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mutLBSgeneDB |
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| Gene summary for PLAA |
 Gene summary |
| Basic gene Info. | Gene symbol | PLAA |
| Gene name | phospholipase A2-activating protein | |
| Synonyms | DOA1|PLA2P|PLAP | |
| Cytomap | UCSC genome browser: 9p21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004253.3, NM_001031689.2, | |
| Description | DOA1 homologphospholipase A-2-activating proteinphospholipase A2 activating protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603873 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000137055 | ||
| HPRD : 04850 | ||
| Vega : OTTHUMG00000019708 | ||
| Protein | UniProt: Q9Y263 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PLAA | |
| BioGPS: 9373 | ||
| Pathway | NCI Pathway Interaction Database: PLAA | |
| KEGG: PLAA | ||
| REACTOME: PLAA | ||
| Pathway Commons: PLAA | ||
| Context | iHOP: PLAA | |
| ligand binding site mutation search in PubMed: PLAA | ||
| UCL Cancer Institute: PLAA | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PLAA |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K554 | K554N | GBM | 1 | F611 | V610A | OV | 1 | A654 | N655T | UCEC | 1 | K554 | G553C | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PLAA |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | F611 | V610A | -1.2003444 | K554 | K554N | -1.1271724 | K554 | G553C | -0.56914784 | A654 | N655T | -0.25702075 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PLAA from PDB |
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| Differential gene expression and gene-gene network for PLAA |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PLAA |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0021368 | Inflammation | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PLAA |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PLAA go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (LEU,TYR) | 3ebb | A | K554 F611 | III | Peptide ligand (ASP,LEU,TYR,GLY) | 3ebb | B | K554 F611 A654 | III | Peptide ligand (LEU,TYR,GLY) | 3ebb | C | K554 F611 A654 | III | Peptide ligand (ASP,LEU,TYR) | 3ebb | D | K554 F611 A654 |
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| Conservation information for LBS of PLAA |
| Multiple alignments for Q9Y263 in multiple species |
| LBS | AA sequence | # species | Species | A654 | GK--PANQLLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A654 | GNFESINVMLA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A654 | GNKNITLTMLT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D615 | VFPALDILRLS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D615 | RFPALDALRLL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D615 | KTPAYDIVRLI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F611 | PEDIVFPALDI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F611 | SLAERFPALDA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F611 | --EIKTPAYDI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I551 | ANPTQILGKLK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I551 | ANVPAMCQRLR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I551 | YNPDTIFNGIV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K554 | TQILGKLKELN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K554 | PAMCQRLRSLN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K554 | DTIFNGIVKIN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L658 | PANQLLALRTF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L658 | SINVMLALRGL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L658 | ITLTMLTVRIL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N547 | TFDQANPTQIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N547 | LFSNANVPAMC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N547 | IMENYNPDTIF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P612 | EDIVFPALDIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P612 | LAERFPALDAL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P612 | -EIKTPAYDIV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q550 | QANPTQILGKL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q550 | NANVPAMCQRL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q550 | NYNPDTIFNGI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) |
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