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mutLBSgeneDB |
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| Gene summary for SLIT2 |
 Gene summary |
| Basic gene Info. | Gene symbol | SLIT2 |
| Gene name | slit homolog 2 (Drosophila) | |
| Synonyms | SLIL3|Slit-2 | |
| Cytomap | UCSC genome browser: 4p15.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001289135.1, NM_001289136.1,NM_004787.2, | |
| Description | slit homolog 2 protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603746 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000145147 | ||
| HPRD : 04776 | ||
| Vega : OTTHUMG00000128551 | ||
| Protein | UniProt: O94813 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLIT2 | |
| BioGPS: 9353 | ||
| Pathway | NCI Pathway Interaction Database: SLIT2 | |
| KEGG: SLIT2 | ||
| REACTOME: SLIT2 | ||
| Pathway Commons: SLIT2 | ||
| Context | iHOP: SLIT2 | |
| ligand binding site mutation search in PubMed: SLIT2 | ||
| UCL Cancer Institute: SLIT2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0001933 | negative regulation of protein phosphorylation | 18345009 | GO:0002689 | negative regulation of leukocyte chemotaxis | 11309622 | GO:0007411 | axon guidance | 11748139 | GO:0008045 | motor neuron axon guidance | 10102268 | GO:0010593 | negative regulation of lamellipodium assembly | 16439689 | GO:0010596 | negative regulation of endothelial cell migration | 18345009 | GO:0014912 | negative regulation of smooth muscle cell migration | 16439689 | GO:0021834 | chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration | 11748139 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration | 15207848 | GO:0030336 | negative regulation of cell migration | 19005219 | GO:0030837 | negative regulation of actin filament polymerization | 19759280 | GO:0031290 | retinal ganglion cell axon guidance | 10864954 | GO:0043086 | negative regulation of catalytic activity | 16439689 | GO:0043116 | negative regulation of vascular permeability | 18345009 | GO:0048754 | branching morphogenesis of an epithelial tube | 18345009 | GO:0048846 | axon extension involved in axon guidance | 16840550 | GO:0050919 | negative chemotaxis | 11748139 | GO:0050929 | induction of negative chemotaxis | 10197527 | GO:0051058 | negative regulation of small GTPase mediated signal transduction | 16439689 | GO:0071504 | cellular response to heparin | 17062560 | GO:0071672 | negative regulation of smooth muscle cell chemotaxis | 16439689 | GO:0071676 | negative regulation of mononuclear cell migration | 16439689 | GO:0090024 | negative regulation of neutrophil chemotaxis | 19759280 | GO:0090260 | negative regulation of retinal ganglion cell axon guidance | 17062560 | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 16439689 |
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| Ligand binding site mutations for SLIT2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H833 | S831Y | LUAD | 1 | H833 | L832V | OV | 1 | H833 | G834R | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SLIT2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H833 | L832V | -1.5278007 | H833 | S831Y | -0.49976779 | H833 | G834R | -0.47312092 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SLIT2 from PDB |
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| Differential gene expression and gene-gene network for SLIT2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SLIT2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C2239176 | Carcinoma, Hepatocellular | 1 | Biomarker, PostTranslationalModification |
| umls:C0014556 | Epilepsy, Temporal Lobe | 1 | Biomarker |
| umls:C0149925 | Small Cell Lung Carcinoma | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SLIT2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SLIT2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | SO4 | SULFATE | 2wfh | A | H833 | SO4 | SULFATE | 2wfh | B | H833 |
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| Conservation information for LBS of SLIT2 |
| Multiple alignments for O94813 in multiple species |
| LBS | AA sequence | # species | Species | A858 | HLAIGANPLYC | 2 | Homo sapiens, Mus musculus | A858 | HIAVGSNSLYC | 1 | Caenorhabditis elegans | H833 | RLLSLHGNDIS | 2 | Homo sapiens, Mus musculus | H833 | RILSLHGNDIS | 1 | Caenorhabditis elegans | Y810 | TLILSYNRLRC | 2 | Homo sapiens, Mus musculus | Y810 | TLIISYNKLRC | 1 | Caenorhabditis elegans |
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