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mutLBSgeneDB |
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| Gene summary for STK17B |
 Gene summary |
| Basic gene Info. | Gene symbol | STK17B |
| Gene name | serine/threonine kinase 17b | |
| Synonyms | DRAK2 | |
| Cytomap | UCSC genome browser: 2q32.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004226.3, | |
| Description | DAP kinase-related apoptosis-inducing protein kinase 2death-associated protein kinase-related 2serine/threonine-protein kinase 17B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604727 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000081320 | ||
| HPRD : 05289 | ||
| Vega : OTTHUMG00000132735 | ||
| Protein | UniProt: O94768 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_STK17B | |
| BioGPS: 9262 | ||
| Pathway | NCI Pathway Interaction Database: STK17B | |
| KEGG: STK17B | ||
| REACTOME: STK17B | ||
| Pathway Commons: STK17B | ||
| Context | iHOP: STK17B | |
| ligand binding site mutation search in PubMed: STK17B | ||
| UCL Cancer Institute: STK17B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 9786912 | GO:0035556 | intracellular signal transduction | 9786912 |
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| Ligand binding site mutations for STK17B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E117 | E117K | BLCA | 1 | L39 | G40W | LUAD | 1 | I94 | R92C | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for STK17B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E117 | E117K | -0.80101643 | I94 | R92C | -0.7432757 | L39 | G40W | -0.41285946 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for STK17B from PDB |
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| Differential gene expression and gene-gene network for STK17B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for STK17B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for STK17B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB04216 | Quercetin | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of STK17B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | QUE | QUERCETIN | 3lm5 | A | I94 | EBD | [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]-5-METHYLPYRIMIDIN-2-YL}AMINO)PHENYL]ACETONITRILE | 3lm0 | A | L39 E117 |
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| Conservation information for LBS of STK17B |
| Multiple alignments for O94768 in multiple species |
| LBS | AA sequence | # species | Species | A113 | LVLEYAAGGEI | 2 | Mus musculus, Rattus norvegicus | A113 | LILEYAAGGEI | 1 | Homo sapiens | A60 | TGQEYAAKFLK | 2 | Homo sapiens, Rattus norvegicus | A60 | TGQEYAAKSLK | 1 | Mus musculus | D179 | DIKIVDFGMSR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E111 | IILVLEYAAGG | 2 | Mus musculus, Rattus norvegicus | E111 | IILILEYAAGG | 1 | Homo sapiens | E117 | YAAGGEIFNLC | 2 | Mus musculus, Rattus norvegicus | E117 | YAAGGEIFSLC | 1 | Homo sapiens | E80 | AEILHEIAVLE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F180 | IKIVDFGMSRK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G116 | EYAAGGEIFNL | 2 | Mus musculus, Rattus norvegicus | G116 | EYAAGGEIFSL | 1 | Homo sapiens | I94 | SCPHVINLHEV | 2 | Mus musculus, Rattus norvegicus | I94 | SCPRVINLHEV | 1 | Homo sapiens | K37 | YTLTPKELGRG | 2 | Mus musculus, Rattus norvegicus | K37 | YILTSKELGRG | 1 | Homo sapiens | K62 | QEYAAKFLKKR | 2 | Homo sapiens, Rattus norvegicus | K62 | QEYAAKSLKKR | 1 | Mus musculus | L110 | EIILVLEYAAG | 2 | Mus musculus, Rattus norvegicus | L110 | EIILILEYAAG | 1 | Homo sapiens | L165 | KPQNILLSSIY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L39 | LTPKELGRGKF | 2 | Mus musculus, Rattus norvegicus | L39 | LTSKELGRGKF | 1 | Homo sapiens | N163 | DLKPQNILLSS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q162 | LDLKPQNILLS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V178 | GDIKIVDFGMS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V47 | GKFAVVRQCIS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y112 | ILVLEYAAGGE | 2 | Mus musculus, Rattus norvegicus | Y112 | ILILEYAAGGE | 1 | Homo sapiens |
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