mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PLAA
Gene summary
Basic gene Info.Gene symbolPLAA
Gene namephospholipase A2-activating protein
CytomapUCSC genome browser: 9p21
Type of geneprotein-coding
DescriptionDOA1 homologphospholipase A-2-activating proteinphospholipase A2 activating protein
Modification date20141207
dbXrefs MIM : 603873
Ensembl : ENSG00000137055
HPRD : 04850
Vega : OTTHUMG00000019708
ProteinUniProt: Q9Y263
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PLAA
BioGPS: 9373
PathwayNCI Pathway Interaction Database: PLAA
Pathway Commons: PLAA
ContextiHOP: PLAA
ligand binding site mutation search in PubMed: PLAA
UCL Cancer Institute: PLAA
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for PLAA

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PLAA
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PLAA from PDB

Differential gene expression and gene-gene network for PLAA
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PLAA and the right PPI network was created from samples without mutations in the LBS of PLAA. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PLAA
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PLAA
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PLAA go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (LEU,TYR)3ebbAK554 F611
IIIPeptide ligand (ASP,LEU,TYR,GLY)3ebbBK554 F611 A654
IIIPeptide ligand (LEU,TYR,GLY)3ebbCK554 F611 A654
IIIPeptide ligand (ASP,LEU,TYR)3ebbDK554 F611 A654

Conservation information for LBS of PLAA
Multiple alignments for Q9Y263 in multiple species
LBSAA sequence# speciesSpecies
A654GK--PANQLLA3Homo sapiens, Mus musculus, Rattus norvegicus
A654GNFESINVMLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A654GNKNITLTMLT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D615VFPALDILRLS3Homo sapiens, Mus musculus, Rattus norvegicus
D615RFPALDALRLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D615KTPAYDIVRLI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F611PEDIVFPALDI3Homo sapiens, Mus musculus, Rattus norvegicus
F611SLAERFPALDA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F611--EIKTPAYDI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I551ANPTQILGKLK3Homo sapiens, Mus musculus, Rattus norvegicus
I551ANVPAMCQRLR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I551YNPDTIFNGIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K554TQILGKLKELN3Homo sapiens, Mus musculus, Rattus norvegicus
K554PAMCQRLRSLN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K554DTIFNGIVKIN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L658PANQLLALRTF3Homo sapiens, Mus musculus, Rattus norvegicus
L658SINVMLALRGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L658ITLTMLTVRIL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N547TFDQANPTQIL3Homo sapiens, Mus musculus, Rattus norvegicus
N547LFSNANVPAMC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N547IMENYNPDTIF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P612EDIVFPALDIL3Homo sapiens, Mus musculus, Rattus norvegicus
P612LAERFPALDAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P612-EIKTPAYDIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q550QANPTQILGKL3Homo sapiens, Mus musculus, Rattus norvegicus
Q550NANVPAMCQRL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q550NYNPDTIFNGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

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