mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RPS6KA5
Gene summary
Basic gene Info.Gene symbolRPS6KA5
Gene nameribosomal protein S6 kinase, 90kDa, polypeptide 5
CytomapUCSC genome browser: 14q31-q32.1
Type of geneprotein-coding
Description90 kDa ribosomal protein S6 kinase 5RSK-like protein kinaseRSKLS6K-alpha-5nuclear mitogen- and stress-activated protein kinase 1ribosomal protein S6 kinase alpha-5
Modification date20141207
dbXrefs MIM : 603607
Ensembl : ENSG00000100784
HPRD : 06789
Vega : OTTHUMG00000171055
ProteinUniProt: O75582
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RPS6KA5
BioGPS: 9252
PathwayNCI Pathway Interaction Database: RPS6KA5
Pathway Commons: RPS6KA5
ContextiHOP: RPS6KA5
ligand binding site mutation search in PubMed: RPS6KA5
UCL Cancer Institute: RPS6KA5
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006355regulation of transcription, DNA-templated9687510
GO:0006468protein phosphorylation9687510
GO:0016572histone phosphorylation9873047
GO:0035556intracellular signal transduction9687510
GO:0043990histone H2A-S1 phosphorylation15010469
GO:0045892negative regulation of transcription, DNA-templated15010469

Ligand binding site mutations for RPS6KA5

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for RPS6KA5
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RPS6KA5 from PDB

Differential gene expression and gene-gene network for RPS6KA5
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RPS6KA5 and the right PPI network was created from samples without mutations in the LBS of RPS6KA5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for RPS6KA5
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0236736Cocaine-Related Disorders1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for RPS6KA5
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RPS6KA5 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ANPAMP-PNP3kn5AA453 E548 I564
ANPAMP-PNP3kn5BA453 E548 I564

Conservation information for LBS of RPS6KA5
Multiple alignments for O75582 in multiple species
LBSAA sequence# speciesSpecies
A453SNQAFAVKIIS1Homo sapiens
A453TDLVFLAKIIP1Drosophila melanogaster
A453DGAQFAVKIVS1Caenorhabditis elegans
A453TSQEYAVKIIS1Gallus gallus
A453TNQAFAVKIIS1Mus musculus
E434KP-LGEGSFSI3Homo sapiens, Gallus gallus, Mus musculus
E434RT--SNGAYGT1Drosophila melanogaster
E434AGLLGKGAFSV1Caenorhabditis elegans
E499TFLVMELLNGG2Homo sapiens, Mus musculus
E499TWIVMEYLSGP1Drosophila melanogaster
E499FYLVMEILTGN1Caenorhabditis elegans
E499TFLVMELLKGG1Gallus gallus
E505LLNGGELFERI2Homo sapiens, Mus musculus
E505YLSGPELTASI1Drosophila melanogaster
E505ILTGNELLERI1Caenorhabditis elegans
E505LLKGGELLERI1Gallus gallus
E548RDLKPENLLFT3Homo sapiens, Gallus gallus, Mus musculus
E548GDLKPENIMFE1Drosophila melanogaster
E548RDLKPENILFE1Caenorhabditis elegans
G433DKP-LGEGSFS2Homo sapiens, Mus musculus
G433TRT--SNGAYG1Drosophila melanogaster
G433DAGLLGKGAFS1Caenorhabditis elegans
G433EKP-LGEGSFS1Gallus gallus
I564LEIKIIDFGFA1Homo sapiens
I564T-VKLIDFGSA1Drosophila melanogaster
I564ARLRLVDFGFA1Caenorhabditis elegans
I564SEIKIIDFGFA1Gallus gallus
I564LEIKVIDFGFA1Mus musculus
K716---CVKATFHA2Homo sapiens, Mus musculus
K716PAFEVQADFYG1Drosophila melanogaster
K716-----NETLRA1Caenorhabditis elegans
K716---YVKATFHA1Gallus gallus
L432KDKP-LGEGSF2Homo sapiens, Mus musculus
L432GTRT--SNGAY1Drosophila melanogaster
L432SDAGLLGKGAF1Caenorhabditis elegans
L432KEKP-LGEGSF1Gallus gallus
L500FLVMELLNGGE2Homo sapiens, Mus musculus
L500WIVMEYLSGPE1Drosophila melanogaster
L500YLVMEILTGNE1Caenorhabditis elegans
L500FLVMELLKGGE1Gallus gallus
L501LVMELLNGGEL2Homo sapiens, Mus musculus
L501IVMEYLSGPEL1Drosophila melanogaster
L501LVMEILTGNEL1Caenorhabditis elegans
L501LVMELLKGGEL1Gallus gallus

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