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mutLBSgeneDB |
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| Gene summary for STRADA |
 Gene summary |
| Basic gene Info. | Gene symbol | STRADA |
| Gene name | STE20-related kinase adaptor alpha | |
| Synonyms | LYK5|NY-BR-96|PMSE|STRAD|Stlk | |
| Cytomap | UCSC genome browser: 17q23.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001003786.2, NM_001003787.2,NM_001003788.2,NM_001165969.1,NM_001165970.1, NM_153335.5, | |
| Description | STE20-like pseudokinaseSTE20-related kinase adapter protein alphaSTRAD alphaprotein kinase LYK5serologically defined breast cancer antigen NY-BR-96 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608626 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000266173 | ||
| HPRD : 14332 | ||
| Vega : OTTHUMG00000178908 | ||
| Protein | UniProt: Q7RTN6 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_STRADA | |
| BioGPS: 92335 | ||
| Pathway | NCI Pathway Interaction Database: STRADA | |
| KEGG: STRADA | ||
| REACTOME: STRADA | ||
| Pathway Commons: STRADA | ||
| Context | iHOP: STRADA | |
| ligand binding site mutation search in PubMed: STRADA | ||
| UCL Cancer Institute: STRADA | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 12805220 | GO:0006611 | protein export from nucleus | 12805220 | GO:0032147 | activation of protein kinase activity | 12805220 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 19892943 |
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| Ligand binding site mutations for STRADA |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D157 | D157H | BLCA | 1 | K77 | K77R | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for STRADA |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K77 | K77R | -0.64764547 | D157 | D157H | -0.42376297 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for STRADA from PDB |
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| Differential gene expression and gene-gene network for STRADA |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for STRADA |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0025149 | Medulloblastoma | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for STRADA |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of STRADA go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ANP | AMP-PNP | 2wtk | B | K77 D157 | ANP | AMP-PNP | 2wtk | E | K77 D157 | ATP | ATP | 3gni | B | K77 D157 |
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| Conservation information for LBS of STRADA |
| Multiple alignments for Q7RTN6 in multiple species |
| LBS | AA sequence | # species | Species | D157 | YGSAKDLICTH | 2 | Homo sapiens, Bos taurus | D157 | YGSAKDLIGTH | 2 | Mus musculus, Rattus norvegicus | D157 | LGSLFDIVFEY | 1 | Caenorhabditis elegans | D157 | FGNCEVLLKNV | 1 | Drosophila melanogaster | F415 | DHSGIFGLVTN | 3 | Homo sapiens, Mus musculus, Bos taurus | F415 | QEP-------- | 1 | Caenorhabditis elegans | F415 | ----IFSDARG | 1 | Drosophila melanogaster | F415 | DHSGILGLVTN | 1 | Rattus norvegicus | F79 | VIGKGFEDLMT | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | F79 | YMGTCNGGQIY | 1 | Caenorhabditis elegans | F79 | ILKNGMIGTVY | 1 | Drosophila melanogaster | F79 | IIGKGFEDLMT | 1 | Mus musculus | G76 | LLTVIGKGFED | 2 | Homo sapiens, Bos taurus | G76 | CVRYMGTCNGG | 1 | Caenorhabditis elegans | G76 | LLEILKNGMIG | 1 | Drosophila melanogaster | G76 | LLTIIGKGFED | 1 | Mus musculus | G76 | LLSVIGKGFED | 1 | Rattus norvegicus | G78 | TVIGKGFEDLM | 2 | Homo sapiens, Bos taurus | G78 | RYMGTCNGGQI | 1 | Caenorhabditis elegans | G78 | EILKNGMIGTV | 1 | Drosophila melanogaster | G78 | TIIGKGFEDLM | 1 | Mus musculus | G78 | SVIGKGFEDLM | 1 | Rattus norvegicus | H200 | SVKASHILIST | 2 | Mus musculus, Rattus norvegicus | H200 | SVKASHILISV | 1 | Homo sapiens | H200 | DLKPKHILIDS | 1 | Caenorhabditis elegans | H200 | SVRAKHILLSP | 1 | Drosophila melanogaster | H200 | SVKASHVLISA | 1 | Bos taurus | I75 | ELLTVIGKGFE | 2 | Homo sapiens, Bos taurus | I75 | DCVRYMGTCNG | 1 | Caenorhabditis elegans | I75 | KLLEILKNGMI | 1 | Drosophila melanogaster | I75 | ELLTIIGKGFE | 1 | Mus musculus | I75 | ELLSVIGKGFE | 1 | Rattus norvegicus | K197 | VHRSVKASHIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K197 | IHRDLKPKHIL | 1 | Caenorhabditis elegans | K197 | VHGSVRAKHIL | 1 | Drosophila melanogaster | K197 | VHRSVKASHVL | 1 | Bos taurus | K239 | PKYSIKVLPWL | 3 | Mus musculus, Rattus norvegicus, Bos taurus | K239 | PKYSVKVLPWL | 1 | Homo sapiens | K239 | DAHLQNQLYYL | 1 | Caenorhabditis elegans | K239 | TVGIEKELYWT | 1 | Drosophila melanogaster | K77 | LTVIGKGFEDL | 2 | Homo sapiens, Bos taurus | K77 | VRYMGTCNGGQ | 1 | Caenorhabditis elegans | K77 | LEILKNGMIGT | 1 | Drosophila melanogaster | K77 | LTIIGKGFEDL | 1 | Mus musculus | K77 | LSVIGKGFEDL | 1 | Rattus norvegicus | L202 | KASHILISTDG | 2 | Mus musculus, Rattus norvegicus | L202 | KASHILISVDG | 1 | Homo sapiens | L202 | KPKHILIDSSG | 1 | Caenorhabditis elegans | L202 | RAKHILLSPR- | 1 | Drosophila melanogaster | L202 | KASHVLISADG | 1 | Bos taurus | M150 | VVTSFMAYGSA | 3 | Homo sapiens, Mus musculus, Bos taurus | M150 | QITPAMNLGSL | 1 | Caenorhabditis elegans | M150 | LTYKFMCFGNC | 1 | Drosophila melanogaster | M150 | AVTSFMAYGSA | 1 | Rattus norvegicus | M83 | GFEDLMTVNLA | 3 | Homo sapiens, Mus musculus, Bos taurus | M83 | CNGGQIYLGRE | 1 | Caenorhabditis elegans | M83 | GMIGTVY---K | 1 | Drosophila melanogaster | M83 | GFEDLMTVN-S | 1 | Rattus norvegicus | R100 | EYVTVRRINLE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R100 | DYVAIKKFAID | 1 | Caenorhabditis elegans | R100 | KCLAVKKVSMD | 1 | Drosophila melanogaster | R215 | YLSGLRSNLSM | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R215 | KLSGFRF---M | 1 | Caenorhabditis elegans | R215 | VLSNFSYCQSF | 1 | Drosophila melanogaster | S148 | LWVVTSFMAYG | 3 | Homo sapiens, Mus musculus, Bos taurus | S148 | IYQITPAMNLG | 1 | Caenorhabditis elegans | S148 | VYLTYKFMCFG | 1 | Drosophila melanogaster | S148 | LWAVTSFMAYG | 1 | Rattus norvegicus | S154 | FMAYGSAKDLI | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S154 | AMNLGSLFDIV | 1 | Caenorhabditis elegans | S154 | FMCFGNCEVLL | 1 | Drosophila melanogaster | S199 | RSVKASHILIS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S199 | RDLKPKHILID | 1 | Caenorhabditis elegans | S199 | GSVRAKHILLS | 1 | Drosophila melanogaster | S199 | RSVKASHVLIS | 1 | Bos taurus | T147 | ELWVVTSFMAY | 3 | Homo sapiens, Mus musculus, Bos taurus | T147 | SIYQITPAMNL | 1 | Caenorhabditis elegans | T147 | YVYLTYKFMCF | 1 | Drosophila melanogaster | T147 | ELWAVTSFMAY | 1 | Rattus norvegicus | T98 | TGEYVTVRRIN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T98 | LKDYVAIKKFA | 1 | Caenorhabditis elegans | T98 | NNKCLAVKKVS | 1 | Drosophila melanogaster | V85 | EDLMTVNLARY | 3 | Homo sapiens, Mus musculus, Bos taurus | V85 | GGQIYLGRER- | 1 | Caenorhabditis elegans | V85 | IGTVY---KAE | 1 | Drosophila melanogaster | V85 | EDLMTVN-SRY | 1 | Rattus norvegicus |
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