGTVYIGGAE1Arabidopsis thaliana
Y150CSGTVYIAGSE1Oryza sativa subsp. japonica
Y150VSGAVYGYKPD1Drosophila melanogaster
Y150ASGAVYNGEPK1Mus musculus
Y150ASGAVYSGEPK1Rattus norvegicus
Y387WQGGIYASPTI1Homo sapiens
Y387WTGGLYGSPTL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y387WSGGLYVSPTI1Arabidopsis thaliana
Y387WTGGLYVSPTI1Oryza sativa subsp. japonica
Y387WPGGVYGSPTV1Drosophila melanogaster
Y387WQGGVYASPSI1Mus musculus
Y387WQGGIYASPSI1Rattus norvegicus

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas