mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PPIG
Gene summary
Basic gene Info.Gene symbolPPIG
Gene namepeptidylprolyl isomerase G (cyclophilin G)
SynonymsCARS-Cyp|CYP|SCAF10|SRCyp
CytomapUCSC genome browser: 2q31.1
Type of geneprotein-coding
RefGenesNM_004792.2,
DescriptionCARS-cyclophilinCASP10Clk-associating RS-cyclophilinPPIase GSR-cyclophilinSR-cypSR-related CTD-associated factor 10cyclophilin Gpeptidyl-prolyl cis-trans isomerase Gpeptidyl-prolyl isomerase G (cyclophilin G)rotamase G
Modification date20141207
dbXrefs MIM : 606093
HGNC : HGNC
Ensembl : ENSG00000138398
HPRD : 12083
Vega : OTTHUMG00000132206
ProteinUniProt: Q13427
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PPIG
BioGPS: 9360
PathwayNCI Pathway Interaction Database: PPIG
KEGG: PPIG
REACTOME: PPIG
Pathway Commons: PPIG
ContextiHOP: PPIG
ligand binding site mutation search in PubMed: PPIG
UCL Cancer Institute: PPIG
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for PPIG
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F125I126VCOAD2
G84R85QKIRC1
A113M112VSKCM1
Q123G121DUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PPIG
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G84R85Q-1.2433114
F125I126V-1.1096978
A113M112V-0.83264934
Q123G121D-0.53532164
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPIG from PDB
PDB IDPDB titlePDB structure
2WFIATOMIC RESOLUTION CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF HUMAN CYCLOPHILIN G

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Differential gene expression and gene-gene network for PPIG
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PPIG and the right PPI network was created from samples without mutations in the LBS of PPIG. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PPIG
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PPIG
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00172L-ProlineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPIG go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (DAL,MLE,MLE,MVA,BMT,ABA,SAR,MLE,VAL,MLE,ALA)2wfjAG84 A113 Q123 F125


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Conservation information for LBS of PPIG
Multiple alignments for Q13427 in multiple species
LBSAA sequence# speciesSpecies
A113FLLSMANRGKD3Homo sapiens, Mus musculus, Rattus norvegicus
F125NGSQFFITTKP3Homo sapiens, Mus musculus, Rattus norvegicus
F72RVVKDFMVQGG3Homo sapiens, Mus musculus, Rattus norvegicus
G84FSEGNGRGGES3Homo sapiens, Mus musculus, Rattus norvegicus
H133TKPTPHLDGHH3Homo sapiens, Mus musculus, Rattus norvegicus
H138HLDGHHVVFGQ3Homo sapiens, Mus musculus, Rattus norvegicus
L134KPTPHLDGHHV3Homo sapiens, Mus musculus, Rattus norvegicus
M73VVKDFMVQGGD3Homo sapiens, Mus musculus, Rattus norvegicus
N114LLSMANRGKDT3Homo sapiens, Mus musculus, Rattus norvegicus
Q123DTNGSQFFITT3Homo sapiens, Mus musculus, Rattus norvegicus
Q75KDFMVQGGDFS3Homo sapiens, Mus musculus, Rattus norvegicus
R115LSMANRGKDTN3Homo sapiens, Mus musculus, Rattus norvegicus
R67SCLFHRVVKDF3Homo sapiens, Mus musculus, Rattus norvegicus


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