mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CCNA2
Gene summary
Basic gene Info.Gene symbolCCNA2
Gene namecyclin A2
SynonymsCCN1|CCNA
CytomapUCSC genome browser: 4q27
Type of geneprotein-coding
RefGenesNM_001237.3,
Descriptioncyclin-Acyclin-A2
Modification date20141222
dbXrefs MIM : 123835
HGNC : HGNC
Ensembl : ENSG00000145386
HPRD : 00453
Vega : OTTHUMG00000133072
ProteinUniProt: P20248
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CCNA2
BioGPS: 890
PathwayNCI Pathway Interaction Database: CCNA2
KEGG: CCNA2
REACTOME: CCNA2
Pathway Commons: CCNA2
ContextiHOP: CCNA2
ligand binding site mutation search in PubMed: CCNA2
UCL Cancer Institute: CCNA2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for CCNA2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
T207T207SCOAD1
E220E220KLUAD1
Y286K288NUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CCNA2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T207T207S-1.1278253
E220E220K-0.88470354
Y286K288N-0.83470109
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CCNA2 from PDB

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Differential gene expression and gene-gene network for CCNA2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CCNA2 and the right PPI network was created from samples without mutations in the LBS of CCNA2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CCNA2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C3714756Intellectual Disability1Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CCNA2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB020914-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-YlamineSmall molecule
ExperimentalDB024076-O-Cyclohexylmethyl GuanineSmall molecule
ExperimentalDB02833[4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-AmineSmall molecule
ExperimentalDB029154-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(4-Trifluoromethyl-Phenyl)-AmineSmall molecule
ExperimentalDB068444-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDESmall molecule
ExperimentalDB06944N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamideSmall molecule
ExperimentalDB069482-ANILINO-6-CYCLOHEXYLMETHOXYPURINESmall molecule
ExperimentalDB07126O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINESmall molecule
ExperimentalDB07137(2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDESmall molecule
ExperimentalDB07164N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amineSmall molecule
ExperimentalDB072036-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINESmall molecule
ExperimentalDB074715-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDESmall molecule
ExperimentalDB075334-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDESmall molecule
ExperimentalDB075344-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDESmall molecule
ExperimentalDB075384-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDESmall molecule
ExperimentalDB075394-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACIDSmall molecule
ExperimentalDB07562N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINESmall molecule
ExperimentalDB076884-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDESmall molecule
ExperimentalDB078521-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACIDSmall molecule
ExperimentalDB081784-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineSmall molecule
ExperimentalDB081824-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineSmall molecule
ExperimentalDB08218HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUMSmall molecule
ExperimentalDB082194-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINESmall molecule
ExperimentalDB082336-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINESmall molecule
ExperimentalDB082414-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDESmall molecule
ExperimentalDB082483-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDESmall molecule
ExperimentalDB08285(2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-olSmall molecule
ExperimentalDB083093-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OLSmall molecule
ExperimentalDB083551-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acidSmall molecule
ExperimentalDB08463(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-olSmall molecule
ExperimentalDB085271-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDESmall molecule
ExperimentalDB085724-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDESmall molecule
ExperimentalDB086949-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-olSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CCNA2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (PRO,VAL,LYS,ARG,ARG,LEU,ASP,LEU,GLU)1h24BE220
IIIPeptide ligand (ARG,ASN,LEU,PHE,GLY,PRO)1h27BE220
IIIPeptide ligand (ALA,LYS,ARG,ARG,LEU,PHE,GLY,GLU)1h28DE220
IIIPeptide ligand (ARG,ARG,LEU,ILE,PHE,NH2)1okvBE220
IIIPeptide ligand (ARG,ARG,LEU,ILE,PHE,NH2)1okvDE220
IIIPeptide ligand (ACE,ARG,ARG,LEU,ASN,PHE,NH2)1okwBE220
IIIPeptide ligand (ACE,ARG,ARG,LEU,ASN,PHE,NH2)1okwDE220
IIIPeptide ligand (ARG,ARG,LEU,ASN,PFF,NH2)1ol2BE220
IIIPeptide ligand (ARG,ARG,LEU,ASN,PFF,NH2)1ol2DE220
IIIPeptide ligand (ACE,ARG,LYS,LEU,PHE,GLY)1urcBE220
IIIPeptide ligand (ALA,ALA,GLU,ARG,SER,LEU,ILE,PHE,NH2)2c5vBE220
IIIPeptide ligand (ALA,ALA,GLU,ARG,SER,LEU,ILE,PHE,NH2)2c5vDE220
IIIPeptide ligand (HIS,THR,LEU,LYS,GLY,ARG,ARG,LEU,VAL,PHE,ASP,ASN)2cchBE220
IIIPeptide ligand (HIS,THR,LEU,LYS,GLY,ARG,ARG,LEU,VAL,PHE,ASP,ASN)2cchDE220
IIIPeptide ligand (THR,LEU,LYS,GLY,ARG,ARG,LEU,VAL,PHE)2cciDE220
GVC1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID2uueBE220
GVC1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID2uueDE220
IIIPeptide ligand (ACE,ARG,ARG,LEU,PHE,NH2)2wfyBE220
IIIPeptide ligand (ACE,ARG,ARG,LEU,PHE,NH2)2wfyDE220
IIIPeptide ligand (ARG,ARG,LEU,PHE,NH2)2whbBE220
IIIPeptide ligand (ARG,ARG,LEU,PHE,NH2)2whbDE220
IIIPeptide ligand (ARG,LYS,LEU,PHE,ASN)2wmaBE220
IIIPeptide ligand (GLY,SER,ALA,LYS,ARG,ARG,LEU,PHE,GLY,GLU)1h28BE220 Y286
IIIPeptide ligand (HIS,THR,LEU,LYS,GLY,ARG,ARG,LEU,VAL,PHE,ASP,ASN)2cciBT207 E220


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Conservation information for LBS of CCNA2
Multiple alignments for P20248 in multiple species
LBSAA sequence# speciesSpecies
D216RAILVDWLVEV4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
D216RGILVDWLVEV2Arabidopsis thaliana, Arabidopsis thaliana
D216RGILIDWLVEV1Oryza sativa subsp. japonica
D283FVYITDDTYTK2Homo sapiens, Bos taurus
D283FCFITDNTYTR2Arabidopsis thaliana, Arabidopsis thaliana
D283FVYITDDTYNK1Gallus gallus
D283FVYITDDTYSK1Mus musculus
D283FCFITDNTYTK1Oryza sativa subsp. japonica
E220VDWLVEVGEEY4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
E220VDWLVEVSEEY2Arabidopsis thaliana, Arabidopsis thaliana
E220IDWLVEVSEEY1Oryza sativa subsp. japonica
E223LVEVGEEYKLQ4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
E223LVEVSEEYKLV1Oryza sativa subsp. japonica
E223LVEVSEEYTLA1Arabidopsis thaliana
E223LVEVSEEYTLV1Arabidopsis thaliana
E224VEVGEEYKLQN4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
E224VEVSEEYKLVP1Oryza sativa subsp. japonica
E224VEVSEEYTLAS1Arabidopsis thaliana
E224VEVSEEYTLVP1Arabidopsis thaliana
E269ASKFEEIYPPE4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
E269ASKYEEICAPR1Oryza sativa subsp. japonica
E269ASKYEEISAPR1Arabidopsis thaliana
E269ASKYEEIHAPR1Arabidopsis thaliana
E277PPEVAEFVYIT4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
E277APRIEEFCFIT2Arabidopsis thaliana, Arabidopsis thaliana
E277APRVEEFCFIT1Oryza sativa subsp. japonica
G251MSVLRGKLQLV4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
G251HYIERQKLQLL1Oryza sativa subsp. japonica
G251NYVQRQQLQLL1Arabidopsis thaliana
G251NYVERQRLQLL1Arabidopsis thaliana
I206K-QPDITNSMR2Homo sapiens, Bos taurus
I206K-QPDITNNMR1Gallus gallus
I206R-QPDITNSMR1Mus musculus
I206ALQRDITKGMR1Oryza sativa subsp. japonica
I206RIQKDVTQSMR1Arabidopsis thaliana
I206KTQRDVTETMR1Arabidopsis thaliana
I213NSMRAILVDWL3Homo sapiens, Mus musculus, Bos taurus
I213NNMRAILVDWL1Gallus gallus
I213KGMRGILIDWL1Oryza sativa subsp. japonica
I213QSMRGILVDWL1Arabidopsis thaliana
I213ETMRGILVDWL1Arabidopsis thaliana
I270SKFEEIYPPEV4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
I270SKYEEICAPRV1Oryza sativa subsp. japonica
I270SKYEEISAPRI1Arabidopsis thaliana
I270SKYEEIHAPRI1Arabidopsis thaliana
I281AEFVYITDDTY4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
I281EEFCFITDNTY3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
K252SVLRGKLQLVG4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
K252YIERQKLQLLG1Oryza sativa subsp. japonica
K252YVQRQQLQLLG1Arabidopsis thaliana
K252YVERQRLQLLG1Arabidopsis thaliana
L214SMRAILVDWLV3Homo sapiens, Mus musculus, Bos taurus
L214NMRAILVDWLV1Gallus gallus
L214GMRGILIDWLV1Oryza sativa subsp. japonica
L214SMRGILVDWLV1Arabidopsis thaliana
L214TMRGILVDWLV1Arabidopsis thaliana
L253VLRGKLQLVGT4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
L253IERQKLQLLGI1Oryza sativa subsp. japonica
L253VQRQQLQLLGI1Arabidopsis thaliana
L253VERQRLQLLGI1Arabidopsis thaliana
L348DADPYLKYLPS4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
L348DY-SFLKFLPS1Oryza sativa subsp. japonica
L348DY-HFLKFLPS1Arabidopsis thaliana
L348DY-PFLKFLPS1Arabidopsis thaliana
M200PKVGYMKK-QP2Homo sapiens, Bos taurus
M200PKIGYMKK-QP1Gallus gallus
M200PKVGYMKR-QP1Mus musculus
M200PRSNYMEALQR1Oryza sativa subsp. japonica
M200PLPDFMERIQK1Arabidopsis thaliana
M200PFPDFMEKTQR1Arabidopsis thaliana
M210DITNSMRAILV3Homo sapiens, Mus musculus, Bos taurus
M210DITNNMRAILV1Gallus gallus
M210DITKGMRGILI1Oryza sativa subsp. japonica
M210DVTQSMRGILV1Arabidopsis thaliana
M210DVTETMRGILV1Arabidopsis thaliana
Q203YMKK-QPDITN3Homo sapiens, Gallus gallus, Bos taurus
Q203YMKR-QPDITN1Mus musculus
Q203YMEALQRDITK1Oryza sativa subsp. japonica
Q203FMERIQKDVTQ1Arabidopsis thaliana
Q203FMEKTQRDVTE1Arabidopsis thaliana
Q254LRGKLQLVGTA4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
Q254ERQKLQLLGIT1Oryza sativa subsp. japonica
Q254QRQQLQLLGIT1Arabidopsis thaliana
Q254ERQRLQLLGIT1Arabidopsis thaliana
R250SMSVLRGKLQL4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
R250QHYIERQKLQL1Oryza sativa subsp. japonica
R250GNYVQRQQLQL1Arabidopsis thaliana
R250GNYVERQRLQL1Arabidopsis thaliana
T207-QPDITNSMRA3Homo sapiens, Mus musculus, Bos taurus
T207-QPDITNNMRA1Gallus gallus
T207LQRDITKGMRG1Oryza sativa subsp. japonica
T207IQKDVTQSMRG1Arabidopsis thaliana
T207TQRDVTETMRG1Arabidopsis thaliana
T282EFCFITDNTYT3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
T282EFVYITDDTYT2Homo sapiens, Bos taurus
T282EFVYITDDTYN1Gallus gallus
T282EFVYITDDTYS1Mus musculus
T285YITDDTYTKKQ2Homo sapiens, Bos taurus
T285FITDNTYTRDQ2Arabidopsis thaliana, Arabidopsis thaliana
T285YITDDTYNKKQ1Gallus gallus
T285YITDDTYSKKQ1Mus musculus
T285FITDNTYTKAE1Oryza sativa subsp. japonica
V221DWLVEVGEEYK4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
V221DWLVEVSEEYT2Arabidopsis thaliana, Arabidopsis thaliana
V221DWLVEVSEEYK1Oryza sativa subsp. japonica
W217AILVDWLVEVG4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
W217GILVDWLVEVS2Arabidopsis thaliana, Arabidopsis thaliana
W217GILIDWLVEVS1Oryza sativa subsp. japonica
Y225EVGEEYKLQNE4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
Y225EVSEEYKLVPD1Oryza sativa subsp. japonica
Y225EVSEEYTLASD1Arabidopsis thaliana
Y225EVSEEYTLVPD1Arabidopsis thaliana
Y280VAEFVYITDDT4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
Y280IEEFCFITDNT2Arabidopsis thaliana, Arabidopsis thaliana
Y280VEEFCFITDNT1Oryza sativa subsp. japonica
Y286ITDDTYTKKQV2Homo sapiens, Bos taurus
Y286ITDNTYTRDQV2Arabidopsis thaliana, Arabidopsis thaliana
Y286ITDDTYNKKQV1Gallus gallus
Y286ITDDTYSKKQV1Mus musculus
Y286ITDNTYTKAEV1Oryza sativa subsp. japonica
Y347IDADPYLKYLP4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
Y347IDY-SFLKFLP1Oryza sativa subsp. japonica
Y347IDY-HFLKFLP1Arabidopsis thaliana
Y347MDY-PFLKFLP1Arabidopsis thaliana
Y350DPYLKYLPSVI3Homo sapiens, Gallus gallus, Bos taurus
Y350DPYLKYLPSLI1Mus musculus
Y350-SFLKFLPSVV1Oryza sativa subsp. japonica
Y350-HFLKFLPSVV1Arabidopsis thaliana
Y350-PFLKFLPSII1Arabidopsis thaliana


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