mutLBSgeneDB |
Gene summary for SOCS6 |
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Basic gene Info. | Gene symbol | SOCS6 |
Gene name | suppressor of cytokine signaling 6 | |
Synonyms | CIS-4|CIS4|HSPC060|SOCS-4|SOCS-6|SOCS4|SSI4|STAI4|STATI4 | |
Cytomap | UCSC genome browser: 18q22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_004232.3, | |
Description | STAT induced STAT inhibitor-4cytokine-inducible SH2 protein 4suppressor of cytokine signaling 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605118 | |
HGNC : HGNC | ||
Ensembl : ENSG00000170677 | ||
HPRD : 05491 | ||
Vega : OTTHUMG00000132816 | ||
Protein | UniProt: O14544 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SOCS6 | |
BioGPS: 9306 | ||
Pathway | NCI Pathway Interaction Database: SOCS6 | |
KEGG: SOCS6 | ||
REACTOME: SOCS6 | ||
Pathway Commons: SOCS6 | ||
Context | iHOP: SOCS6 | |
ligand binding site mutation search in PubMed: SOCS6 | ||
UCL Cancer Institute: SOCS6 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for SOCS6 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | D464 | I462V | HNSC | 1 | R476 | R476Q | STAD | 1 | A469 | N467D | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for SOCS6 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D464 | I462V | -0.98065033 | R476 | R476Q | -0.85741174 | A469 | N467D | -0.69249526 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for SOCS6 |
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Phenotype information for SOCS6 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for SOCS6 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ASN,ASN,TYR,VAL,TYR,ILE,ASP,PRO,THR) | 2vif | A | D464 A469 R476 |
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Conservation information for LBS of SOCS6 |
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LBS | AA sequence | # species | Species |
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