|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for NTN1 |
 Gene summary |
| Basic gene Info. | Gene symbol | NTN1 |
| Gene name | netrin 1 | |
| Synonyms | NTN1L | |
| Cytomap | UCSC genome browser: 17p13-p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004822.2, | |
| Description | epididymis tissue protein Li 131Pnetrin 1, mouse, homolog ofnetrin-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601614 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000065320 | ||
| HPRD : 03368 | ||
| Vega : OTTHUMG00000130257 | ||
| Protein | UniProt: O95631 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NTN1 | |
| BioGPS: 9423 | ||
| Pathway | NCI Pathway Interaction Database: NTN1 | |
| KEGG: NTN1 | ||
| REACTOME: NTN1 | ||
| Pathway Commons: NTN1 | ||
| Context | iHOP: NTN1 | |
| ligand binding site mutation search in PubMed: NTN1 | ||
| UCL Cancer Institute: NTN1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for NTN1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H381 | H381R | COAD | 1 | R348 | R348W | LUSC | 1 | D110 | D110N | STAD | 1 | G377 | T375I | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for NTN1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R348 | R348W | -1.3677364 | D110 | D110N | -0.96405173 | H381 | H381R | -0.92564875 | G377 | T375I | -0.28912846 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for NTN1 from PDB |
| Top |
| Differential gene expression and gene-gene network for NTN1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for NTN1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for NTN1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of NTN1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 4urt | A | D110 | SO4 | SULFATE | 4urt | A | G377 H381 | SO4 | SULFATE | 4urt | A | R348 |
| Top |
| Conservation information for LBS of NTN1 |
| Multiple alignments for O95631 in multiple species |
| LBS | AA sequence | # species | Species | A438 | TCNRCAKGYQQ | 4 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Gallus gallus | A438 | TCNRCARGYQQ | 1 | Drosophila melanogaster | D110 | PAFLTDLNNPH | 2 | Homo sapiens, Mus musculus | D110 | ASLLTDLNSIG | 1 | Caenorhabditis elegans | D110 | PAALTDLNNPS | 1 | Drosophila melanogaster | D110 | PSFLTDLNNPH | 1 | Gallus gallus | D209 | TDSHTDMRPLS | 2 | Homo sapiens, Mus musculus | D209 | TASHI-MGP-G | 1 | Caenorhabditis elegans | D209 | INSQHDTGG-A | 1 | Drosophila melanogaster | D209 | TDSHTDVRPLS | 1 | Gallus gallus | F107 | AHPPAFLTDLN | 2 | Homo sapiens, Mus musculus | F107 | SHPASLLTDLN | 1 | Caenorhabditis elegans | F107 | RYGPAALTDLN | 1 | Drosophila melanogaster | F107 | AHPPSFLTDLN | 1 | Gallus gallus | G377 | RHNTAGRHCHY | 3 | Homo sapiens, Mus musculus, Gallus gallus | G377 | RHNTAGRNCHL | 1 | Caenorhabditis elegans | G377 | QHDTTGRYCHY | 1 | Drosophila melanogaster | G431 | KDGVTGITCNR | 3 | Homo sapiens, Mus musculus, Gallus gallus | G431 | KPGVTGTTCNR | 1 | Caenorhabditis elegans | G431 | KEGVTGLTCNR | 1 | Drosophila melanogaster | H207 | VCTDSHTDMRP | 2 | Homo sapiens, Mus musculus | H207 | VCTASHI-MGP | 1 | Caenorhabditis elegans | H207 | RCINSQHDTGG | 1 | Drosophila melanogaster | H207 | ICTDSHTDVRP | 1 | Gallus gallus | H308 | VCDCRHNTAGP | 2 | Homo sapiens, Mus musculus | H308 | TCDCKHNTAGT | 1 | Caenorhabditis elegans | H308 | TCACKHNTAGP | 1 | Drosophila melanogaster | H308 | VCDCKHNTAGP | 1 | Gallus gallus | H381 | AGRHCHYCKEG | 3 | Homo sapiens, Mus musculus, Gallus gallus | H381 | AGRNCHLCKPG | 1 | Caenorhabditis elegans | H381 | TGRYCHYCREG | 1 | Drosophila melanogaster | I432 | DGVTGITCNRC | 3 | Homo sapiens, Mus musculus, Gallus gallus | I432 | PGVTGTTCNRC | 1 | Caenorhabditis elegans | I432 | EGVTGLTCNRC | 1 | Drosophila melanogaster | K439 | CNRCAKGYQQS | 4 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Gallus gallus | K439 | CNRCARGYQQT | 1 | Drosophila melanogaster | N112 | FLTDLNNPHNL | 3 | Homo sapiens, Mus musculus, Gallus gallus | N112 | LLTDLNSIGNM | 1 | Caenorhabditis elegans | N112 | ALTDLNNPSNV | 1 | Drosophila melanogaster | N186 | CRKMYNRPHRA | 2 | Homo sapiens, Mus musculus | N186 | CRRIFGRDPDV | 1 | Caenorhabditis elegans | N186 | CQKFYGRPDRA | 1 | Drosophila melanogaster | N186 | CRKMYNKPSRA | 1 | Gallus gallus | P188 | KMYNRPHRAPI | 2 | Homo sapiens, Mus musculus | P188 | RIFGRDPDVSI | 1 | Caenorhabditis elegans | P188 | KFYGRPDRAKI | 1 | Drosophila melanogaster | P188 | KMYNKPSRAAI | 1 | Gallus gallus | R155 | C--SPRPESMA | 3 | Homo sapiens, Mus musculus, Gallus gallus | R155 | C--SRLPDSMA | 1 | Caenorhabditis elegans | R155 | CPRSPRPDSLA | 1 | Drosophila melanogaster | R182 | YSTQCRKMYNR | 2 | Homo sapiens, Mus musculus | R182 | YSSECRRIFGR | 1 | Caenorhabditis elegans | R182 | YSSQCQKFYGR | 1 | Drosophila melanogaster | R182 | YSTQCRKMYNK | 1 | Gallus gallus | R307 | LVCDCRHNTAG | 2 | Homo sapiens, Mus musculus | R307 | YTCDCKHNTAG | 1 | Caenorhabditis elegans | R307 | MTCACKHNTAG | 1 | Drosophila melanogaster | R307 | LVCDCKHNTAG | 1 | Gallus gallus | R348 | CNLHARRCRFN | 3 | Homo sapiens, Mus musculus, Gallus gallus | R348 | CNQHAKRCRFD | 1 | Caenorhabditis elegans | R348 | CNGHARRCRFN | 1 | Drosophila melanogaster | R378 | HNTAGRHCHYC | 3 | Homo sapiens, Mus musculus, Gallus gallus | R378 | HNTAGRNCHLC | 1 | Caenorhabditis elegans | R378 | HDTTGRYCHYC | 1 | Drosophila melanogaster | R398 | KPITHRKACKA | 2 | Homo sapiens, Mus musculus | R398 | LPMTHRKACKS | 1 | Caenorhabditis elegans | R398 | KPPNHRKVCKR | 1 | Drosophila melanogaster | R398 | KPISHRKACKE | 1 | Gallus gallus | R436 | GITCNRCAKGY | 3 | Homo sapiens, Mus musculus, Gallus gallus | R436 | GTTCNRCAKGY | 1 | Caenorhabditis elegans | R436 | GLTCNRCARGY | 1 | Drosophila melanogaster | S277 | -FYAVSDLQVG | 2 | Homo sapiens, Gallus gallus | S277 | -FYSMGELAVG | 1 | Caenorhabditis elegans | S277 | QHYAVSDFAVG | 1 | Drosophila melanogaster | S277 | -YYAVSDLQVG | 1 | Mus musculus | T118 | NPHNLTCWQS- | 3 | Homo sapiens, Mus musculus, Gallus gallus | T118 | SIGNMTCWVS- | 1 | Caenorhabditis elegans | T118 | NPSNVTCWRSG | 1 | Drosophila melanogaster | T430 | CKDGVTGITCN | 3 | Homo sapiens, Mus musculus, Gallus gallus | T430 | CKPGVTGTTCN | 1 | Caenorhabditis elegans | T430 | CKEGVTGLTCN | 1 | Drosophila melanogaster |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |