mutLBSgeneDB |
Gene summary for RAB11B |
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Basic gene Info. | Gene symbol | RAB11B |
Gene name | RAB11B, member RAS oncogene family | |
Synonyms | H-YPT3 | |
Cytomap | UCSC genome browser: 19p13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_004218.3, | |
Description | GTP-binding protein YPT3RAB11B, member of RAS oncogene familyras-related protein Rab-11B | |
Modification date | 20141207 | |
dbXrefs | MIM : 604198 | |
HGNC : HGNC | ||
Ensembl : ENSG00000185236 | ||
HPRD : 05009 | ||
Vega : OTTHUMG00000182278 | ||
Protein | UniProt: Q15907 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RAB11B | |
BioGPS: 9230 | ||
Pathway | NCI Pathway Interaction Database: RAB11B | |
KEGG: RAB11B | ||
REACTOME: RAB11B | ||
Pathway Commons: RAB11B | ||
Context | iHOP: RAB11B | |
ligand binding site mutation search in PubMed: RAB11B | ||
UCL Cancer Institute: RAB11B | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0006184 | GTP catabolic process | 16545962 | GO:0071468 | cellular response to acidic pH | 20717956 |
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Ligand binding site mutations for RAB11B |
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LBS | AAchange of nsSNV | Cancer type | # samples | K41,E39 | S40I | STAD | 1 | S25 | S25N | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for RAB11B |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S25 | S25N | 0.087304892 | K41 | S40I | -0.95396762 | E39 | S40I | -0.95396762 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for RAB11B |
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Phenotype information for RAB11B |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0019693 | HIV Infections | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for RAB11B |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GDP | GUANOSINE-5'-DIPHOSPHATE | 2f9l | A | S25 | MG | MAGNESIUM(2+) | 2f9m | A | S25 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 2f9m | A | S25 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4ojk | B | S25 E39 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4ojk | A | S25 E39 K41 |
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Conservation information for LBS of RAB11B |
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LBS | AA sequence | # species | Species | A155 | FIETSALDSTN | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | A155 | FTETSALNSDN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A155 | FIETSALEALN | 1 | Arabidopsis thaliana | D127 | VGNKSDLRHLR | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | D127 | IGNKSDLAHLR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D127 | IGNKTDLKHLR | 1 | Arabidopsis thaliana | D19 | VVLIGDSGVGK | 5 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | D19 | IVLIGDSGVGK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E39 | NEFNLESKSTI | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | E39 | DEFNIESKSTI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E39 | NEFCLESKSTI | 1 | Arabidopsis thaliana | F36 | FTRNEFNLESK | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | F36 | FTTDEFNIESK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F36 | FTRNEFCLESK | 1 | Arabidopsis thaliana | G21 | LIGDSGVGKSN | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | G23 | GDSGVGKSNLL | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | K125 | MLVGNKSDLRH | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | K125 | GLIGNKSDLAH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K125 | MLIGNKTDLKH | 1 | Arabidopsis thaliana | K24 | DSGVGKSNLLS | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | K41 | FNLESKSTIGV | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | K41 | FNIESKSTIGV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K41 | FCLESKSTIGV | 1 | Arabidopsis thaliana | L128 | GNKSDLRHLRA | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | L128 | GNKSDLAHLRA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L128 | GNKTDLKHLRA | 1 | Arabidopsis thaliana | L156 | IETSALDSTNV | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | L156 | TETSALNSDNV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L156 | IETSALEALNV | 1 | Arabidopsis thaliana | L38 | RNEFNLESKST | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | L38 | TDEFNIESKST | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L38 | RNEFCLESKST | 1 | Arabidopsis thaliana | N124 | IMLVGNKSDLR | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | N124 | VGLIGNKSDLA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N124 | IMLIGNKTDLK | 1 | Arabidopsis thaliana | N26 | GVGKSNLLSRF | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | N37 | TRNEFNLESKS | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | N37 | TTDEFNIESKS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N37 | TRNEFCLESKS | 1 | Arabidopsis thaliana | S154 | SFIETSALDST | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | S154 | LFTETSALNSD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S154 | SFIETSALEAL | 1 | Arabidopsis thaliana | S25 | SGVGKSNLLSR | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | V22 | IGDSGVGKSNL | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana |
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