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mutLBSgeneDB |
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| Gene summary for METTL18 |
 Gene summary |
| Basic gene Info. | Gene symbol | METTL18 |
| Gene name | methyltransferase like 18 | |
| Synonyms | AsTP2|C1orf156|HPM1 | |
| Cytomap | UCSC genome browser: 1q24.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_033418.2, | |
| Description | arsenic-transactivated protein 2histidine protein methyltransferase 1 homologmethyltransferase-like protein 18 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 615255 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000171806 | ||
| HPRD : 14713 | ||
| Vega : OTTHUMG00000035813 | ||
| Protein | UniProt: O95568 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_METTL18 | |
| BioGPS: 92342 | ||
| Pathway | NCI Pathway Interaction Database: METTL18 | |
| KEGG: METTL18 | ||
| REACTOME: METTL18 | ||
| Pathway Commons: METTL18 | ||
| Context | iHOP: METTL18 | |
| ligand binding site mutation search in PubMed: METTL18 | ||
| UCL Cancer Institute: METTL18 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for METTL18 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S293 | L291I | COAD | 1 | W270 | W270C | LUAD | 1 | P78 | P78L | SKCM | 1 | W270 | E272G | STAD | 1 | Y218 | N219S | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for METTL18 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y218 | N219S | -1.2403717 | W270 | E272G | -1.2293938 | S293 | L291I | -0.85896394 | W270 | W270C | -0.6443452 | P78 | P78L | -0.3786403 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for METTL18 from PDB |
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| Differential gene expression and gene-gene network for METTL18 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for METTL18 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0017661 | Glomerulonephritis, IGA | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for METTL18 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of METTL18 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | SAM | S-ADENOSYL-L-METHIONINE | 4rfq | A | P78 Y218 W270 S293 |
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| Conservation information for LBS of METTL18 |
| Multiple alignments for O95568 in multiple species |
| LBS | AA sequence | # species | Species | C196 | VLDLGCGSGLL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D217 | EVHFQDYNGLV | 2 | Mus musculus, Rattus norvegicus | D217 | EIHFQDYNSMV | 1 | Homo sapiens | D217 | EIHFQDYNSVV | 1 | Bos taurus | E269 | RFFSGEWSEFC | 2 | Homo sapiens, Bos taurus | E269 | RLFSGEWAEFC | 2 | Mus musculus, Rattus norvegicus | E89 | SSRNLEPHGKQ | 1 | Homo sapiens | E89 | RSDDPEACKHQ | 1 | Mus musculus | E89 | RSGVPEACEKQ | 1 | Rattus norvegicus | E89 | SSSNLEPHEEK | 1 | Bos taurus | G195 | KVLDLGCGSGL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G197 | LDLGCGSGLLG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G268 | CRFFSGEWSEF | 2 | Homo sapiens, Bos taurus | G268 | CRLFSGEWAEF | 2 | Mus musculus, Rattus norvegicus | I168 | EGGLKIWECTF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | P78 | QDTDSPLSAAS | 1 | Homo sapiens | P78 | EDTGSPPPIAD | 1 | Mus musculus | P78 | EDTDSPPSTAD | 1 | Rattus norvegicus | P78 | QDPDSSFGAAN | 1 | Bos taurus | P90 | SRNLEPHGKQP | 1 | Homo sapiens | P90 | SDDPEACKHQP | 1 | Mus musculus | P90 | SGVPEACEKQP | 1 | Rattus norvegicus | P90 | SSNLEPHEEKP | 1 | Bos taurus | Q216 | REVHFQDYNGL | 2 | Mus musculus, Rattus norvegicus | Q216 | KEIHFQDYNSM | 1 | Homo sapiens | Q216 | KEIHFQDYNSV | 1 | Bos taurus | S293 | DLILTSETIYN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T172 | KIWECTFDLLA | 2 | Homo sapiens, Bos taurus | T172 | KIWECTFDLLT | 1 | Mus musculus | T172 | KIWECTFDLMT | 1 | Rattus norvegicus | T295 | ILTSETIYNPD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | W169 | GGLKIWECTFD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | W270 | FFSGEWSEFCK | 2 | Homo sapiens, Bos taurus | W270 | LFSGEWAEFCK | 2 | Mus musculus, Rattus norvegicus | Y218 | VHFQDYNGLVI | 2 | Mus musculus, Rattus norvegicus | Y218 | IHFQDYNSMVI | 1 | Homo sapiens | Y218 | IHFQDYNSVVI | 1 | Bos taurus | Y301 | IYNPDYYSTLH | 2 | Mus musculus, Rattus norvegicus | Y301 | IYNPDYYSNLH | 1 | Homo sapiens | Y301 | IYNPDYYVPLH | 1 | Bos taurus |
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