mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for STK17B
Gene summary
Basic gene Info.Gene symbolSTK17B
Gene nameserine/threonine kinase 17b
CytomapUCSC genome browser: 2q32.3
Type of geneprotein-coding
DescriptionDAP kinase-related apoptosis-inducing protein kinase 2death-associated protein kinase-related 2serine/threonine-protein kinase 17B
Modification date20141207
dbXrefs MIM : 604727
Ensembl : ENSG00000081320
HPRD : 05289
Vega : OTTHUMG00000132735
ProteinUniProt: O94768
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STK17B
BioGPS: 9262
PathwayNCI Pathway Interaction Database: STK17B
Pathway Commons: STK17B
ContextiHOP: STK17B
ligand binding site mutation search in PubMed: STK17B
UCL Cancer Institute: STK17B
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006468protein phosphorylation9786912
GO:0035556intracellular signal transduction9786912

Ligand binding site mutations for STK17B

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for STK17B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for STK17B from PDB

Differential gene expression and gene-gene network for STK17B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of STK17B and the right PPI network was created from samples without mutations in the LBS of STK17B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for STK17B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for STK17B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB04216QuercetinSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of STK17B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of STK17B
Multiple alignments for O94768 in multiple species
LBSAA sequence# speciesSpecies
A113LVLEYAAGGEI2Mus musculus, Rattus norvegicus
A113LILEYAAGGEI1Homo sapiens
A60TGQEYAAKFLK2Homo sapiens, Rattus norvegicus
A60TGQEYAAKSLK1Mus musculus
D179DIKIVDFGMSR3Homo sapiens, Mus musculus, Rattus norvegicus
E111IILVLEYAAGG2Mus musculus, Rattus norvegicus
E111IILILEYAAGG1Homo sapiens
E117YAAGGEIFNLC2Mus musculus, Rattus norvegicus
E117YAAGGEIFSLC1Homo sapiens
E80AEILHEIAVLE3Homo sapiens, Mus musculus, Rattus norvegicus
F180IKIVDFGMSRK3Homo sapiens, Mus musculus, Rattus norvegicus
G116EYAAGGEIFNL2Mus musculus, Rattus norvegicus
G116EYAAGGEIFSL1Homo sapiens
I94SCPHVINLHEV2Mus musculus, Rattus norvegicus
I94SCPRVINLHEV1Homo sapiens
K37YTLTPKELGRG2Mus musculus, Rattus norvegicus
K37YILTSKELGRG1Homo sapiens
K62QEYAAKFLKKR2Homo sapiens, Rattus norvegicus
K62QEYAAKSLKKR1Mus musculus
L110EIILVLEYAAG2Mus musculus, Rattus norvegicus
L110EIILILEYAAG1Homo sapiens
L165KPQNILLSSIY3Homo sapiens, Mus musculus, Rattus norvegicus
L39LTPKELGRGKF2Mus musculus, Rattus norvegicus
L39LTSKELGRGKF1Homo sapiens
N163DLKPQNILLSS3Homo sapiens, Mus musculus, Rattus norvegicus
Q162LDLKPQNILLS3Homo sapiens, Mus musculus, Rattus norvegicus
V178GDIKIVDFGMS3Homo sapiens, Mus musculus, Rattus norvegicus
V47GKFAVVRQCIS3Homo sapiens, Mus musculus, Rattus norvegicus
Y112ILVLEYAAGGE2Mus musculus, Rattus norvegicus
Y112ILILEYAAGGE1Homo sapiens

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