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mutLBSgeneDB |
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| Gene summary for TIFA |
 Gene summary |
| Basic gene Info. | Gene symbol | TIFA |
| Gene name | TRAF-interacting protein with forkhead-associated domain | |
| Synonyms | T2BP|T6BP|TIFAA | |
| Cytomap | UCSC genome browser: 4q25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_052864.2, | |
| Description | TRAF-interacting protein with FHA domain-containing protein ATRAF-interacting protein with a forkhead-associated domainTRAF2 binding proteinTRAF2-binding proteinTRAF6 binding proteinputative MAPK-activating protein PM14putative NF-kappa-B-activating | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609028 | |
| HGNC : HGNC | ||
| HPRD : 09835 | ||
| Protein | UniProt: Q96CG3 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TIFA | |
| BioGPS: 92610 | ||
| Pathway | NCI Pathway Interaction Database: TIFA | |
| KEGG: TIFA | ||
| REACTOME: TIFA | ||
| Pathway Commons: TIFA | ||
| Context | iHOP: TIFA | |
| ligand binding site mutation search in PubMed: TIFA | ||
| UCL Cancer Institute: TIFA | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for TIFA |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S53 | S53F | HNSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TIFA |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S53 | S53F | -0.29116129 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TIFA from PDB |
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| Differential gene expression and gene-gene network for TIFA |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TIFA |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TIFA |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TIFA go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (MET,THR,SER,PHE,GLU,ASP,ALA,ASP,THR,GLU,GLU,THR) | 4ym4 | A | S53 |
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| Conservation information for LBS of TIFA |
| Multiple alignments for Q96CG3 in multiple species |
| LBS | AA sequence | # species | Species | K63 | YTFQDKQVSRV | 2 | Homo sapiens, Rattus norvegicus | K63 | YPLLSNRVSRI | 1 | Xenopus tropicalis | K63 | YIFQDKQVSRV | 1 | Bos taurus | K63 | YTFQDKQVSRI | 1 | Mus musculus | Q64 | TFQDKQVSRVQ | 2 | Homo sapiens, Rattus norvegicus | Q64 | PLLSNRVSRIQ | 1 | Xenopus tropicalis | Q64 | IFQDKQVSRVQ | 1 | Bos taurus | Q64 | TFQDKQVSRIQ | 1 | Mus musculus | R51 | VVKFGRNSNMC | 2 | Mus musculus, Rattus norvegicus | R51 | VVKFGRNSNIC | 1 | Homo sapiens | R51 | VVAFGRDYNVC | 1 | Xenopus tropicalis | R51 | VVKFGRNSHTC | 1 | Bos taurus | R67 | DKQVSRVQFSL | 2 | Homo sapiens, Bos taurus | R67 | SNRVSRIQFNL | 1 | Xenopus tropicalis | R67 | DKQVSRIQFVL | 1 | Mus musculus | R67 | DKQVSRVQFAL | 1 | Rattus norvegicus | S53 | KFGRNSNMCQY | 2 | Mus musculus, Rattus norvegicus | S53 | KFGRNSNICHY | 1 | Homo sapiens | S53 | AFGRDYNVCRY | 1 | Xenopus tropicalis | S53 | KFGRNSHTCNY | 1 | Bos taurus | S66 | QDKQVSRVQFS | 2 | Homo sapiens, Bos taurus | S66 | LSNRVSRIQFN | 1 | Xenopus tropicalis | S66 | QDKQVSRIQFV | 1 | Mus musculus | S66 | QDKQVSRVQFA | 1 | Rattus norvegicus |
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