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mutLBSgeneDB |
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| Gene summary for RAB11B |
 Gene summary |
| Basic gene Info. | Gene symbol | RAB11B |
| Gene name | RAB11B, member RAS oncogene family | |
| Synonyms | H-YPT3 | |
| Cytomap | UCSC genome browser: 19p13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004218.3, | |
| Description | GTP-binding protein YPT3RAB11B, member of RAS oncogene familyras-related protein Rab-11B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604198 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000185236 | ||
| HPRD : 05009 | ||
| Vega : OTTHUMG00000182278 | ||
| Protein | UniProt: Q15907 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RAB11B | |
| BioGPS: 9230 | ||
| Pathway | NCI Pathway Interaction Database: RAB11B | |
| KEGG: RAB11B | ||
| REACTOME: RAB11B | ||
| Pathway Commons: RAB11B | ||
| Context | iHOP: RAB11B | |
| ligand binding site mutation search in PubMed: RAB11B | ||
| UCL Cancer Institute: RAB11B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006184 | GTP catabolic process | 16545962 | GO:0071468 | cellular response to acidic pH | 20717956 |
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| Ligand binding site mutations for RAB11B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K41,E39 | S40I | STAD | 1 | S25 | S25N | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RAB11B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S25 | S25N | 0.087304892 | K41 | S40I | -0.95396762 | E39 | S40I | -0.95396762 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RAB11B from PDB |
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| Differential gene expression and gene-gene network for RAB11B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RAB11B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0019693 | HIV Infections | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RAB11B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RAB11B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GDP | GUANOSINE-5'-DIPHOSPHATE | 2f9l | A | S25 | MG | MAGNESIUM(2+) | 2f9m | A | S25 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 2f9m | A | S25 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4ojk | B | S25 E39 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4ojk | A | S25 E39 K41 |
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| Conservation information for LBS of RAB11B |
| Multiple alignments for Q15907 in multiple species |
| LBS | AA sequence | # species | Species | A155 | FIETSALDSTN | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | A155 | FTETSALNSDN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A155 | FIETSALEALN | 1 | Arabidopsis thaliana | D127 | VGNKSDLRHLR | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | D127 | IGNKSDLAHLR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D127 | IGNKTDLKHLR | 1 | Arabidopsis thaliana | D19 | VVLIGDSGVGK | 5 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | D19 | IVLIGDSGVGK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E39 | NEFNLESKSTI | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | E39 | DEFNIESKSTI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E39 | NEFCLESKSTI | 1 | Arabidopsis thaliana | F36 | FTRNEFNLESK | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | F36 | FTTDEFNIESK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F36 | FTRNEFCLESK | 1 | Arabidopsis thaliana | G21 | LIGDSGVGKSN | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | G23 | GDSGVGKSNLL | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | K125 | MLVGNKSDLRH | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | K125 | GLIGNKSDLAH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K125 | MLIGNKTDLKH | 1 | Arabidopsis thaliana | K24 | DSGVGKSNLLS | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | K41 | FNLESKSTIGV | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | K41 | FNIESKSTIGV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K41 | FCLESKSTIGV | 1 | Arabidopsis thaliana | L128 | GNKSDLRHLRA | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | L128 | GNKSDLAHLRA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L128 | GNKTDLKHLRA | 1 | Arabidopsis thaliana | L156 | IETSALDSTNV | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | L156 | TETSALNSDNV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L156 | IETSALEALNV | 1 | Arabidopsis thaliana | L38 | RNEFNLESKST | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | L38 | TDEFNIESKST | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L38 | RNEFCLESKST | 1 | Arabidopsis thaliana | N124 | IMLVGNKSDLR | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | N124 | VGLIGNKSDLA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N124 | IMLIGNKTDLK | 1 | Arabidopsis thaliana | N26 | GVGKSNLLSRF | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | N37 | TRNEFNLESKS | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | N37 | TTDEFNIESKS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N37 | TRNEFCLESKS | 1 | Arabidopsis thaliana | S154 | SFIETSALDST | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | S154 | LFTETSALNSD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S154 | SFIETSALEAL | 1 | Arabidopsis thaliana | S25 | SGVGKSNLLSR | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana | V22 | IGDSGVGKSNL | 6 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Rattus norvegicus, Mus musculus, Arabidopsis thaliana |
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