mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAPKAPK2
Gene summary
Basic gene Info.Gene symbolMAPKAPK2
Gene namemitogen-activated protein kinase-activated protein kinase 2
SynonymsMAPKAP-K2|MK-2|MK2
CytomapUCSC genome browser: 1q32
Type of geneprotein-coding
RefGenesNM_004759.4,
NM_032960.3,
DescriptionMAP kinase-activated protein kinase 2MAPK-activated protein kinase 2MAPKAP kinase 2
Modification date20141207
dbXrefs MIM : 602006
HGNC : HGNC
Ensembl : ENSG00000162889
HPRD : 11882
Vega : OTTHUMG00000036342
ProteinUniProt: P49137
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAPKAPK2
BioGPS: 9261
PathwayNCI Pathway Interaction Database: MAPKAPK2
KEGG: MAPKAPK2
REACTOME: MAPKAPK2
Pathway Commons: MAPKAPK2
ContextiHOP: MAPKAPK2
ligand binding site mutation search in PubMed: MAPKAPK2
UCL Cancer Institute: MAPKAPK2
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for MAPKAPK2.1. Kervinen, J., Ma, H., Bayoumy, S., Schubert, C., Milligan, C., Lewandowski, F., ... & Harris, C. A. (2006). Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity. Archives of biochemistry and biophysics, 449(1), 47-56. 16620770

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006950response to stress15014438
GO:0018105peptidyl-serine phosphorylation15850461
GO:0032680regulation of tumor necrosis factor production15014438
GO:0034097response to cytokine8774846
GO:00709353'-UTR-mediated mRNA stabilization14517288


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Ligand binding site mutations for MAPKAPK2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E190E190DSTAD1
K93L95RUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MAPKAPK2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K93L95R-1.0660979
E190E190D-0.61916822
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAPKAPK2 from PDB

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Differential gene expression and gene-gene network for MAPKAPK2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAPKAPK2 and the right PPI network was created from samples without mutations in the LBS of MAPKAPK2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MAPKAPK2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MAPKAPK2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02010StaurosporineSmall molecule
ExperimentalDB072343-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dioneSmall molecule
ExperimentalDB07406(4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDESmall molecule
ExperimentalDB07430(10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-oneSmall molecule
ExperimentalDB07431(3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-oneSmall molecule
ExperimentalDB077282-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONESmall molecule
ExperimentalDB083582-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAPKAPK2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
STUSTAUROSPORINE1nxkAE190
STUSTAUROSPORINE1nxkBE190
STUSTAUROSPORINE1nxkCE190
STUSTAUROSPORINE2pzyCE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cAE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cBE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cCE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cDE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cEE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cFE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cGE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cHE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cIE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cJE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cKE190
PDY{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE3a2cLE190
YRZN-[(3S)-PIPERIDIN-3-YL]-7,8-DIHYDRO-6H-PYRAZOLO[1,5- A]PYRROLO[3,2-E]PYRIMIDIN-5-AMINE3wi6AE190
YRZN-[(3S)-PIPERIDIN-3-YL]-7,8-DIHYDRO-6H-PYRAZOLO[1,5- A]PYRROLO[3,2-E]PYRIMIDIN-5-AMINE3wi6BE190
YRZN-[(3S)-PIPERIDIN-3-YL]-7,8-DIHYDRO-6H-PYRAZOLO[1,5- A]PYRROLO[3,2-E]PYRIMIDIN-5-AMINE3wi6CE190
YRZN-[(3S)-PIPERIDIN-3-YL]-7,8-DIHYDRO-6H-PYRAZOLO[1,5- A]PYRROLO[3,2-E]PYRIMIDIN-5-AMINE3wi6DE190
YRZN-[(3S)-PIPERIDIN-3-YL]-7,8-DIHYDRO-6H-PYRAZOLO[1,5- A]PYRROLO[3,2-E]PYRIMIDIN-5-AMINE3wi6EE190
YRZN-[(3S)-PIPERIDIN-3-YL]-7,8-DIHYDRO-6H-PYRAZOLO[1,5- A]PYRROLO[3,2-E]PYRIMIDIN-5-AMINE3wi6FE190
ADPADP1ny3AK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2jboAK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2jbpAK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2jbpBK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2jbpCK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2jbpDK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2jbpFK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2jbpGK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2jbpHK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2jbpIK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2jbpKK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2jbpLK93
F102-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE2p3gXK93
B18(4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE2pzyAK93
B18(4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE2pzyBK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokAK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokBK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokCK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokDK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokEK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokFK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokGK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokHK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokIK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokJK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokKK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3gokLK93
MK36-(5-(2-AMINOPYRIMIDIN-4-YLAMINO)-2-HYDROXYPHENYL)-N-METHYLBENZO[B]THIOPHENE-2-CARBOXAMIDE3ka0AK93
MK2N4-[7-(1-BENZOFURAN-2-YL)-1H-INDAZOL-5-YL]PYRIMIDINE-2,4-DIAMINE3kc3AK93
MK2N4-[7-(1-BENZOFURAN-2-YL)-1H-INDAZOL-5-YL]PYRIMIDINE-2,4-DIAMINE3kc3BK93
MK2N4-[7-(1-BENZOFURAN-2-YL)-1H-INDAZOL-5-YL]PYRIMIDINE-2,4-DIAMINE3kc3CK93
MK2N4-[7-(1-BENZOFURAN-2-YL)-1H-INDAZOL-5-YL]PYRIMIDINE-2,4-DIAMINE3kc3DK93
MK2N4-[7-(1-BENZOFURAN-2-YL)-1H-INDAZOL-5-YL]PYRIMIDINE-2,4-DIAMINE3kc3EK93
MK2N4-[7-(1-BENZOFURAN-2-YL)-1H-INDAZOL-5-YL]PYRIMIDINE-2,4-DIAMINE3kc3FK93
MK2N4-[7-(1-BENZOFURAN-2-YL)-1H-INDAZOL-5-YL]PYRIMIDINE-2,4-DIAMINE3kc3HK93
MK2N4-[7-(1-BENZOFURAN-2-YL)-1H-INDAZOL-5-YL]PYRIMIDINE-2,4-DIAMINE3kc3IK93
MK2N4-[7-(1-BENZOFURAN-2-YL)-1H-INDAZOL-5-YL]PYRIMIDINE-2,4-DIAMINE3kc3JK93
MK2N4-[7-(1-BENZOFURAN-2-YL)-1H-INDAZOL-5-YL]PYRIMIDINE-2,4-DIAMINE3kc3KK93
MK2N4-[7-(1-BENZOFURAN-2-YL)-1H-INDAZOL-5-YL]PYRIMIDINE-2,4-DIAMINE3kc3LK93
LX96-{3-AMINO-1-[3-(1H-INDOL-6-YL)PHENYL]-1H-PYRAZOL-4-YL}-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE3kgaAK93
HGF2-[5-(2-METHOXYETHOXY)PYRIDIN-3-YL]-8,9,10,11-TETRAHYDRO-7H-PYRIDO[3',4':4,5]PYRROLO[2,3-F]ISOQUINOLIN-7-ONE3m42AK93
05B2'-[2-(1,3-BENZODIOXOL-5-YL)PYRIMIDIN-4-YL]-5',6'-DIHYDROSPIRO[PIPERIDINE-4,7'-PYRROLO[3,2-C]PYRIDIN]-4'(1'H)-ONE3r2bBK93
P4O2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3r2yAK93
7933-{[(1R)-1-PHENYLETHYL]AMINO}-4-(PYRIDIN-4-YLAMINO)CYCLOBUT-3-ENE-1,2-DIONE3fpmAK93 E190
B98(3R)-3-(AMINOMETHYL)-9-METHOXY-1,2,3,4-TETRAHYDRO-5H-[1]BENZOTHIENO[3,2-E][1,4]DIAZEPIN-5-ONE3fykXK93 E190
L8I2'-(2-FLUOROPHENYL)-1-METHYL-6',8',9',11'-TETRAHYDROSPIRO[AZETIDINE-3,10'-PYRIDO[3',4':4,5]PYRROLO[2,3-F]ISOQUINOLIN]-7'(5'H)-ONE3m2wAK93 E190
05B2'-[2-(1,3-BENZODIOXOL-5-YL)PYRIMIDIN-4-YL]-5',6'-DIHYDROSPIRO[PIPERIDINE-4,7'-PYRROLO[3,2-C]PYRIDIN]-4'(1'H)-ONE3r2bAK93 E190
CD21-(2-AMINOETHYL)-3-[2-(QUINOLIN-3-YL)PYRIDIN-4-YL]-1H-PYRAZOLE-5-CARBOXYLIC ACID3r30AK93 E190


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Conservation information for LBS of MAPKAPK2
Multiple alignments for P49137 in multiple species
LBSAA sequence# speciesSpecies


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