mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for HIST1H2BJ

Gene summary

Basic gene Info.	Gene symbol	HIST1H2BJ
	Gene name	histone cluster 1, H2bj
	Synonyms	H2B/r\|H2BFR\|H2BJ
	Cytomap	UCSC genome browser: 6p22.1
	Type of gene	protein-coding
	RefGenes	NM_021058.3,
	Description	H2B histone family, member Rhistone 1, H2bjhistone H2B type 1-Jhistone H2B.1histone H2B.r
	Modification date	20141218
dbXrefs	MIM : 615044
	HGNC : HGNC
	HPRD : 13657
Protein	UniProt: P06899 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_HIST1H2BJ
	BioGPS: 8970
Pathway	NCI Pathway Interaction Database: HIST1H2BJ
	KEGG: HIST1H2BJ
	REACTOME: HIST1H2BJ
	Pathway Commons: HIST1H2BJ
Context	iHOP: HIST1H2BJ
	ligand binding site mutation search in PubMed: HIST1H2BJ
	UCL Cancer Institute: HIST1H2BJ
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0002227	innate immune response in mucosa	12860195
GO:0019731	antibacterial humoral response	12860195
GO:0050830	defense response to Gram-positive bacterium	12860195

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Ligand binding site mutations for HIST1H2BJ

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
M60	M60L	BRCA	1
K6	P4T	HNSC	1
S33	S33N	KIRC	1
G54	G54D	KIRC	1
Q48	K47T	LUAD	1
Q48	Q48H	LUAD	1
D69	F71L	LUSC	1
S88	S88P	STAD	1
G54	G54D	THCA	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for HIST1H2BJ

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
K6	P4T	-1.3176114
Q48	Q48H	-1.0458386
D69	F71L	-0.88168801
S33	S33N	-0.82619334
S88	S88P	-0.67510932
G54	G54D	-0.67344163
Q48	K47T	-0.55874563
M60	M60L	-0.51117825

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HIST1H2BJ from PDB

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Differential gene expression and gene-gene network for HIST1H2BJ

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of HIST1H2BJ and the right PPI network was created from samples without mutations in the LBS of HIST1H2BJ. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for HIST1H2BJ

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for HIST1H2BJ

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HIST1H2BJ go to BioLip

Ligand ID

Ligand short name

Ligand long name

PDB ID

PDB name

mutLBS

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Conservation information for LBS of HIST1H2BJ

Multiple alignments for P06899 in multiple species

LBS	AA sequence	# species	Species
D69	NSFVNDIFERI	30	Homo sapiens, Mus musculus, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Dr
D69	NSFVNDVFERI	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
E36	RK-RKESYAIY	23	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
E36	HA-RKESYSVY	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
E36	RKTRKESYAIY	5	Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae
E36	RS-RKESYSIY	2	Homo sapiens, Mus musculus
F66	SIMNSFVNDIF	28	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
F66	SIMNSFVNDVF	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
F66	GIMNSFVNDIF	2	Homo sapiens, Mus musculus
G54	VHPDTGISSKA	30	Homo sapiens, Mus musculus, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Dr
G54	VHPDTGVSSKA	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
G61	SSKAMSIMNSF	44	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
G61	SSKAMGIMNSF	2	Homo sapiens, Mus musculus
H50	VLKQVHPDTGI	30	Homo sapiens, Mus musculus, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Dr
H50	VLKQVHPDTGV	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
I40	KESYAIYIYKV	28	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
I40	KESYSVYIYRV	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
I40	KESYSIYVYKV	2	Homo sapiens, Mus musculus
I55	HPDTGISSKAM	30	Homo sapiens, Mus musculus, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Dr
I55	HPDTGVSSKAM	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
I62	SKAMSIMNSFV	44	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
I62	SKAMGIMNSFV	2	Homo sapiens, Mus musculus
K31	TDKKKKRK-RK	23	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
K31	DGKKRRHA-RK	15	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
K31	SDKKKKRKTRK	5	Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae
K31	DGKKRKRS-RK	2	Homo sapiens, Mus musculus
K31	DGKKRKHA-RK	1	Caenorhabditis elegans
K35	KRK-RKESYAI	23	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
K35	RHA-RKESYSV	15	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
K35	KRKTRKESYAI	5	Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae
K35	KRS-RKESYSI	2	Homo sapiens, Mus musculus
K35	KHA-RKESYSV	1	Caenorhabditis elegans
K58	TGISSKAMSIM	28	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
K58	TGVSSKAMSIM	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
K58	TGISSKAMGIM	2	Homo sapiens, Mus musculus
K6	-MPPKTSGKAA	23	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
K6	-MPPKPSAKGA	9	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans
K6	MAPPKPSAKGA	7	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans
K6	-MAPKTSGKAA	5	Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae
K6	MPEPAKSAPAP	1	Homo sapiens
K6	MPELAKSAPAP	1	Mus musculus
M60	ISSKAMSIMNS	28	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
M60	VSSKAMSIMNS	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
M60	ISSKAMGIMNS	2	Homo sapiens, Mus musculus
Q48	YKVLKQVHPDT	30	Homo sapiens, Mus musculus, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Dr
Q48	YRVLKQVHPDT	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
R30	KTDKKKKRK-R	23	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
R30	KDGKKRRHA-R	15	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
R30	KSDKKKKRKTR	5	Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae
R30	KDGKKRKRS-R	2	Homo sapiens, Mus musculus
R30	KDGKKRKHA-R	1	Caenorhabditis elegans
R32	DKKKKRK-RKE	23	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
R32	GKKRRHA-RKE	15	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
R32	DKKKKRKTRKE	5	Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae
R32	GKKRKRS-RKE	2	Homo sapiens, Mus musculus
R32	GKKRKHA-RKE	1	Caenorhabditis elegans
R34	KKRK-RKESYA	23	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
R34	RRHA-RKESYS	15	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
R34	KKRKTRKESYA	5	Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae
R34	RKRS-RKESYS	2	Homo sapiens, Mus musculus
R34	RKHA-RKESYS	1	Caenorhabditis elegans
R87	AHYNKRSTITS	30	Homo sapiens, Mus musculus, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Dr
R87	AHYNKRSTISS	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
S33	KKKKRK-RKES	23	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
S33	KKRRHA-RKES	15	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
S33	KKKKRKTRKES	5	Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae
S33	KKRKRS-RKES	2	Homo sapiens, Mus musculus
S33	KKRKHA-RKES	1	Caenorhabditis elegans
S37	K-RKESYAIYI	23	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
S37	A-RKESYSVYI	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
S37	KTRKESYAIYI	5	Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae, Anopheles gambiae
S37	S-RKESYSIYV	2	Homo sapiens, Mus musculus
S39	RKESYAIYIYK	28	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
S39	RKESYSVYIYR	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
S39	RKESYSIYVYK	2	Homo sapiens, Mus musculus
S56	PDTGISSKAMS	28	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
S56	PDTGVSSKAMS	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
S56	PDTGISSKAMG	2	Homo sapiens, Mus musculus
S57	DTGISSKAMSI	28	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
S57	DTGVSSKAMSI	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
S57	DTGISSKAMGI	2	Homo sapiens, Mus musculus
S65	MSIMNSFVNDI	28	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
S65	MSIMNSFVNDV	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
S65	MGIMNSFVNDI	2	Homo sapiens, Mus musculus
S88	HYNKRSTITSR	30	Homo sapiens, Mus musculus, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Dr
S88	HYNKRSTISSR	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
T89	YNKRSTITSRE	30	Homo sapiens, Mus musculus, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Dr
T89	YNKRSTISSRE	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
V49	KVLKQVHPDTG	30	Homo sapiens, Mus musculus, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Dr
V49	RVLKQVHPDTG	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
Y41	ESYAIYIYKVL	28	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
Y41	ESYSVYIYRVL	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
Y41	ESYSIYVYKVL	2	Homo sapiens, Mus musculus
Y43	YAIYIYKVLKQ	28	Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Droso
Y43	YSVYIYRVLKQ	16	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
Y43	YSIYVYKVLKQ	2	Homo sapiens, Mus musculus