mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for TRIM41

Gene summary

Basic gene Info.	Gene symbol	TRIM41
	Gene name	tripartite motif containing 41
	Synonyms	RINCK
	Cytomap	UCSC genome browser: 5q35.3
	Type of gene	protein-coding
	RefGenes	NM_033549.4, NM_201627.2,NR_045218.1,
	Description	E3 ubiquitin-protein ligase TRIM41RING finger-interacting protein with C kinaseRING-finger protein that interacts with C kinase
	Modification date	20141207
dbXrefs	MIM : 610530
	HGNC : HGNC
	Ensembl : ENSG00000146063
	HPRD : 15558
	Vega : OTTHUMG00000130965
Protein	UniProt: Q8WV44 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_TRIM41
	BioGPS: 90933
Pathway	NCI Pathway Interaction Database: TRIM41
	KEGG: TRIM41
	REACTOME: TRIM41
	Pathway Commons: TRIM41
Context	iHOP: TRIM41
	ligand binding site mutation search in PubMed: TRIM41
	UCL Cancer Institute: TRIM41
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

Top

Ligand binding site mutations for TRIM41

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
C227	P228L	COAD	1
C227	P228H	COAD	1
C238	E239K	COAD	1
H258	V260M	GBM	1
D241	V240I	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Top

Protein structure related information for TRIM41

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
C227	P228H	-1.0539737
D241	V240I	-1.0261023
C238	E239K	-0.97817352
H258	V260M	-0.66956578
C227	P228L	-0.49729809

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TRIM41 from PDB

Top

Differential gene expression and gene-gene network for TRIM41

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of TRIM41 and the right PPI network was created from samples without mutations in the LBS of TRIM41. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

Top

Phenotype information for TRIM41

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin