mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ACTR8
Gene summary
Basic gene Info.Gene symbolACTR8
Gene nameARP8 actin-related protein 8 homolog (yeast)
CytomapUCSC genome browser: -
Type of geneprotein-coding
DescriptionINO80 complex subunit Nactin-related protein 8
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000113812
HPRD : 09792
Vega : OTTHUMG00000158279
ProteinUniProt: Q9H981
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ACTR8
BioGPS: 93973
PathwayNCI Pathway Interaction Database: ACTR8
Pathway Commons: ACTR8
ContextiHOP: ACTR8
ligand binding site mutation search in PubMed: ACTR8
UCL Cancer Institute: ACTR8
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for ACTR8

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ACTR8
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ACTR8 from PDB

Differential gene expression and gene-gene network for ACTR8
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ACTR8 and the right PPI network was created from samples without mutations in the LBS of ACTR8. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ACTR8
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ACTR8
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ACTR8 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ATPATP4fo0AS55 G311 Q344

Conservation information for LBS of ACTR8
Multiple alignments for Q9H981 in multiple species
LBSAA sequence# speciesSpecies
D286IVDVGDQKTSV2Homo sapiens, Bos taurus
D286VVDVGDQKTSV2Danio rerio, Mus musculus
D286IVNIGAQTSTV1Arabidopsis thaliana
D286VVNIGAQVTQV1Oryza sativa subsp. japonica
D286VVDIGAQKTSI1Drosophila melanogaster
D286VVDMGAQKTSI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D286VVNIGAAETRI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E348LQHLKETFCHL3Homo sapiens, Mus musculus, Bos taurus
E348LNQLKESFCEI1Arabidopsis thaliana
E348LNKLKESYSQI1Oryza sativa subsp. japonica
E348LDELKEKFCHL1Drosophila melanogaster
E348LQQLKESFCHL1Danio rerio
E348ANALKIKYCGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E348AERLKKNFTTF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F544GGGLMFHKAQE3Homo sapiens, Mus musculus, Bos taurus
F544GGAGLTKGLVA1Arabidopsis thaliana
F544GGTASTAGLAP1Oryza sativa subsp. japonica
F544GSSAKLPGLAA1Drosophila melanogaster
F544GGGLLFHGAQE1Danio rerio
F544GGAGQFPGFAH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F544GGSSKIPALDF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G285CIVDVGDQKTS2Homo sapiens, Bos taurus
G285CVVDVGDQKTS2Danio rerio, Mus musculus
G285CIVNIGAQTST1Arabidopsis thaliana
G285CVVNIGAQVTQ1Oryza sativa subsp. japonica
G285CVVDIGAQKTS1Drosophila melanogaster
G285CVVDMGAQKTS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G285CVVNIGAAETR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G311CLAYGGSDVSR3Homo sapiens, Mus musculus, Bos taurus
G311ILPFGGEDICR1Arabidopsis thaliana
G311ALPYGGDDISR1Oryza sativa subsp. japonica
G311RLSYGGGDLDQ1Drosophila melanogaster
G311CLAYGGSDVTR1Danio rerio
G311KINYGGDDITL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G311TLDYGGDDITR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G539SILVVGGGLMF3Homo sapiens, Mus musculus, Bos taurus
G539SIQLIGGAGLT1Arabidopsis thaliana
G539SIQLVGGTAST1Oryza sativa subsp. japonica
G539SILLVGSSAKL1Drosophila melanogaster
G539CILVVGGGLLF1Danio rerio
G539SILIVGGAGQF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G539NILIVGGSSKI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G54VVIHPGSTTLR2Mus musculus, Bos taurus
G54IVIHPGSTTLR1Homo sapiens
G54VVINLGSANVR1Arabidopsis thaliana
G54VVINPGSSNVR1Oryza sativa subsp. japonica
G54IVIHPGSQHLR1Drosophila melanogaster
G54VVIHPGSRTLR1Danio rerio
G54IVLHIGSQNLR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G54IVIHPGSNSIK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G540ILVVGGGLMFH3Homo sapiens, Mus musculus, Bos taurus
G540IQLIGGAGLTK1Arabidopsis thaliana
G540IQLVGGTASTA1Oryza sativa subsp. japonica
G540ILLVGSSAKLP1Drosophila melanogaster
G540ILVVGGGLLFH1Danio rerio
G540ILIVGGAGQFP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G540ILIVGGSSKIP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G541LVVGGGLMFHK3Homo sapiens, Mus musculus, Bos taurus
G541QLIGGAGLTKG1Arabidopsis thaliana
G541QLVGGTASTAG1Oryza sativa subsp. japonica
G541LLVGSSAKLPG1Drosophila melanogaster
G541LVVGGGLLFHG1Danio rerio
G541LIVGGAGQFPG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G541LIVGGSSKIPA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K288DVGDQKTSVCC4Homo sapiens, Danio rerio, Mus musculus, Bos taurus
K288NIGAQTSTVVC1Arabidopsis thaliana
K288NIGAQVTQVVC1Oryza sativa subsp. japonica
K288DIGAQKTSIAC1Drosophila melanogaster
K288DMGAQKTSISC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K288NIGAAETRIAC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K347LLQHLKETFCH3Homo sapiens, Mus musculus, Bos taurus
K347MLNQLKESFCE1Arabidopsis thaliana
K347MLNKLKESYSQ1Oryza sativa subsp. japonica
K347LLDELKEKFCH1Drosophila melanogaster
K347LLQQLKESFCH1Danio rerio
K347LANALKIKYCG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K347LAERLKKNFTT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M543VGGGLMFHKAQ3Homo sapiens, Mus musculus, Bos taurus
M543IGGAGLTKGLV1Arabidopsis thaliana
M543VGGTASTAGLA1Oryza sativa subsp. japonica
M543VGSSAKLPGLA1Drosophila melanogaster
M543VGGGLLFHGAQ1Danio rerio
M543VGGAGQFPGFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M543VGGSSKIPALD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q287VDVGDQKTSVC4Homo sapiens, Danio rerio, Mus musculus, Bos taurus
Q287VNIGAQTSTVV1Arabidopsis thaliana
Q287VNIGAQVTQVV1Oryza sativa subsp. japonica
Q287VDIGAQKTSIA1Drosophila melanogaster
Q287VDMGAQKTSIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q287VNIGAAETRIA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q344DCLLLQHLKET3Homo sapiens, Mus musculus, Bos taurus
Q344DMLMLNQLKES1Arabidopsis thaliana
Q344DMLMLNKLKES1Oryza sativa subsp. japonica
Q344DAHLLDELKEK1Drosophila melanogaster
Q344DCVLLQQLKES1Danio rerio
Q344DWSLANALKIK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q344GWLLAERLKKN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R59GSTTLRIGRAT2Homo sapiens, Bos taurus
R59GSANVRVGLAM1Arabidopsis thaliana
R59GSSNVRIGFAS1Oryza sativa subsp. japonica
R59GSQHLRIGRAA1Drosophila melanogaster
R59GSRTLRLGRAT1Danio rerio
R59GSTTLRLGRAT1Mus musculus
R59GSQNLRIGLAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R59GSNSIKIGFPK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S55VIHPGSTTLRI2Homo sapiens, Bos taurus
S55VINLGSANVRV1Arabidopsis thaliana
S55VINPGSSNVRI1Oryza sativa subsp. japonica
S55VIHPGSQHLRI1Drosophila melanogaster
S55VIHPGSRTLRL1Danio rerio
S55VIHPGSTTLRL1Mus musculus
S55VLHIGSQNLRI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S55VIHPGSNSIKI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T56IHPGSTTLRIG2Homo sapiens, Bos taurus
T56INLGSANVRVG1Arabidopsis thaliana
T56INPGSSNVRIG1Oryza sativa subsp. japonica
T56IHPGSQHLRIG1Drosophila melanogaster
T56IHPGSRTLRLG1Danio rerio
T56IHPGSTTLRLG1Mus musculus
T56LHIGSQNLRIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T56IHPGSNSIKIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T57HPGSTTLRIGR2Homo sapiens, Bos taurus
T57NLGSANVRVGL1Arabidopsis thaliana
T57NPGSSNVRIGF1Oryza sativa subsp. japonica
T57HPGSQHLRIGR1Drosophila melanogaster
T57HPGSRTLRLGR1Danio rerio
T57HPGSTTLRLGR1Mus musculus
T57HIGSQNLRIGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T57HPGSNSIKIGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas