mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for CDC16

Gene summary

Basic gene Info.	Gene symbol	CDC16
	Gene name	cell division cycle 16
	Synonyms	ANAPC6\|APC6\|CUT9
	Cytomap	UCSC genome browser: 13q34
	Type of gene	protein-coding
	RefGenes	NM_001078645.1, NM_003903.3,
	Description	CDC16Hsanaphase-promoting complex subunit 6anaphase-promoting complex, subunit 6cell division cycle 16 homologcell division cycle protein 16 homologcyclosome subunit 6
	Modification date	20141207
dbXrefs	MIM : 603461
	HGNC : HGNC
	Ensembl : ENSG00000130177
	HPRD : 04587
	Vega : OTTHUMG00000017402
Protein	UniProt: Q13042 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_CDC16
	BioGPS: 8881
Pathway	NCI Pathway Interaction Database: CDC16
	KEGG: CDC16
	REACTOME: CDC16
	Pathway Commons: CDC16
Context	iHOP: CDC16
	ligand binding site mutation search in PubMed: CDC16
	UCL Cancer Institute: CDC16
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0070979	protein K11-linked ubiquitination	18485873

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Ligand binding site mutations for CDC16

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
M525	E524K	COAD	1
Y242	H241N	LUSC	1
M518	M518I	OV	1
V410	G409V	SKCM	1
M525	E524K	STAD	1
F413	Q414E	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for CDC16

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
M525	E524K	-1.2678338
Y242	H241N	-0.80630847
F413	Q414E	-0.60171685
M518	M518I	-0.57566521
V410	G409V	-0.22823964

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CDC16 from PDB

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Differential gene expression and gene-gene network for CDC16

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of CDC16 and the right PPI network was created from samples without mutations in the LBS of CDC16. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for CDC16

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for CDC16

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CDC16 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
III		Peptide ligand (MET,LEU,ARG,ARG,LYS,PRO,THR,ARG,LEU,GLU,LEU,LYS,LEU,ASP,ASP,ILE,GLU,GLU,PHE,GLU,ASN,ILE,ARG,LYS,ASP,LEU)	3hym	F	Y242 M518 M525
III		Peptide ligand (MET,LEU,ARG,ARG,LYS,PRO,THR,ARG,LEU,GLU,LEU,LYS,LEU,ASP,ASP,ILE,GLU,GLU,PHE,GLU,ASN,ILE,ARG)	3hym	L	Y242 V410 F413 M518
III		Peptide ligand (MET,LEU,ARG,ARG,LYS,PRO,THR,ARG,LEU,GLU,LEU,LYS,LEU,ASP,ASP,ILE,GLU,GLU,PHE,GLU,ASN,ILE,ARG,LYS,ASP)	4ui9	K	Y242 V410 F413 M518
III		Peptide ligand (MET,LEU,ARG,ARG,LYS,PRO,THR,ARG,LEU,GLU,LEU,LYS,LEU,ASP,ASP,ILE,GLU,GLU,PHE,GLU,ASN,ILE,ARG,LYS,ASP)	5a31	K	Y242 V410 F413 M518
III		Peptide ligand (MET,LEU,ARG,ARG,LYS,PRO,THR,ARG,LEU,GLU,LEU,LYS,LEU,ASP,ASP,ILE,GLU,GLU,PHE,GLU,ASN,ILE,ARG)	3hym	D	Y242 V410 F413 M518 M525
III		Peptide ligand (MET,LEU,ARG,ARG,LYS,PRO,THR,ARG,LEU,GLU,LEU,LYS,LEU,ASP,ASP,ILE,GLU,GLU,PHE,GLU,ASN,ILE,ARG,LYS,ASP)	3hym	H	Y242 V410 F413 M518 M525
III		Peptide ligand (MET,LEU,ARG,ARG,LYS,PRO,THR,ARG,LEU,GLU,LEU,LYS,LEU,GLU,ASP,ILE,GLU,GLU,PHE,GLU,ASN,ILE,ARG,LYS,ASP)	4ui9	J	Y242 V410 F413 M525
III		Peptide ligand (MET,LEU,ARG,ARG,LYS,PRO,THR,ARG,LEU,GLU,LEU,LYS,LEU,ASP,ASP,ILE,GLU,GLU,PHE,GLU,ASN,ILE,ARG,LYS,ASP)	5a31	J	Y242 V410 F413 M525
III		Peptide ligand (MET,LEU,ARG,ARG,LYS,PRO,THR,ARG,LEU,GLU,LEU,LYS,LEU,ASP,ASP,ILE,GLU,GLU,PHE,GLU,ASN,ILE,ARG,LYS,ASP,LEU)	3hym	J	Y242 V410 M518
III		Peptide ligand (MET,LEU,ARG,ARG,LYS,PRO,THR,ARG,LEU,GLU,LEU,LYS,LEU,ASP,ASP,ILE,GLU,GLU,PHE,GLU,ASN,ILE,ARG,LYS,ASP,LEU)	3hym	B	Y242 V410 M518 M525

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Conservation information for LBS of CDC16

Multiple alignments for Q13042 in multiple species

LBS	AA sequence	# species	Species
A339	GPAWIAYGHSF	2	Homo sapiens, Mus musculus
A339	SPARIGYGNSF	1	Arabidopsis thaliana
A339	AAAWLGFAHTY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A339	GPAWIGFAHSF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A345	YGHSFAVESEH	2	Homo sapiens, Mus musculus
A345	YGNSFAAQEEG	1	Arabidopsis thaliana
A345	FAHTYALEGEQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A345	FAHSFAIEGEH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A484	ASTYSAIGYIH	2	Homo sapiens, Mus musculus
A484	LSTYSGLAYTY	1	Arabidopsis thaliana
A484	SEIHCSLGYLY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A484	ANVHTAIALVY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C245	RHYYNCDFKMC	2	Homo sapiens, Mus musculus
C245	YYHQCCEYQKC	1	Arabidopsis thaliana
C245	ICYTQCKFNEC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C245	TLFVRSRFIDV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C307	WFAVGCYYLMV	2	Homo sapiens, Mus musculus
C307	WFAVGCYYYCI	1	Arabidopsis thaliana
C307	WFSVATYYMSL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C307	WLAVGIYYLCV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D401	SIAPEDPFVMH	1	Homo sapiens
D401	AICPSDPLVYN	1	Arabidopsis thaliana
D401	SIAPEDPFVIH	1	Mus musculus
D401	DICPNDPLVLN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D401	ALFQYDPLLLN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E239	VVSLAERHYYN	2	Homo sapiens, Mus musculus
E239	LACKAEYYHQC	1	Arabidopsis thaliana
E239	VRSKVDICYTQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E239	LLCKADTLFVR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E277	IGTLVELNKAN	2	Homo sapiens, Mus musculus
E277	LAAAMELGNSN	1	Arabidopsis thaliana
E277	IGCLYELSNKN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E277	LASLHESGEKN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E377	LYIGLEYGLTN	2	Homo sapiens, Mus musculus
E377	LYIGMEYMRTH	1	Arabidopsis thaliana
E377	LFLGMQFMAMN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E377	LFLGMQHMQLG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E407	PFVMHEVGVVA	1	Homo sapiens
E407	PLVYNELGVVA	1	Arabidopsis thaliana
E407	PFVIHEVGVVA	1	Mus musculus
E407	PLVLNEMGVMY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E407	PLLLNELGVVA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E445	TVDKWEPLLNN	2	Homo sapiens, Mus musculus
E445	LTESWEPTVVN	1	Arabidopsis thaliana
E445	SSRTTISIQLN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E445	NEKPWAATWAN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F303	NPVSWFAVGCY	2	Homo sapiens, Mus musculus
F303	KALSWFAVGCY	1	Arabidopsis thaliana
F303	SAITWFSVATY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F303	KAVTWLAVGIY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F403	APEDPFVMHEV	1	Homo sapiens
F403	CPSDPLVYNEL	1	Arabidopsis thaliana
F403	APEDPFVIHEV	1	Mus musculus
F403	CPNDPLVLNEM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F403	FQYDPLLLNEL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F413	VGVVAFQNGEW	2	Homo sapiens, Mus musculus
F413	LGVVAYHMKEY	1	Arabidopsis thaliana
F413	MGVMYFKKNEF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F413	LGVVAFNKSDM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F495	SLMGNFENAVD	2	Homo sapiens, Mus musculus
F495	HLQGNFSAAIS	1	Arabidopsis thaliana
F495	LKTKKLQKAID	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F495	LHKKIPGLAIT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F514	RRDDTFSVTML	2	Homo sapiens, Mus musculus
F514	KPDDQFCTEML	1	Arabidopsis thaliana
F514	KPNNSSATALL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F514	SPNEIMASDLL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G273	LPVHIGTLVEL	2	Homo sapiens, Mus musculus
G273	TLVHLAAAMEL	1	Arabidopsis thaliana
G273	LPAYIGCLYEL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G273	YPLHLASLHES	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H174	LLTSHHMLTAQ	2	Homo sapiens, Mus musculus
H174	CLIESHMLTSE	1	Arabidopsis thaliana
H174	MLLSKNLLTPQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H174	QLVSNHLLTAD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H342	WIAYGHSFAVE	2	Homo sapiens, Mus musculus
H342	RIGYGNSFAAQ	1	Arabidopsis thaliana
H342	WLGFAHTYALE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H342	WIGFAHSFAIE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H406	DPFVMHEVGVV	1	Homo sapiens
H406	DPLVYNELGVV	1	Arabidopsis thaliana
H406	DPFVIHEVGVV	1	Mus musculus
H406	DPLVLNEMGVM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H406	DPLLLNELGVV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H453	LNNLGHVCRKL	2	Homo sapiens, Mus musculus
H453	VVNLAHAYRKL	1	Arabidopsis thaliana
H453	QLNLGHTYRKL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H453	WANLGHAYRKL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H521	VTMLGHCIEMY	2	Homo sapiens, Mus musculus
H521	TEML-------	1	Arabidopsis thaliana
H521	TALLKNALELN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H521	SDLLKRALE--	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I338	YGPAWIAYGHS	2	Homo sapiens, Mus musculus
I338	FSPARIGYGNS	1	Arabidopsis thaliana
I338	FAAAWLGFAHT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I338	FGPAWIGFAHS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I475	QALVLIPQNAS	2	Homo sapiens, Mus musculus
I475	RALTLSTKSLS	1	Arabidopsis thaliana
I475	CVLEKNDKNSE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I475	QGLLLSTNDAN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K208	FLFENKLKKYN	1	Homo sapiens
K208	SFYSCLIKKYD	1	Arabidopsis thaliana
K208	FVFENKLKKYN	1	Mus musculus
K208	NLYKINLSKYI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K208	SLYMLKLNKTS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K443	EVTVDKWEPLL	2	Homo sapiens, Mus musculus
K443	-ALTESWEPTV	1	Arabidopsis thaliana
K443	DPSSRTTISIQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K443	QSNEKPWAATW	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K459	VCRKLKKYAEA	2	Homo sapiens, Mus musculus
K459	AYRKLRKDREA	1	Arabidopsis thaliana
K459	TYRKLNENEIA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K459	AYRKLKMYDAA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L310	VGCYYLMVGHK	2	Homo sapiens, Mus musculus
L310	VGCYYYCIKKY	1	Arabidopsis thaliana
L310	VATYYMSLDRI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L310	VGIYYLCVNKI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L369	MKGCHLPMLYI	2	Homo sapiens, Mus musculus
L369	FPGCHLPTLYI	1	Arabidopsis thaliana
L369	FPGMHLPKLFL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L369	FQGTHLPYLFL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L376	MLYIGLEYGLT	2	Homo sapiens, Mus musculus
L376	TLYIGMEYMRT	1	Arabidopsis thaliana
L376	KLFLGMQFMAM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L376	YLFLGMQHMQL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L491	GYIHSLMGNFE	2	Homo sapiens, Mus musculus
L491	AYTYHLQGNFS	1	Arabidopsis thaliana
L491	GYLYLKTKKLQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L491	ALVYLHKKIPG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M364	TAAQLMKGCHL	2	Homo sapiens, Mus musculus
M364	TAARLFPGCHL	1	Arabidopsis thaliana
M364	TASRFFPGMHL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M364	TAARLFQGTHL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M518	TFSVTMLGHCI	2	Homo sapiens, Mus musculus
M518	QFCTEML----	1	Arabidopsis thaliana
M518	SSATALLKNAL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M518	IMASDLLKRAL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M525	GHCIEMYIG--	2	Homo sapiens, Mus musculus
M525	-----------	1	Arabidopsis thaliana
M525	KNALELNVTLS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M525	KRALE------	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N449	WEPLLNNLGHV	2	Homo sapiens, Mus musculus
N449	WEPTVVNLAHA	1	Arabidopsis thaliana
N449	TISIQLNLGHT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N449	WAATWANLGHA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N450	EPLLNNLGHVC	2	Homo sapiens, Mus musculus
N450	EPTVVNLAHAY	1	Arabidopsis thaliana
N450	ISIQLNLGHTY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N450	AATWANLGHAY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N478	VLIPQNASTYS	2	Homo sapiens, Mus musculus
N478	TLSTKSLSTYS	1	Arabidopsis thaliana
N478	EKNDKNSEIHC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N478	LLSTNDANVHT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P269	HASCLPVHIGT	1	Homo sapiens
P269	HLKCTLVHLAA	1	Arabidopsis thaliana
P269	HANCLPVHIGT	1	Mus musculus
P269	NTNILPAYIGC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P269	NLDVYPLHLAS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P446	VDKWEPLLNNL	2	Homo sapiens, Mus musculus
P446	TESWEPTVVNL	1	Arabidopsis thaliana
P446	SRTTISIQLNL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P446	EKPWAATWANL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R456	LGHVCRKLKKY	2	Homo sapiens, Mus musculus
R456	LAHAYRKLRKD	1	Arabidopsis thaliana
R456	LGHTYRKLNEN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R456	LGHAYRKLKMY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S480	IPQNASTYSAI	2	Homo sapiens, Mus musculus
S480	STKSLSTYSGL	1	Arabidopsis thaliana
S480	NDKNSEIHCSL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S480	STNDANVHTAI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S483	NASTYSAIGYI	2	Homo sapiens, Mus musculus
S483	SLSTYSGLAYT	1	Arabidopsis thaliana
S483	NSEIHCSLGYL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S483	DANVHTAIALV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S490	IGYIHSLMGNF	2	Homo sapiens, Mus musculus
S490	LAYTYHLQGNF	1	Arabidopsis thaliana
S490	LGYLYLKTKKL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S490	IALVYLHKKIP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T481	PQNASTYSAIG	2	Homo sapiens, Mus musculus
T481	TKSLSTYSGLA	1	Arabidopsis thaliana
T481	DKNSEIHCSLG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T481	TNDANVHTAIA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T513	LRRDDTFSVTM	2	Homo sapiens, Mus musculus
T513	LKPDDQFCTEM	1	Arabidopsis thaliana
T513	LKPNNSSATAL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T513	ISPNEIMASDL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T517	DTFSVTMLGHC	2	Homo sapiens, Mus musculus
T517	DQFCTEML---	1	Arabidopsis thaliana
T517	NSSATALLKNA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T517	EIMASDLLKRA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V410	MHEVGVVAFQN	1	Homo sapiens
V410	YNELGVVAYHM	1	Arabidopsis thaliana
V410	IHEVGVVAFQN	1	Mus musculus
V410	LNEMGVMYFKK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V410	LNELGVVAFNK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W444	VTVDKWEPLLN	2	Homo sapiens, Mus musculus
W444	ALTESWEPTVV	1	Arabidopsis thaliana
W444	PSSRTTISIQL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W444	SNEKPWAATWA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y242	LAERHYYNCDF	2	Homo sapiens, Mus musculus
Y242	KAEYYHQCCEY	1	Arabidopsis thaliana
Y242	KVDICYTQCKF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y242	KADTLFVRSRF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y243	AERHYYNCDFK	2	Homo sapiens, Mus musculus
Y243	AEYYHQCCEYQ	1	Arabidopsis thaliana
Y243	VDICYTQCKFN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y243	ADTLFVRSRFI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y357	QAMAAYFTAAQ	2	Homo sapiens, Mus musculus
Y357	QAMSAYRTAAR	1	Arabidopsis thaliana
Y357	QALTAYSTASR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y357	QAISAYTTAAR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y373	HLPMLYIGLEY	2	Homo sapiens, Mus musculus
Y373	HLPTLYIGMEY	1	Arabidopsis thaliana
Y373	HLPKLFLGMQF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y373	HLPYLFLGMQH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y461	RKLKKYAEALD	2	Homo sapiens, Mus musculus
Y461	RKLRKDREAIS	1	Arabidopsis thaliana
Y461	RKLNENEIAIK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y461	RKLKMYDAAID	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y487	YSAIGYIHSLM	2	Homo sapiens, Mus musculus
Y487	YSGLAYTYHLQ	1	Arabidopsis thaliana
Y487	HCSLGYLYLKT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y487	HTAIALVYLHK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)