mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HGS
Gene summary
Basic gene Info.Gene symbolHGS
Gene namehepatocyte growth factor-regulated tyrosine kinase substrate
CytomapUCSC genome browser: 17q25
Type of geneprotein-coding
Descriptionhuman growth factor-regulated tyrosine kinase substrateprotein pp110
Modification date20141207
dbXrefs MIM : 604375
Ensembl : ENSG00000185359
HPRD : 05085
Vega : OTTHUMG00000178109
ProteinUniProt: O14964
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HGS
BioGPS: 9146
PathwayNCI Pathway Interaction Database: HGS
Pathway Commons: HGS
ContextiHOP: HGS
ligand binding site mutation search in PubMed: HGS
UCL Cancer Institute: HGS
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0046426negative regulation of JAK-STAT cascade12444102

Ligand binding site mutations for HGS
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for HGS
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HGS from PDB

Differential gene expression and gene-gene network for HGS
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HGS and the right PPI network was created from samples without mutations in the LBS of HGS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for HGS
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for HGS
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Nutraceutical|vet_approvedDB04272Citric AcidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HGS go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of HGS
Multiple alignments for O14964 in multiple species
LBSAA sequence# speciesSpecies
C166VDAEECHRCRV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C166ADGRVCHRCRV1Drosophila melanogaster
C169EECHRCRVQFG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C169RVCHRCRVEFT1Drosophila melanogaster
C190CGQIFCGKCSS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C190CGQVFCGQCTA1Drosophila melanogaster
C193IFCGKCSSKYS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C193VFCGQCTAKQC1Drosophila melanogaster
H180VMTRKHHCRAC2Homo sapiens, Bos taurus
H180VVTRKHHCRAC2Mus musculus, Rattus norvegicus
H180FTNRKHHCRNC1Drosophila melanogaster
H181MTRKHHCRACG2Homo sapiens, Bos taurus
H181VTRKHHCRACG2Mus musculus, Rattus norvegicus
H181TNRKHHCRNCG1Drosophila melanogaster
K179GVMTRKHHCRA2Homo sapiens, Bos taurus
K179GVVTRKHHCRA2Mus musculus, Rattus norvegicus
K179TFTNRKHHCRN1Drosophila melanogaster
R178FGVMTRKHHCR2Homo sapiens, Bos taurus
R178FGVVTRKHHCR2Mus musculus, Rattus norvegicus
R178FTFTNRKHHCR1Drosophila melanogaster
R183RKHHCRACGQI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R183RKHHCRNCGQV1Drosophila melanogaster
W160ERAPDWVDAEE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W160DTAPNWADGRV1Drosophila melanogaster

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