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mutLBSgeneDB |
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| Gene summary for GSTO1 |
 Gene summary |
| Basic gene Info. | Gene symbol | GSTO1 |
| Gene name | glutathione S-transferase omega 1 | |
| Synonyms | GSTO 1-1|GSTTLp28|HEL-S-21|P28|SPG-R | |
| Cytomap | UCSC genome browser: 10q25.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001191002.1, NM_001191003.1,NM_004832.2, | |
| Description | GSTO-1MMA(V) reductaseS-(Phenacyl)glutathione reductaseepididymis secretory protein Li 21glutathione S-transferase omega 1-1glutathione S-transferase omega-1glutathione-S-transferase likeglutathione-dependent dehydroascorbate reductasemonomethylar | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605482 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000148834 | ||
| HPRD : 10401 | ||
| Vega : OTTHUMG00000019001 | ||
| Protein | UniProt: P78417 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GSTO1 | |
| BioGPS: 9446 | ||
| Pathway | NCI Pathway Interaction Database: GSTO1 | |
| KEGG: GSTO1 | ||
| REACTOME: GSTO1 | ||
| Pathway Commons: GSTO1 | ||
| Context | iHOP: GSTO1 | |
| ligand binding site mutation search in PubMed: GSTO1 | ||
| UCL Cancer Institute: GSTO1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 11035031 | GO:0019852 | L-ascorbic acid metabolic process | 11511179 | GO:0042178 | xenobiotic catabolic process | 12928150 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 11035031 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 11035031 | GO:0071243 | cellular response to arsenic-containing substance | 11511179 |
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| Ligand binding site mutations for GSTO1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V127 | L126F | LUSC | 1 | P33 | P33L | SKCM | 1 | E85 | E85K | UCEC | 1 | K57 | K57T | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GSTO1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V127 | L126F | -1.3709066 | E85 | E85K | -1.3520468 | K57 | K57T | -1.0477333 | P33 | P33L | -0.23463063 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GSTO1 from PDB |
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| Differential gene expression and gene-gene network for GSTO1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GSTO1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0027651 | Neoplasms | 2 | Biomarker, GeneticVariation |
| umls:C0037274 | Skin Diseases | 2 | Biomarker, GeneticVariation |
| umls:C0524851 | Neurodegenerative Diseases | 2 | Biomarker |
| umls:C0024115 | Lung Diseases | 1 | Biomarker, GeneticVariation |
| umls:C0279626 | Esophageal Squamous Cell Carcinoma | 1 | Biomarker |
| umls:C0023418 | Leukemia | 1 | Biomarker |
| umls:C0032927 | Precancerous Conditions | 1 | Biomarker |
| umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GSTO1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00143 | Glutathione | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GSTO1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ASC | ASCORBIC ACID | 3vln | A | E85 | GSH | GLUTATHIONATE(1-) | 1eem | A | P33 E85 | GSH | GLUTATHIONATE(1-) | 3lfl | A | P33 E85 | GSH | GLUTATHIONATE(1-) | 3lfl | B | P33 E85 | GSH | GLUTATHIONATE(1-) | 3lfl | C | P33 E85 | GDS | GLUTATHIONE DISULFIDE | 4is0 | A | P33 K57 E85 V127 |
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| Conservation information for LBS of GSTO1 |
| Multiple alignments for P78417 in multiple species |
| LBS | AA sequence | # species | Species | A87 | LIYESAITCEY | 1 | Homo sapiens | A87 | VVIESGFIPEY | 1 | Caenorhabditis elegans | A87 | IVIESAVIPEY | 1 | Caenorhabditis elegans | A87 | VLTESLLICEY | 1 | Drosophila melanogaster | A87 | LVTESVITCEY | 1 | Mus musculus | C32 | YSMRFCPFAQR | 2 | Drosophila melanogaster, Mus musculus | C32 | YSMRFCPFAER | 1 | Homo sapiens | C32 | YNMRFCPWAER | 1 | Caenorhabditis elegans | C32 | YNMRYCPWAQR | 1 | Caenorhabditis elegans | E85 | -QLIYESAITC | 1 | Homo sapiens | E85 | -KVVIESGFIP | 1 | Caenorhabditis elegans | E85 | KKIVIESAVIP | 1 | Caenorhabditis elegans | E85 | PPVLTESLLIC | 1 | Drosophila melanogaster | E85 | -HLVTESVITC | 1 | Mus musculus | E91 | SAITCEYLDEA | 1 | Homo sapiens | E91 | SGFIPEYLDDA | 1 | Caenorhabditis elegans | E91 | SAVIPEYLDDI | 1 | Caenorhabditis elegans | E91 | SLLICEYLDEQ | 1 | Drosophila melanogaster | E91 | SVITCEYLDEA | 1 | Mus musculus | F34 | MRFCPFAERTR | 1 | Homo sapiens | F34 | MRFCPWAERAM | 1 | Caenorhabditis elegans | F34 | MRYCPWAQRAL | 1 | Caenorhabditis elegans | F34 | MRFCPFAQRVH | 1 | Drosophila melanogaster | F34 | MRFCPFAQRTL | 1 | Mus musculus | G70 | KKNPFGLVPVL | 1 | Homo sapiens | G70 | TKHYQGKAPAV | 1 | Caenorhabditis elegans | G70 | TKHYKGQVPAL | 1 | Caenorhabditis elegans | G70 | EKNPQGKVPAL | 1 | Drosophila melanogaster | G70 | EKNPLGLVPVL | 1 | Mus musculus | K114 | EKACQKMILEL | 1 | Homo sapiens | K114 | EKVQQKLLADR | 1 | Caenorhabditis elegans | K114 | EKVQQKLLLDR | 1 | Caenorhabditis elegans | K114 | KKVQDKLLIER | 1 | Drosophila melanogaster | K114 | KKARQKMTLES | 1 | Mus musculus | K57 | ININLKNKPEW | 2 | Homo sapiens, Mus musculus | K57 | VNLNVTDKLEW | 1 | Caenorhabditis elegans | K57 | INIHLDQKPDW | 1 | Caenorhabditis elegans | K57 | IYINLTDKPEW | 1 | Drosophila melanogaster | K59 | INLKNKPEWFF | 2 | Homo sapiens, Mus musculus | K59 | LNVTDKLEWYW | 1 | Caenorhabditis elegans | K59 | IHLDQKPDWFF | 1 | Caenorhabditis elegans | K59 | INLTDKPEWLL | 1 | Drosophila melanogaster | L117 | CQKMILELFSK | 1 | Homo sapiens | L117 | QQKLLADRLTA | 1 | Caenorhabditis elegans | L117 | QQKLLLDRISG | 1 | Caenorhabditis elegans | L117 | QDKLLIERFRA | 1 | Drosophila melanogaster | L117 | RQKMTLESFSK | 1 | Mus musculus | L176 | SMIDYLIWPWF | 1 | Homo sapiens | L176 | GYPDYLSFPFF | 1 | Caenorhabditis elegans | L176 | GFVDYLIYPNI | 1 | Caenorhabditis elegans | L176 | GILDYMIWPWC | 1 | Drosophila melanogaster | L176 | SMVDYLTWPWF | 1 | Mus musculus | L228 | QGFLELYLQNS | 1 | Homo sapiens | L228 | AAFMNAYATHQ | 1 | Caenorhabditis elegans | L228 | VEFFKSWIIGA | 1 | Caenorhabditis elegans | L228 | AEFLRTRSLGR | 1 | Drosophila melanogaster | L228 | REYLNLYLQDS | 1 | Mus musculus | L56 | VININLKNKPE | 2 | Homo sapiens, Mus musculus | L56 | VVNLNVTDKLE | 1 | Caenorhabditis elegans | L56 | VINIHLDQKPD | 1 | Caenorhabditis elegans | L56 | SIYINLTDKPE | 1 | Drosophila melanogaster | L71 | KNPFGLVPVLE | 1 | Homo sapiens | L71 | KHYQGKAPAVE | 1 | Caenorhabditis elegans | L71 | KHYKGQVPALE | 1 | Caenorhabditis elegans | L71 | KNPQGKVPALE | 1 | Drosophila melanogaster | L71 | KNPLGLVPVLE | 1 | Mus musculus | M172 | -NSISMIDYLI | 1 | Homo sapiens | M172 | -SQPGYPDYLS | 1 | Caenorhabditis elegans | M172 | TSKPGFVDYLI | 1 | Caenorhabditis elegans | M172 | -EQTGILDYMI | 1 | Drosophila melanogaster | M172 | -DSPSMVDYLT | 1 | Mus musculus | P33 | SMRFCPFAERT | 1 | Homo sapiens | P33 | NMRFCPWAERA | 1 | Caenorhabditis elegans | P33 | NMRYCPWAQRA | 1 | Caenorhabditis elegans | P33 | SMRFCPFAQRV | 1 | Drosophila melanogaster | P33 | SMRFCPFAQRT | 1 | Mus musculus | P73 | PFGLVPVLE-- | 1 | Homo sapiens | P73 | YQGKAPAVE-- | 1 | Caenorhabditis elegans | P73 | YKGQVPALE-- | 1 | Caenorhabditis elegans | P73 | PQGKVPALEIV | 1 | Drosophila melanogaster | P73 | PLGLVPVLE-- | 1 | Mus musculus | R37 | CPFAERTRLVL | 1 | Homo sapiens | R37 | CPWAERAMLYV | 1 | Caenorhabditis elegans | R37 | CPWAQRALIFA | 1 | Caenorhabditis elegans | R37 | CPFAQRVHLVL | 1 | Drosophila melanogaster | R37 | CPFAQRTLMVL | 1 | Mus musculus | S121 | ILELFSKVPSL | 1 | Homo sapiens | S121 | LADRLTAVAHA | 1 | Caenorhabditis elegans | S121 | LLDRISG--QL | 1 | Caenorhabditis elegans | S121 | LIERFRA---V | 1 | Drosophila melanogaster | S121 | TLESFSKVPPL | 1 | Mus musculus | S86 | QLIYESAITCE | 1 | Homo sapiens | S86 | KVVIESGFIPE | 1 | Caenorhabditis elegans | S86 | KIVIESAVIPE | 1 | Caenorhabditis elegans | S86 | PVLTESLLICE | 1 | Drosophila melanogaster | S86 | HLVTESVITCE | 1 | Mus musculus | V127 | KVPSLVGSFIR | 1 | Homo sapiens | V127 | AVAHAVPLLFA | 1 | Caenorhabditis elegans | V127 | G--QLSSAFYG | 1 | Caenorhabditis elegans | V127 | A---VLGAFFK | 1 | Drosophila melanogaster | V127 | KVPPLIASFVR | 1 | Mus musculus | V72 | NPFGLVPVLE- | 1 | Homo sapiens | V72 | HYQGKAPAVE- | 1 | Caenorhabditis elegans | V72 | HYKGQVPALE- | 1 | Caenorhabditis elegans | V72 | NPQGKVPALEI | 1 | Drosophila melanogaster | V72 | NPLGLVPVLE- | 1 | Mus musculus | W222 | TSEKDWQGFLE | 1 | Homo sapiens | W222 | QSLEHGAAFMN | 1 | Caenorhabditis elegans | W222 | QPTETAVEFFK | 1 | Caenorhabditis elegans | W222 | MEAEVQAEFLR | 1 | Drosophila melanogaster | W222 | IDAKTYREYLN | 1 | Mus musculus | Y229 | GFLELYLQNSP | 1 | Homo sapiens | Y229 | AFMNAYATHQE | 1 | Caenorhabditis elegans | Y229 | EFFKSWIIGAP | 1 | Caenorhabditis elegans | Y229 | EFLRTRSLGRP | 1 | Drosophila melanogaster | Y229 | EYLNLYLQDSP | 1 | Mus musculus |
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