mutLBSgeneDB |
Gene summary for ZMYM5 |
Gene summary |
Basic gene Info. | Gene symbol | ZMYM5 |
Gene name | zinc finger, MYM-type 5 | |
Synonyms | HSPC050|MYM|ZNF198L1|ZNF237 | |
Cytomap | UCSC genome browser: 13q12 | |
Type of gene | protein-coding | |
RefGenes | NM_014242.1, NM_001039649.2,NM_001039650.2,NM_001142684.1, | |
Description | zinc finger MYM-type protein 5zinc finger protein 198-like 1zinc finger protein 237 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000132950 | ||
Vega : OTTHUMG00000016504 | ||
Protein | UniProt: Q9UJ78 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZMYM5 | |
BioGPS: 9205 | ||
Pathway | NCI Pathway Interaction Database: ZMYM5 | |
KEGG: ZMYM5 | ||
REACTOME: ZMYM5 | ||
Pathway Commons: ZMYM5 | ||
Context | iHOP: ZMYM5 | |
ligand binding site mutation search in PubMed: ZMYM5 | ||
UCL Cancer Institute: ZMYM5 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for ZMYM5 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | C247 | K248E | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for ZMYM5 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C247 | K248E | -0.48620707 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ZMYM5 from PDB |
Top |
Differential gene expression and gene-gene network for ZMYM5 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for ZMYM5 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0032460 | Polycystic Ovary Syndrome | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for ZMYM5 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ZMYM5 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of ZMYM5 |
Multiple alignments for Q9UJ78 in multiple species |
LBS | AA sequence | # species | Species | C244 | PAKITCANCKK | 1 | Homo sapiens | C244 | PVKVTCANCKK | 1 | Mus musculus | C244 | AAKITCANCKK | 1 | Bos taurus | C247 | ITCANCKKPLQ | 2 | Homo sapiens, Bos taurus | C247 | VTCANCKKPLQ | 1 | Mus musculus | C268 | SAHLFCSTTCL | 3 | Homo sapiens, Mus musculus, Bos taurus | C272 | FCSTTCLSSFS | 3 | Homo sapiens, Mus musculus, Bos taurus |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |