mutLBSgeneDB |
Gene summary for CYTH2 |
Gene summary |
Basic gene Info. | Gene symbol | CYTH2 |
Gene name | cytohesin 2 | |
Synonyms | ARNO|CTS18|CTS18.1|PSCD2|PSCD2L|SEC7L|Sec7p-L|Sec7p-like | |
Cytomap | UCSC genome browser: 19q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_004228.6, NM_017457.5, | |
Description | ARF exchange factorARF nucleotide-binding site openerCTC-273B12.8PH, SEC7 and coiled-coil domain-containing protein 2cytohesin-2pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)pleckstrin homology, Sec7 and coiled/coil domains 2 (cyt | |
Modification date | 20141207 | |
dbXrefs | MIM : 602488 | |
HGNC : HGNC | ||
HPRD : 03925 | ||
Protein | UniProt: Q99418 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CYTH2 | |
BioGPS: 9266 | ||
Pathway | NCI Pathway Interaction Database: CYTH2 | |
KEGG: CYTH2 | ||
REACTOME: CYTH2 | ||
Pathway Commons: CYTH2 | ||
Context | iHOP: CYTH2 | |
ligand binding site mutation search in PubMed: CYTH2 | ||
UCL Cancer Institute: CYTH2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CYTH2 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | I193 | V192I | OV | 1 | M164 | A166V | UCEC | 1 | N240 | R239Q | UCEC | 1 | I193 | A191V | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CYTH2 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | N240 | R239Q | -1.3091601 | I193 | A191V | -0.72631609 | M164 | A166V | -0.56512635 | I193 | V192I | -0.55367664 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CYTH2 from PDB |
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Differential gene expression and gene-gene network for CYTH2 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CYTH2 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CYTH2 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB01863 | Inositol 1,3,4,5-Tetrakisphosphate | Small molecule | |
Experimental | DB01942 | Formic Acid | Small molecule | |
Experimental | DB03401 | D-Myo-Inositol-1,4,5-Triphosphate | Small molecule | |
Experimental | DB04530 | S,S-(2-Hydroxyethyl)Thiocysteine | Small molecule | |
Experimental | DB07348 | 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CYTH2 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | JAF | N-(4-HYDROXY-2,6-DIMETHYLPHENYL)-4- METHOXYBENZENESULFONAMIDE | 4jmo | A | I193 | HRC | N-(4-HYDROXY-2,6-DIMETHYLPHENYL)BENZENESULFONAMIDE | 4jwl | A | I193 | HRC | N-(4-HYDROXY-2,6-DIMETHYLPHENYL)BENZENESULFONAMIDE | 4jxh | A | M164 I193 | HRC | N-(4-HYDROXY-2,6-DIMETHYLPHENYL)BENZENESULFONAMIDE | 4l5m | A | M164 I193 | MN | MANGANESE(2+) | 1r8m | E | N240 |
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Conservation information for LBS of CYTH2 |
Multiple alignments for Q99418 in multiple species |
LBS | AA sequence | # species | Species | D131 | LHAFVDLHEFT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E241 | DSIRNEPFKIP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | F151 | QFLWSFRLPGE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | F243 | IRNEPFKIPED | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H127 | NLAVLHAFVDL | 2 | Homo sapiens, Bos taurus | H127 | NLSVLHAFVDL | 2 | Mus musculus, Rattus norvegicus | I160 | GEAQKIDRMME | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I193 | LSFAVIMLNTS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I245 | NEPFKIPEDDG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K244 | RNEPFKIPEDD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L148 | ALRQFLWSFRL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L153 | LWSFRLPGEAQ | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | M164 | KIDRMMEAFAQ | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | N240 | YDSIRNEPFKI | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | P13 | PPDLTPEERME | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | P154 | WSFRLPGEAQK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | P8 | DGVYEPPDLTP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R152 | FLWSFRLPGEA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus |
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