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mutLBSgeneDB |
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| Gene summary for ROCK2 |
 Gene summary |
| Basic gene Info. | Gene symbol | ROCK2 |
| Gene name | Rho-associated, coiled-coil containing protein kinase 2 | |
| Synonyms | ROCK-II | |
| Cytomap | UCSC genome browser: 2p24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004850.3, | |
| Description | p164 ROCK-2rho-associated protein kinase 2rho-associated, coiled-coil-containing protein kinase II | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604002 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000134318 | ||
| HPRD : 04922 | ||
| Vega : OTTHUMG00000149916 | ||
| Protein | UniProt: O75116 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ROCK2 | |
| BioGPS: 9475 | ||
| Pathway | NCI Pathway Interaction Database: ROCK2 | |
| KEGG: ROCK2 | ||
| REACTOME: ROCK2 | ||
| Pathway Commons: ROCK2 | ||
| Context | iHOP: ROCK2 | |
| ligand binding site mutation search in PubMed: ROCK2 | ||
| UCL Cancer Institute: ROCK2 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 18559669 |
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| Ligand binding site mutations for ROCK2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E170 | E170A | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ROCK2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E170 | E170A | -1.1669238 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ROCK2 from PDB |
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| Differential gene expression and gene-gene network for ROCK2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ROCK2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0086468 | Prenatal Injuries | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ROCK2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB08162 | 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE | Small molecule |  |
| Experimental | DB08756 | (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ROCK2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 1WU | 6-[4-(AMINOMETHYL)-2-FLUOROPHENOXY]-2,1-BENZOXABOROL- 1(3H)-OL | 6-[4-(AMINOMETHYL)-2-FLUOROPHENOXY]BENZO[C][1, 2]OXABOROL-1(3H)-OL | 4l6q | A | E170 | 1WU | 6-[4-(AMINOMETHYL)-2-FLUOROPHENOXY]-2,1-BENZOXABOROL- 1(3H)-OL | 6-[4-(AMINOMETHYL)-2-FLUOROPHENOXY]BENZO[C][1, 2]OXABOROL-1(3H)-OL | 4l6q | B | E170 | 3SG | METHYL 3-[({2'-(AMINOMETHYL)-5'-[(3-FLUOROPYRIDIN-4- YL)CARBAMOYL]BIPHENYL-3-YL}CARBONYL)AMINO]-4- FLUOROBENZOATE | 4wot | A | E170 | 3SG | METHYL 3-[({2'-(AMINOMETHYL)-5'-[(3-FLUOROPYRIDIN-4- YL)CARBAMOYL]BIPHENYL-3-YL}CARBONYL)AMINO]-4- FLUOROBENZOATE | 4wot | B | E170 | 3SG | METHYL 3-[({2'-(AMINOMETHYL)-5'-[(3-FLUOROPYRIDIN-4- YL)CARBAMOYL]BIPHENYL-3-YL}CARBONYL)AMINO]-4- FLUOROBENZOATE | 4wot | C | E170 | 3SG | METHYL 3-[({2'-(AMINOMETHYL)-5'-[(3-FLUOROPYRIDIN-4- YL)CARBAMOYL]BIPHENYL-3-YL}CARBONYL)AMINO]-4- FLUOROBENZOATE | 4wot | D | E170 |
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| Conservation information for LBS of ROCK2 |
| Multiple alignments for O75116 in multiple species |
| LBS | AA sequence | # species | Species | A102 | VIGRGAFGEVQ | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A102 | VIGRGAFGEVH | 1 | Caenorhabditis elegans | A119 | SQKVYAMKLLS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A119 | TNTVYAMKMLN | 1 | Caenorhabditis elegans | A231 | GHLKLADFGTC | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A231 | GHIKLADFGTC | 1 | Caenorhabditis elegans | D214 | GLIHRDVKPDN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D214 | GYIHRDVKPDN | 1 | Caenorhabditis elegans | D218 | RDVKPDNMLLD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D218 | RDVKPDNMLIS | 1 | Caenorhabditis elegans | D232 | HLKLADFGTCM | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D232 | HIKLADFGTCV | 1 | Caenorhabditis elegans | E170 | LYMVMEYMPGG | 5 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus | F103 | IGRGAFGEVQL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | F103 | IGRGAFGEVHL | 1 | Caenorhabditis elegans | F136 | RSDSAFFWEER | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | F136 | RADSAFFWEER | 1 | Caenorhabditis elegans | F384 | IDSSNFDDIED | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | F384 | DDTTHFEEIET | 1 | Caenorhabditis elegans | G101 | KVIGRGAFGEV | 5 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus | G104 | GRGAFGEVQLV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G104 | GRGAFGEVHLV | 1 | Caenorhabditis elegans | I98 | DVVKVIGRGAF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I98 | RQLKVIGRGAF | 1 | Caenorhabditis elegans | K121 | KVYAMKLLSKF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K121 | TVYAMKMLNKD | 1 | Caenorhabditis elegans | L123 | YAMKLLSKFEM | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L123 | YAMKMLNKDDM | 1 | Caenorhabditis elegans | L221 | KPDNMLLDKHG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L221 | KPDNMLISISG | 1 | Caenorhabditis elegans | M169 | YLYMVMEYMPG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | M169 | HLYMVMEYMPG | 1 | Caenorhabditis elegans | M172 | MVMEYMPGGDL | 5 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus | N219 | DVKPDNMLLDK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | N219 | DVKPDNMLISI | 1 | Caenorhabditis elegans | T235 | LADFGTCMKMD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T235 | LADFGTCVKMN | 1 | Caenorhabditis elegans | V106 | GAFGEVQLVRH | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | V106 | GAFGEVHLVRH | 1 | Caenorhabditis elegans | V153 | NSPWVVQLFCA | 3 | Mus musculus, Rattus norvegicus, Bos taurus | V153 | NSPWVVQLFYA | 1 | Homo sapiens | V153 | NSEWIVRLQYA | 1 | Caenorhabditis elegans | V251 | HCDTAVGTPDY | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | V251 | RCSTAVGTPDY | 1 | Caenorhabditis elegans | Y171 | YMVMEYMPGGD | 5 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus |
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