mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for UBA3
Gene summary
Basic gene Info.Gene symbolUBA3
Gene nameubiquitin-like modifier activating enzyme 3
SynonymsNAE2|UBE1C|hUBA3
CytomapUCSC genome browser: 3p14.1
Type of geneprotein-coding
RefGenesNM_003968.3,
NM_198195.1,NM_198197.1,
DescriptionNEDD8-activating enzyme E1 catalytic subunitNEDD8-activating enzyme E1 subunit 2NEDD8-activating enzyme E1CNedd8-activating enzyme hUba3UBA3, ubiquitin-activating enzyme E1 homologubiquitin-activating enzyme 3ubiquitin-activating enzyme E1C (UBA3 ho
Modification date20141207
dbXrefs MIM : 603172
HGNC : HGNC
Ensembl : ENSG00000144744
HPRD : 04413
Vega : OTTHUMG00000154325
ProteinUniProt: Q8TBC4
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_UBA3
BioGPS: 9039
PathwayNCI Pathway Interaction Database: UBA3
KEGG: UBA3
REACTOME: UBA3
Pathway Commons: UBA3
ContextiHOP: UBA3
ligand binding site mutation search in PubMed: UBA3
UCL Cancer Institute: UBA3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for UBA3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S62L63VBLCA1
Q149D150HBRCA1
S334A335TCOAD1
R157R157QCOAD1
G79G79SLUAD1
E357,K361E359KSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for UBA3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Q149D150H-1.3190198
K361E359K-1.0329617
E357E359K-1.0329617
R157R157Q-1.0084165
S334A335T-0.88787101
G79G79S-0.78909175
S62L63V-0.78676346
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for UBA3 from PDB

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Differential gene expression and gene-gene network for UBA3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of UBA3 and the right PPI network was created from samples without mutations in the LBS of UBA3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for UBA3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for UBA3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of UBA3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
B39[(1S,2S,4R)-4-{4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL]METHYL SULFAMATE3gznBG79 Q149
B39[(1S,2S,4R)-4-{4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL]METHYL SULFAMATE3gznDG79 Q149


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Conservation information for LBS of UBA3
Multiple alignments for Q8TBC4 in multiple species
LBSAA sequence# speciesSpecies
A171LDSIIARRWIN3Homo sapiens, Mus musculus, Rattus norvegicus
A171LDSVEARRWIN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A171LDSIEARKYIN1Arabidopsis thaliana
A171LDSIPARRWIN1Caenorhabditis elegans
A171LDSIVARRWIN1Drosophila melanogaster
A171LDSVIARRWMN1Danio rerio
A332EVFKIATSAYI3Homo sapiens, Mus musculus, Rattus norvegicus
A332EALKILTESNP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A332ETLKIVSACSK1Arabidopsis thaliana
A332EALKLATNIAK1Caenorhabditis elegans
A332EVFKLATSCYD1Drosophila melanogaster
A332EVFKIATSAYV1Danio rerio
A77VLVIGAGGLGC3Homo sapiens, Mus musculus, Rattus norvegicus
A77ILVIGAGGLGC3Arabidopsis thaliana, Caenorhabditis elegans, Danio rerio
A77ILIIGAGGLGC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A77VLIIGAGGLGC1Drosophila melanogaster
C220PGMTACIECTL3Homo sapiens, Mus musculus, Rattus norvegicus
C220PTITSCYECSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C220PGVTPCFECTI1Arabidopsis thaliana
C220PKFTACIDCTL1Caenorhabditis elegans
C220PGFTACIECTL1Drosophila melanogaster
C220PGMTACIDCTL1Danio rerio
C223TACIECTLELY3Homo sapiens, Mus musculus, Rattus norvegicus
C223TSCYECSLDML1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C223TPCFECTIYLF1Arabidopsis thaliana
C223TACIDCTLDLY1Caenorhabditis elegans
C223TACIECTLDLF1Drosophila melanogaster
C223TACIDCTLELY1Danio rerio
C364ERKENCPACSQ3Homo sapiens, Mus musculus, Rattus norvegicus
C364EKRSDCPVCGV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C364ERDTECLVCGP1Arabidopsis thaliana
C364MKDDNCLTCSG1Caenorhabditis elegans
C364EKSENCLACSN1Drosophila melanogaster
C364ERKENCSACSQ1Danio rerio
C367ENCPACSQLPQ3Homo sapiens, Mus musculus, Rattus norvegicus
C367SDCPVCGVLSE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C367TECLVCGPGIL1Arabidopsis thaliana
C367DNCLTCSGGRL1Caenorhabditis elegans
C367ENCLACSNTPQ1Drosophila melanogaster
C367ENCSACSQVPQ1Danio rerio
C70FLLDTCKVLVI3Homo sapiens, Mus musculus, Rattus norvegicus
C70SAFSS-KILII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C70DIRDYVRILVI1Arabidopsis thaliana
C70ALQNT-KILVI1Caenorhabditis elegans
C70FLQTKCQVLII1Drosophila melanogaster
C70FLLDTCKILVI1Danio rerio
D100QIHVIDMDTID3Homo sapiens, Mus musculus, Rattus norvegicus
D100DLSVIDMDTID1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D100NLEVIDMDRIE1Arabidopsis thaliana
D100TIEVIDMDTID1Caenorhabditis elegans
D100NLHVIDMDTIE1Drosophila melanogaster
D100HIHVVDMDTID1Danio rerio
D102HVIDMDTIDVS3Homo sapiens, Mus musculus, Rattus norvegicus
D102SVIDMDTIDIT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D102EVIDMDRIEVT1Arabidopsis thaliana
D102EVIDMDTIDVS1Caenorhabditis elegans
D102HVIDMDTIELS1Drosophila melanogaster
D102HVVDMDTIDVS1Danio rerio
D167IVCGLDSIIAR3Homo sapiens, Mus musculus, Rattus norvegicus
D167IICGLDSVEAR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D167IALGLDSIEAR1Arabidopsis thaliana
D167IICGLDSIPAR1Caenorhabditis elegans
D167VVCGLDSIVAR1Drosophila melanogaster
D167VVCGLDSVIAR1Danio rerio
D55PFTHPDFEPST3Homo sapiens, Mus musculus, Rattus norvegicus
D55PFNLDAPENPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D55NLVDPGFVPGP1Arabidopsis thaliana
D55AYKVPWFVPGP1Caenorhabditis elegans
D55PFCKDGFAASS1Drosophila melanogaster
D55PFTHPDFEAST1Danio rerio
E357YTYTFEAERKE4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
E357YTYTFNLEKRS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E357YTEVTKFERDT1Arabidopsis thaliana
E357YTSVVSMMKDD1Caenorhabditis elegans
E357YTYTYEAEKSE1Drosophila melanogaster
F159TFYRQFHIIVC3Homo sapiens, Mus musculus, Rattus norvegicus
F159EFYKEFKLIIC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F159EFYNDFNIIAL1Arabidopsis thaliana
F159EFYRKFSIIIC1Caenorhabditis elegans
F159SFYQQFHLVVC1Drosophila melanogaster
F159TFYRQFHIVVC1Danio rerio
F65TESLQFLLDTC4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
F65EETLKSAFSS-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F65PGLRDDIRDYV1Arabidopsis thaliana
F65PENFEALQNT-1Caenorhabditis elegans
F65SENLEFLQTKC1Drosophila melanogaster
G165HIIVCGLDSII3Homo sapiens, Mus musculus, Rattus norvegicus
G165KLIICGLDSVE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G165NIIALGLDSIE1Arabidopsis thaliana
G165SIIICGLDSIP1Caenorhabditis elegans
G165HLVVCGLDSIV1Drosophila melanogaster
G165HIVVCGLDSVI1Danio rerio
G76KVLVIGAGGLG3Homo sapiens, Mus musculus, Rattus norvegicus
G76KILVIGAGGLG2Caenorhabditis elegans, Danio rerio
G76KILIIGAGGLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G76RILVIGAGGLG1Arabidopsis thaliana
G76QVLIIGAGGLG1Drosophila melanogaster
G78LVIGAGGLGCE6Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Danio rerio, Mus musculus, Rattus norvegicus
G78LIIGAGGLGCE2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
G79VIGAGGLGCEL6Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Danio rerio, Mus musculus, Rattus norvegicus
G79IIGAGGLGCEI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G79IIGAGGLGCEL1Drosophila melanogaster
H160FYRQFHIIVCG3Homo sapiens, Mus musculus, Rattus norvegicus
H160FYKEFKLIICG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H160FYNDFNIIALG1Arabidopsis thaliana
H160FYRKFSIIICG1Caenorhabditis elegans
H160FYQQFHLVVCG1Drosophila melanogaster
H160FYRQFHIVVCG1Danio rerio
H53SGPFTHPDFEP3Homo sapiens, Mus musculus, Rattus norvegicus
H53PGPFNLDAPEN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H53HGNLVDPGFVP1Arabidopsis thaliana
H53DSAYKVPWFVP1Caenorhabditis elegans
H53EGPFCKDGFAA1Drosophila melanogaster
H53TGPFTHPDFEA1Danio rerio
I148PHFNKIQDFND3Homo sapiens, Mus musculus, Rattus norvegicus
I148PFYGKIQDKTI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I148PHFSRIEDKEI1Arabidopsis thaliana
I148AHNCRIEDKGQ1Caenorhabditis elegans
I148PHFKKIQDFDE1Drosophila melanogaster
I148PHFKKIQDLDE1Danio rerio
I161YRQFHIIVCGL3Homo sapiens, Mus musculus, Rattus norvegicus
I161YKEFKLIICGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I161YNDFNIIALGL1Arabidopsis thaliana
I161YRKFSIIICGL1Caenorhabditis elegans
I161YQQFHLVVCGL1Drosophila melanogaster
I161YRQFHIVVCGL1Danio rerio
I170GLDSIIARRWI3Homo sapiens, Mus musculus, Rattus norvegicus
I170GLDSVEARRWI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I170GLDSIEARKYI1Arabidopsis thaliana
I170GLDSIPARRWI1Caenorhabditis elegans
I170GLDSIVARRWI1Drosophila melanogaster
I170GLDSVIARRWM1Danio rerio
I195LDPSSIVPLID3Homo sapiens, Mus musculus, Rattus norvegicus
I195AKTGDLIPLVD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I195PKRETIKPMVD1Arabidopsis thaliana
I195PDENTIIPMID1Caenorhabditis elegans
I195IDTSSIVPMID1Drosophila melanogaster
I195LDPSSIIPLID1Danio rerio
I331TEVFKIATSAY4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
I331NEALKILTESN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I331LETLKIVSACS1Arabidopsis thaliana
I331LEALKLATNIA1Caenorhabditis elegans
I331LEVFKLATSCY1Drosophila melanogaster
I99RQIHVIDMDTI3Homo sapiens, Mus musculus, Rattus norvegicus
I99RDLSVIDMDTI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I99RNLEVIDMDRI1Arabidopsis thaliana
I99RTIEVIDMDTI1Caenorhabditis elegans
I99GNLHVIDMDTI1Drosophila melanogaster
I99RHIHVVDMDTI1Danio rerio
K124DVGRPKAEVAA3Danio rerio, Mus musculus, Rattus norvegicus
K124DIGRPKAEVAA1Homo sapiens
K124NIDEPKANVAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K124DVGKPKAEVAA1Arabidopsis thaliana
K124DVGKSKAEVAA1Caenorhabditis elegans
K124DIGASKAECAA1Drosophila melanogaster
K147VPHFNKIQDFN3Homo sapiens, Mus musculus, Rattus norvegicus
K147TPFYGKIQDKT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K147VPHFSRIEDKE1Arabidopsis thaliana
K147TAHNCRIEDKG1Caenorhabditis elegans
K147TPHFKKIQDFD1Drosophila melanogaster
K147VPHFKKIQDLD1Danio rerio
K361FEAERKENCPA3Homo sapiens, Mus musculus, Rattus norvegicus
K361FNLEKRSDCPV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K361TKFERDTECLV1Arabidopsis thaliana
K361VSMMKDDNCLT1Caenorhabditis elegans
K361YEAEKSENCLA1Drosophila melanogaster
K361FEAERKENCSA1Danio rerio
L166IIVCGLDSIIA3Homo sapiens, Mus musculus, Rattus norvegicus
L166LIICGLDSVEA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L166IIALGLDSIEA1Arabidopsis thaliana
L166IIICGLDSIPA1Caenorhabditis elegans
L166LVVCGLDSIVA1Drosophila melanogaster
L166IVVCGLDSVIA1Danio rerio
L214NARVILPGMTA4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
L214QARVIIPTITS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L214HARVILPGVTP1Arabidopsis thaliana
L214NARVIYPKFTA1Caenorhabditis elegans
L214NARVILPGFTA1Drosophila melanogaster
M101IHVIDMDTIDV3Homo sapiens, Mus musculus, Rattus norvegicus
M101LSVIDMDTIDI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M101LEVIDMDRIEV1Arabidopsis thaliana
M101IEVIDMDTIDV1Caenorhabditis elegans
M101LHVIDMDTIEL1Drosophila melanogaster
M101IHVVDMDTIDV1Danio rerio
M217VILPGMTACIE3Homo sapiens, Mus musculus, Rattus norvegicus
M217VIIPTITSCYE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M217VILPGVTPCFE1Arabidopsis thaliana
M217VIYPKFTACID1Caenorhabditis elegans
M217VILPGFTACIE1Drosophila melanogaster
M217VILPGMTACID1Danio rerio
N108TIDVSNLNRQF5Homo sapiens, Caenorhabditis elegans, Danio rerio, Mus musculus, Rattus norvegicus
N108TIDITNLNRQF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N108RIEVTNLNRQF1Arabidopsis thaliana
N108TIELSNLNRQF1Drosophila melanogaster
N146VVPHFNKIQDF3Homo sapiens, Mus musculus, Rattus norvegicus
N146VTPFYGKIQDK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N146IVPHFSRIEDK1Arabidopsis thaliana
N146VTAHNCRIEDK1Caenorhabditis elegans
N146VTPHFKKIQDF1Drosophila melanogaster
N146VVPHFKKIQDL1Danio rerio
P197PSSIVPLIDGG3Homo sapiens, Mus musculus, Rattus norvegicus
P197TGDLIPLVDGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P197RETIKPMVDGG1Arabidopsis thaliana
P197ENTIIPMIDGG1Caenorhabditis elegans
P197TSSIVPMIDGG1Drosophila melanogaster
P197PSSIIPLIDGG1Danio rerio
P54GPFTHPDFEPS3Homo sapiens, Mus musculus, Rattus norvegicus
P54GPFNLDAPENP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P54GNLVDPGFVPG1Arabidopsis thaliana
P54SAYKVPWFVPG1Caenorhabditis elegans
P54GPFCKDGFAAS1Drosophila melanogaster
P54GPFTHPDFEAS1Danio rerio
Q112SNLNRQFLFRP4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
Q112TNLNRQFLFNE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q112TNLNRQFLFRI1Arabidopsis thaliana
Q112SNLNRQFLFRE1Caenorhabditis elegans
Q112SNLNRQFLFRR1Drosophila melanogaster
Q149HFNKIQDFNDT3Homo sapiens, Mus musculus, Rattus norvegicus
Q149FYGKIQDKTIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q149HFSRIEDKEIE1Arabidopsis thaliana
Q149HNCRIEDKGQE1Caenorhabditis elegans
Q149HFKKIQDFDES1Drosophila melanogaster
Q149HFKKIQDLDET1Danio rerio
Q158DTFYRQFHIIV3Homo sapiens, Mus musculus, Rattus norvegicus
Q158IEFYKEFKLII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q158IEFYNDFNIIA1Arabidopsis thaliana
Q158QEFYRKFSIII1Caenorhabditis elegans
Q158ESFYQQFHLVV1Drosophila melanogaster
Q158ETFYRQFHIVV1Danio rerio
R111VSNLNRQFLFR5Homo sapiens, Caenorhabditis elegans, Danio rerio, Mus musculus, Rattus norvegicus
R111ITNLNRQFLFN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R111VTNLNRQFLFR1Arabidopsis thaliana
R111LSNLNRQFLFR1Drosophila melanogaster
R157NDTFYRQFHII3Homo sapiens, Mus musculus, Rattus norvegicus
R157TIEFYKEFKLI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R157EIEFYNDFNII1Arabidopsis thaliana
R157GQEFYRKFSII1Caenorhabditis elegans
R157DESFYQQFHLV1Drosophila melanogaster
R157DETFYRQFHIV1Danio rerio
S334FKIATSAYIPL3Homo sapiens, Mus musculus, Rattus norvegicus
S334LKILTESNPFL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S334LKIVSACSKTL1Arabidopsis thaliana
S334LKLATNIAKPI1Caenorhabditis elegans
S334FKLATSCYDSM1Drosophila melanogaster
S334FKIATSAYVPL1Danio rerio
S394LTNSASLQMKS3Homo sapiens, Mus musculus, Rattus norvegicus
S394YSK--SYNLQN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S394LEDHPKLLLSK1Arabidopsis thaliana
S394LSE--RFHLKH1Caenorhabditis elegans
S394LCDSPRFQLKS1Drosophila melanogaster
S394LTENASLQMKS1Danio rerio
S62EPSTESLQFLL3Homo sapiens, Mus musculus, Rattus norvegicus
S62ENPEETLKSAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S62VPGPGLRDDIR1Arabidopsis thaliana
S62VPGPENFEALQ1Caenorhabditis elegans
S62AASSENLEFLQ1Drosophila melanogaster
S62EASTESLQFLL1Danio rerio
T333VFKIATSAYIP3Homo sapiens, Mus musculus, Rattus norvegicus
T333ALKILTESNPF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T333TLKIVSACSKT1Arabidopsis thaliana
T333ALKLATNIAKP1Caenorhabditis elegans
T333VFKLATSCYDS1Drosophila melanogaster
T333VFKIATSAYVP1Danio rerio
W174IIARRWINGML3Homo sapiens, Mus musculus, Rattus norvegicus
W174VEARRWINSTL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W174IEARKYINGVA1Arabidopsis thaliana
W174IPARRWINGML1Caenorhabditis elegans
W174IVARRWINGML1Drosophila melanogaster
W174VIARRWMNGML1Danio rerio


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