mutLBSgeneDB |
Gene summary for MAP4K4 |
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Basic gene Info. | Gene symbol | MAP4K4 |
Gene name | mitogen-activated protein kinase kinase kinase kinase 4 | |
Synonyms | FLH21957|HEL-S-31|HGK|MEKKK4|NIK | |
Cytomap | UCSC genome browser: 2q11.2-q12 | |
Type of gene | protein-coding | |
RefGenes | NM_001242559.1, NM_001242560.1,NM_004834.4,NM_145686.3,NM_145687.3, | |
Description | HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase-like kinasenck-interacting kinase | |
Modification date | 20141207 | |
dbXrefs | MIM : 604666 | |
HGNC : HGNC | ||
Ensembl : ENSG00000071054 | ||
HPRD : 05235 | ||
Vega : OTTHUMG00000155394 | ||
Protein | UniProt: O95819 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MAP4K4 | |
BioGPS: 9448 | ||
Pathway | NCI Pathway Interaction Database: MAP4K4 | |
KEGG: MAP4K4 | ||
REACTOME: MAP4K4 | ||
Pathway Commons: MAP4K4 | ||
Context | iHOP: MAP4K4 | |
ligand binding site mutation search in PubMed: MAP4K4 | ||
UCL Cancer Institute: MAP4K4 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 9890973 | GO:0035556 | intracellular signal transduction | 9890973 | GO:0046328 | regulation of JNK cascade | 14966141 |
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Ligand binding site mutations for MAP4K4 |
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LBS | AAchange of nsSNV | Cancer type | # samples | I82,R80 | N81H | COAD | 1 | S77 | Y76F | GBM | 1 | D153 | R152G | SKCM | 1 | V31 | V30A | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MAP4K4 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | V31 | V30A | -1.8207955 | D153 | R152G | -1.321913 | I82 | N81H | -0.94852495 | R80 | N81H | -0.94852495 | S77 | Y76F | -0.85392353 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for MAP4K4 |
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Phenotype information for MAP4K4 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MAP4K4 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ANP | AMP-PNP | 4u40 | A | D153 | MG | MAGNESIUM(2+) | 4obp | A | S77 I82 | MG | MAGNESIUM(2+) | 4obq | A | S77 I82 | MG | MAGNESIUM(2+) | 4u45 | A | S77 I82 | MG | MAGNESIUM(2+) | 4zk5 | A | S77 I82 | MG | MAGNESIUM(2+) | 4u40 | A | S77 I82 | MG | MAGNESIUM(2+) | 4u41 | A | S77 I82 | MG | MAGNESIUM(2+) | 4u42 | B | S77 I82 | MG | MAGNESIUM(2+) | 4u42 | A | S77 R80 I82 | 2QV | 6-(3-CHLOROPHENYL)QUINAZOLIN-4-AMINE | 4obo | A | V31 | 2QU | 6-(2-FLUOROPYRIDIN-4-YL)PYRIDO[3,2-D]PYRIMIDIN-4-AMINE | 4obp | A | V31 | 3D8 | N-(PYRIDIN-3-YL)PYRROLO[2,1-F][1,2,4]TRIAZIN-4-AMINE | 4u43 | A | V31 | 3D9 | 6-PHENYL-N-(PYRIDIN-4-YL)PYRROLO[2,1-F][1,2,4]TRIAZIN- 4-AMINE | 4u44 | A | V31 | 3DC | 6-(1H-PYRAZOL-4-YL)-N-(PYRIDIN-4-YL)PYRROLO[2,1-F][1,2, 4]TRIAZIN-4-AMINE | 4u45 | A | V31 | 3XM | 3-HEXANOYL-4-HYDROXY-5-(4-HYDROXYPHENYL)PYRIDIN-2(1H)- ONE | 4rvt | A | V31 | 4P4 | GNE-495 | 8-AMINO-N-[1-(CYCLOPROPYLCARBONYL)AZETIDIN-3-YL]-2-(3- FLUOROPHENYL)-1,7-NAPHTHYRIDINE-5-CARBOXAMIDE | 4zk5 | A | V31 | 5DF | 4-{6-AMINO-5-[4-(METHYLSULFONYL)PHENYL]PYRIDIN-3- YL}PHENOL | 5di1 | A | V31 |
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Conservation information for LBS of MAP4K4 |
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LBS | AA sequence | # species | Species |
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