mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for EIF4E2
Gene summary
Basic gene Info.Gene symbolEIF4E2
Gene nameeukaryotic translation initiation factor 4E family member 2
CytomapUCSC genome browser: 2q37.1
Type of geneprotein-coding
DescriptioneIF-4E type 2eIF4E-like cap-binding proteineIF4E-like protein 4E-LPeukaryotic translation initiation factor 4E homologous proteineukaryotic translation initiation factor 4E type 2eukaryotic translation initiation factor 4E-like 3mRNA cap-binding pro
Modification date20141207
dbXrefs MIM : 605895
Ensembl : ENSG00000135930
HPRD : 05798
Vega : OTTHUMG00000133256
ProteinUniProt: O60573
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_EIF4E2
BioGPS: 9470
PathwayNCI Pathway Interaction Database: EIF4E2
Pathway Commons: EIF4E2
ContextiHOP: EIF4E2
ligand binding site mutation search in PubMed: EIF4E2
UCL Cancer Institute: EIF4E2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for EIF4E2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for EIF4E2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for EIF4E2 from PDB

Differential gene expression and gene-gene network for EIF4E2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of EIF4E2 and the right PPI network was created from samples without mutations in the LBS of EIF4E2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for EIF4E2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for EIF4E2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of EIF4E2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of EIF4E2
Multiple alignments for O60573 in multiple species
LBSAA sequence# speciesSpecies
E125IKPMWEDDANK2Homo sapiens, Mus musculus
E125VKPVWEDPANC1Caenorhabditis elegans
E149ASRCWENLILA2Homo sapiens, Mus musculus
E149STRIWENLLMA1Caenorhabditis elegans
E158LAMLGEQFMVG2Homo sapiens, Mus musculus
E158MAIIGEQFLVG1Caenorhabditis elegans
E164QFMVGEEICGA2Homo sapiens, Mus musculus
E164QFLVGDELCGA1Caenorhabditis elegans
E92TFASVEQFWRF1Homo sapiens
E92TFASVEQFWKF1Mus musculus
E92IMKSVEQFWSI1Caenorhabditis elegans
F53Homo sapiens, Mus musculus, Caenorhabditis elegans
G157ILAMLGEQFMV2Homo sapiens, Mus musculus
G157LMAIIGEQFLV1Caenorhabditis elegans
G163EQFMVGEEICG2Homo sapiens, Mus musculus
G163EQFLVGDELCG1Caenorhabditis elegans
H110GDLTGHSDFHL2Homo sapiens, Mus musculus
H110TEMCDKADIHF1Caenorhabditis elegans
H54PGPAEHPLQYN2Homo sapiens, Mus musculus
H54-GSDDHQLQYS1Caenorhabditis elegans
L153WENLILAMLGE2Homo sapiens, Mus musculus
L153WENLLMAIIGE1Caenorhabditis elegans
M123EGIKPMWEDDA2Homo sapiens, Mus musculus
M123TGVKPVWEDPA1Caenorhabditis elegans
M161LGEQFMVGEEI2Homo sapiens, Mus musculus
M161IGEQFLVGDEL1Caenorhabditis elegans
N150SRCWENLILAM2Homo sapiens, Mus musculus
N150TRIWENLLMAI1Caenorhabditis elegans
P55GPAEHPLQYNY2Homo sapiens, Mus musculus
P55GSDDHQLQYSY1Caenorhabditis elegans
Q159AMLGEQFMVGE2Homo sapiens, Mus musculus
Q159AIIGEQFLVGD1Caenorhabditis elegans
Q57AEHPLQYNYTF2Homo sapiens, Mus musculus
Q57DDHQLQYSYTF1Caenorhabditis elegans
R174AVVSVRFQEDI2Homo sapiens, Mus musculus
R174AVCSIRNQEDI1Caenorhabditis elegans
R67FWYSRRTPGRP2Homo sapiens, Mus musculus
R67FSYFMRPTGK-1Caenorhabditis elegans
T73TPGRPTSSQSY2Homo sapiens, Mus musculus
T73PTGK-FDPEDY1Caenorhabditis elegans
V91GTFASVEQFWR1Homo sapiens
V91GTFASVEQFWK1Mus musculus
V91GIMKSVEQFWS1Caenorhabditis elegans
W124GIKPMWEDDAN2Homo sapiens, Mus musculus
W124GVKPVWEDPAN1Caenorhabditis elegans
W95SVEQFWRFYSH1Homo sapiens
W95SVEQFWKFYSH1Mus musculus
W95SVEQFWSIMVH1Caenorhabditis elegans
Y58EHPLQYNYTFW2Homo sapiens, Mus musculus
Y58DHQLQYSYTFS1Caenorhabditis elegans
Y78TSSQSYEQNIK2Homo sapiens, Mus musculus
Y78FDPEDYASYVQ1Caenorhabditis elegans

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