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mutLBSgeneDB |
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| Gene summary for PPIG |
 Gene summary |
| Basic gene Info. | Gene symbol | PPIG |
| Gene name | peptidylprolyl isomerase G (cyclophilin G) | |
| Synonyms | CARS-Cyp|CYP|SCAF10|SRCyp | |
| Cytomap | UCSC genome browser: 2q31.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004792.2, | |
| Description | CARS-cyclophilinCASP10Clk-associating RS-cyclophilinPPIase GSR-cyclophilinSR-cypSR-related CTD-associated factor 10cyclophilin Gpeptidyl-prolyl cis-trans isomerase Gpeptidyl-prolyl isomerase G (cyclophilin G)rotamase G | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606093 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000138398 | ||
| HPRD : 12083 | ||
| Vega : OTTHUMG00000132206 | ||
| Protein | UniProt: Q13427 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PPIG | |
| BioGPS: 9360 | ||
| Pathway | NCI Pathway Interaction Database: PPIG | |
| KEGG: PPIG | ||
| REACTOME: PPIG | ||
| Pathway Commons: PPIG | ||
| Context | iHOP: PPIG | |
| ligand binding site mutation search in PubMed: PPIG | ||
| UCL Cancer Institute: PPIG | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PPIG |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F125 | I126V | COAD | 2 | G84 | R85Q | KIRC | 1 | A113 | M112V | SKCM | 1 | Q123 | G121D | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PPIG |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | G84 | R85Q | -1.2433114 | F125 | I126V | -1.1096978 | A113 | M112V | -0.83264934 | Q123 | G121D | -0.53532164 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PPIG from PDB |
| PDB ID | PDB title | PDB structure | 2WFI | ATOMIC RESOLUTION CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF HUMAN CYCLOPHILIN G |  |
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| Differential gene expression and gene-gene network for PPIG |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PPIG |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PPIG |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00172 | L-Proline | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PPIG go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (DAL,MLE,MLE,MVA,BMT,ABA,SAR,MLE,VAL,MLE,ALA) | 2wfj | A | G84 A113 Q123 F125 |
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| Conservation information for LBS of PPIG |
| Multiple alignments for Q13427 in multiple species |
| LBS | AA sequence | # species | Species | A113 | FLLSMANRGKD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F125 | NGSQFFITTKP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F72 | RVVKDFMVQGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G84 | FSEGNGRGGES | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H133 | TKPTPHLDGHH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H138 | HLDGHHVVFGQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L134 | KPTPHLDGHHV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M73 | VVKDFMVQGGD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N114 | LLSMANRGKDT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q123 | DTNGSQFFITT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q75 | KDFMVQGGDFS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R115 | LSMANRGKDTN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R67 | SCLFHRVVKDF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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