mutLBSgeneDB |
Gene summary for GRHPR |
Gene summary |
Basic gene Info. | Gene symbol | GRHPR |
Gene name | glyoxylate reductase/hydroxypyruvate reductase | |
Synonyms | GLXR|GLYD|PH2 | |
Cytomap | UCSC genome browser: 9q12 | |
Type of gene | protein-coding | |
RefGenes | NM_012203.1, | |
Description | glycerate-2-dehydrogenase | |
Modification date | 20141219 | |
dbXrefs | MIM : 604296 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137106 | ||
HPRD : 05052 | ||
Vega : OTTHUMG00000019914 | ||
Protein | UniProt: Q9UBQ7 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GRHPR | |
BioGPS: 9380 | ||
Pathway | NCI Pathway Interaction Database: GRHPR | |
KEGG: GRHPR | ||
REACTOME: GRHPR | ||
Pathway Commons: GRHPR | ||
Context | iHOP: GRHPR | |
ligand binding site mutation search in PubMed: GRHPR | ||
UCL Cancer Institute: GRHPR | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0051259 | protein oligomerization | 16756993 | GO:0055114 | oxidation-reduction process | 10484776 |
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Ligand binding site mutations for GRHPR |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R188 | E190Q | BLCA | 1 | R245 | D247Y | COAD | 1 | S82 | M81V | COAD | 1 | R245 | D247E | LUAD | 1 | L107 | D105H | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for GRHPR |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R245 | D247Y | -0.86690423 | R245 | D247E | -0.77772446 | S82 | M81V | -0.73138155 | L107 | D105H | -0.50056868 | R188 | E190Q | -0.47454191 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for GRHPR from PDB |
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Differential gene expression and gene-gene network for GRHPR |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for GRHPR |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0268165 | Primary hyperoxaluria type 2 | 8 | Biomarker, GeneticVariation |
umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for GRHPR |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of GRHPR go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NDP | NADPH | 2gcg | A | R188 R245 | NDP | NADPH | 2gcg | B | R188 R245 | NDP | NADPH | 2gcg | C | R188 R245 | NDP | NADPH | 2gcg | D | R188 R245 | DGY | D-GLYCERIC ACID | 2gcg | A | S82 L107 R245 | DGY | D-GLYCERIC ACID | 2gcg | C | S82 L107 R245 |
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Conservation information for LBS of GRHPR |
Multiple alignments for Q9UBQ7 in multiple species |
LBS | AA sequence | # species | Species | A215 | DFIVVACSLTP | 1 | Homo sapiens | A215 | DILVVACPLTE | 1 | Arabidopsis thaliana | A215 | DFIVVSCSLTP | 1 | Mus musculus | C216 | FIVVACSLTPA | 1 | Homo sapiens | C216 | ILVVACPLTEQ | 1 | Arabidopsis thaliana | C216 | FIVVSCSLTPD | 1 | Mus musculus | D269 | AAAGLDVTSPE | 1 | Homo sapiens | D269 | GGAALDVFEQE | 1 | Arabidopsis thaliana | D269 | AAAGLDVTTPE | 1 | Mus musculus | G160 | TVGIIGLGRIG | 1 | Homo sapiens | G160 | SVGIIGLGRIG | 1 | Arabidopsis thaliana | G160 | TVGIVGLGRIG | 1 | Mus musculus | G162 | GIIGLGRIGQA | 1 | Homo sapiens | G162 | GIIGLGRIGTA | 1 | Arabidopsis thaliana | G162 | GIVGLGRIGQA | 1 | Mus musculus | G184 | RFLYTGRQPRP | 2 | Homo sapiens, Mus musculus | G184 | -INYYSRTIKP | 1 | Arabidopsis thaliana | G295 | ILPHIGSATHR | 1 | Homo sapiens | G295 | LLPHVGSGTVE | 1 | Arabidopsis thaliana | G295 | ILPHIGSATYK | 1 | Mus musculus | G84 | STMSVGIDHLA | 1 | Homo sapiens | G84 | SSFSVGLDKID | 1 | Arabidopsis thaliana | G84 | STLSVGVDHLA | 1 | Mus musculus | H293 | CVILPHIGSAT | 2 | Homo sapiens, Mus musculus | H293 | VVLLPHVGSGT | 1 | Arabidopsis thaliana | I159 | STVGIIGLGRI | 1 | Homo sapiens | I159 | KSVGIIGLGRI | 1 | Arabidopsis thaliana | I159 | STVGIVGLGRI | 1 | Mus musculus | I164 | IGLGRIGQAIA | 1 | Homo sapiens | I164 | IGLGRIGTAIA | 1 | Arabidopsis thaliana | I164 | VGLGRIGQAIA | 1 | Mus musculus | I243 | AVFINISRGDV | 1 | Homo sapiens | I243 | GVLINIGRGPH | 1 | Arabidopsis thaliana | I243 | AIFINISRGDV | 1 | Mus musculus | L107 | YTPDVLTDTTA | 1 | Homo sapiens | L107 | NTPDVLTEDVA | 1 | Arabidopsis thaliana | L107 | YTPGVLTDATA | 1 | Mus musculus | L161 | VGIIGLGRIGQ | 1 | Homo sapiens | L161 | VGIIGLGRIGT | 1 | Arabidopsis thaliana | L161 | VGIVGLGRIGQ | 1 | Mus musculus | L59 | GLLCLLSDHVD | 1 | Homo sapiens | L59 | -VVGNASAGAD | 1 | Arabidopsis thaliana | L59 | GLLCRLSDRVD | 1 | Mus musculus | Q186 | LYTGRQPRPEE | 1 | Homo sapiens | Q186 | NYYSRTIKPDV | 1 | Arabidopsis thaliana | Q186 | LYTGRQPRPQE | 1 | Mus musculus | R163 | IIGLGRIGQAI | 1 | Homo sapiens | R163 | IIGLGRIGTAI | 1 | Arabidopsis thaliana | R163 | IVGLGRIGQAI | 1 | Mus musculus | R185 | FLYTGRQPRPE | 1 | Homo sapiens | R185 | INYYSRTIKPD | 1 | Arabidopsis thaliana | R185 | FLYTGRQPRPQ | 1 | Mus musculus | R188 | TGRQPRPEEAA | 1 | Homo sapiens | R188 | YSRTIKPDVAY | 1 | Arabidopsis thaliana | R188 | TGRQPRPQEAA | 1 | Mus musculus | R245 | FINISRGDVVN | 2 | Homo sapiens, Mus musculus | R245 | LINIGRGPHVD | 1 | Arabidopsis thaliana | S217 | IVVACSLTPAT | 1 | Homo sapiens | S217 | LVVACPLTEQT | 1 | Arabidopsis thaliana | S217 | IVVSCSLTPDT | 1 | Mus musculus | S244 | VFINISRGDVV | 1 | Homo sapiens | S244 | VLINIGRGPHV | 1 | Arabidopsis thaliana | S244 | IFINISRGDVV | 1 | Mus musculus | S296 | LPHIGSATHRT | 1 | Homo sapiens | S296 | LPHVGSGTVET | 1 | Arabidopsis thaliana | S296 | LPHIGSATYKT | 1 | Mus musculus | S82 | VISTMSVGIDH | 1 | Homo sapiens | S82 | IVSSFSVGLDK | 1 | Arabidopsis thaliana | S82 | VISTLSVGVDH | 1 | Mus musculus | T111 | VLTDTTAELAV | 1 | Homo sapiens | T111 | VLTEDVADLAI | 1 | Arabidopsis thaliana | T111 | VLTDATAELAV | 1 | Mus musculus | T183 | QRFLYTGRQPR | 2 | Homo sapiens, Mus musculus | T183 | P-INYYSRTIK | 1 | Arabidopsis thaliana | T222 | SLTPATEGLCN | 1 | Homo sapiens | T222 | PLTEQTRHIVD | 1 | Arabidopsis thaliana | T222 | SLTPDTMGLCS | 1 | Mus musculus | V83 | ISTMSVGIDHL | 1 | Homo sapiens | V83 | VSSFSVGLDKI | 1 | Arabidopsis thaliana | V83 | ISTLSVGVDHL | 1 | Mus musculus |
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