mutLBSgeneDB |
Gene summary for ZMYM5 |
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Basic gene Info. | Gene symbol | ZMYM5 |
Gene name | zinc finger, MYM-type 5 | |
Synonyms | HSPC050|MYM|ZNF198L1|ZNF237 | |
Cytomap | UCSC genome browser: 13q12 | |
Type of gene | protein-coding | |
RefGenes | NM_014242.1, NM_001039649.2,NM_001039650.2,NM_001142684.1, | |
Description | zinc finger MYM-type protein 5zinc finger protein 198-like 1zinc finger protein 237 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000132950 | ||
Vega : OTTHUMG00000016504 | ||
Protein | UniProt: Q9UJ78 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZMYM5 | |
BioGPS: 9205 | ||
Pathway | NCI Pathway Interaction Database: ZMYM5 | |
KEGG: ZMYM5 | ||
REACTOME: ZMYM5 | ||
Pathway Commons: ZMYM5 | ||
Context | iHOP: ZMYM5 | |
ligand binding site mutation search in PubMed: ZMYM5 | ||
UCL Cancer Institute: ZMYM5 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ZMYM5 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | C247 | K248E | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ZMYM5 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C247 | K248E | -0.48620707 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for ZMYM5 |
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Phenotype information for ZMYM5 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0032460 | Polycystic Ovary Syndrome | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ZMYM5 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of ZMYM5 |
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LBS | AA sequence | # species | Species | C244 | PAKITCANCKK | 1 | Homo sapiens | C244 | PVKVTCANCKK | 1 | Mus musculus | C244 | AAKITCANCKK | 1 | Bos taurus | C247 | ITCANCKKPLQ | 2 | Homo sapiens, Bos taurus | C247 | VTCANCKKPLQ | 1 | Mus musculus | C268 | SAHLFCSTTCL | 3 | Homo sapiens, Mus musculus, Bos taurus | C272 | FCSTTCLSSFS | 3 | Homo sapiens, Mus musculus, Bos taurus |
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