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mutLBSgeneDB |
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| Gene summary for RPS6KA5 |
 Gene summary |
| Basic gene Info. | Gene symbol | RPS6KA5 |
| Gene name | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | |
| Synonyms | MSK1|MSPK1|RLPK | |
| Cytomap | UCSC genome browser: 14q31-q32.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004755.2, NM_182398.1, | |
| Description | 90 kDa ribosomal protein S6 kinase 5RSK-like protein kinaseRSKLS6K-alpha-5nuclear mitogen- and stress-activated protein kinase 1ribosomal protein S6 kinase alpha-5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603607 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000100784 | ||
| HPRD : 06789 | ||
| Vega : OTTHUMG00000171055 | ||
| Protein | UniProt: O75582 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RPS6KA5 | |
| BioGPS: 9252 | ||
| Pathway | NCI Pathway Interaction Database: RPS6KA5 | |
| KEGG: RPS6KA5 | ||
| REACTOME: RPS6KA5 | ||
| Pathway Commons: RPS6KA5 | ||
| Context | iHOP: RPS6KA5 | |
| ligand binding site mutation search in PubMed: RPS6KA5 | ||
| UCL Cancer Institute: RPS6KA5 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006355 | regulation of transcription, DNA-templated | 9687510 | GO:0006468 | protein phosphorylation | 9687510 | GO:0016572 | histone phosphorylation | 9873047 | GO:0035556 | intracellular signal transduction | 9687510 | GO:0043990 | histone H2A-S1 phosphorylation | 15010469 | GO:0045892 | negative regulation of transcription, DNA-templated | 15010469 |
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| Ligand binding site mutations for RPS6KA5 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I564 | I563V | LUAD | 1 | E548 | P547H | UCEC | 1 | A453 | A451D | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RPS6KA5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | A453 | A451D | -1.1822485 | I564 | I563V | -1.1229561 | E548 | P547H | -0.81704345 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RPS6KA5 from PDB |
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| Differential gene expression and gene-gene network for RPS6KA5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RPS6KA5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0236736 | Cocaine-Related Disorders | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RPS6KA5 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RPS6KA5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ANP | AMP-PNP | 3kn5 | A | A453 E548 I564 | ANP | AMP-PNP | 3kn5 | B | A453 E548 I564 |
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| Conservation information for LBS of RPS6KA5 |
| Multiple alignments for O75582 in multiple species |
| LBS | AA sequence | # species | Species | A453 | SNQAFAVKIIS | 1 | Homo sapiens | A453 | TDLVFLAKIIP | 1 | Drosophila melanogaster | A453 | DGAQFAVKIVS | 1 | Caenorhabditis elegans | A453 | TSQEYAVKIIS | 1 | Gallus gallus | A453 | TNQAFAVKIIS | 1 | Mus musculus | E434 | KP-LGEGSFSI | 3 | Homo sapiens, Gallus gallus, Mus musculus | E434 | RT--SNGAYGT | 1 | Drosophila melanogaster | E434 | AGLLGKGAFSV | 1 | Caenorhabditis elegans | E499 | TFLVMELLNGG | 2 | Homo sapiens, Mus musculus | E499 | TWIVMEYLSGP | 1 | Drosophila melanogaster | E499 | FYLVMEILTGN | 1 | Caenorhabditis elegans | E499 | TFLVMELLKGG | 1 | Gallus gallus | E505 | LLNGGELFERI | 2 | Homo sapiens, Mus musculus | E505 | YLSGPELTASI | 1 | Drosophila melanogaster | E505 | ILTGNELLERI | 1 | Caenorhabditis elegans | E505 | LLKGGELLERI | 1 | Gallus gallus | E548 | RDLKPENLLFT | 3 | Homo sapiens, Gallus gallus, Mus musculus | E548 | GDLKPENIMFE | 1 | Drosophila melanogaster | E548 | RDLKPENILFE | 1 | Caenorhabditis elegans | G433 | DKP-LGEGSFS | 2 | Homo sapiens, Mus musculus | G433 | TRT--SNGAYG | 1 | Drosophila melanogaster | G433 | DAGLLGKGAFS | 1 | Caenorhabditis elegans | G433 | EKP-LGEGSFS | 1 | Gallus gallus | I564 | LEIKIIDFGFA | 1 | Homo sapiens | I564 | T-VKLIDFGSA | 1 | Drosophila melanogaster | I564 | ARLRLVDFGFA | 1 | Caenorhabditis elegans | I564 | SEIKIIDFGFA | 1 | Gallus gallus | I564 | LEIKVIDFGFA | 1 | Mus musculus | K716 | ---CVKATFHA | 2 | Homo sapiens, Mus musculus | K716 | PAFEVQADFYG | 1 | Drosophila melanogaster | K716 | -----NETLRA | 1 | Caenorhabditis elegans | K716 | ---YVKATFHA | 1 | Gallus gallus | L432 | KDKP-LGEGSF | 2 | Homo sapiens, Mus musculus | L432 | GTRT--SNGAY | 1 | Drosophila melanogaster | L432 | SDAGLLGKGAF | 1 | Caenorhabditis elegans | L432 | KEKP-LGEGSF | 1 | Gallus gallus | L500 | FLVMELLNGGE | 2 | Homo sapiens, Mus musculus | L500 | WIVMEYLSGPE | 1 | Drosophila melanogaster | L500 | YLVMEILTGNE | 1 | Caenorhabditis elegans | L500 | FLVMELLKGGE | 1 | Gallus gallus | L501 | LVMELLNGGEL | 2 | Homo sapiens, Mus musculus | L501 | IVMEYLSGPEL | 1 | Drosophila melanogaster | L501 | LVMEILTGNEL | 1 | Caenorhabditis elegans | L501 | LVMELLKGGEL | 1 | Gallus gallus |
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