mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ROCK2
Gene summary
Basic gene Info.Gene symbolROCK2
Gene nameRho-associated, coiled-coil containing protein kinase 2
SynonymsROCK-II
CytomapUCSC genome browser: 2p24
Type of geneprotein-coding
RefGenesNM_004850.3,
Descriptionp164 ROCK-2rho-associated protein kinase 2rho-associated, coiled-coil-containing protein kinase II
Modification date20141207
dbXrefs MIM : 604002
HGNC : HGNC
Ensembl : ENSG00000134318
HPRD : 04922
Vega : OTTHUMG00000149916
ProteinUniProt: O75116
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ROCK2
BioGPS: 9475
PathwayNCI Pathway Interaction Database: ROCK2
KEGG: ROCK2
REACTOME: ROCK2
Pathway Commons: ROCK2
ContextiHOP: ROCK2
ligand binding site mutation search in PubMed: ROCK2
UCL Cancer Institute: ROCK2
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006468protein phosphorylation18559669


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Ligand binding site mutations for ROCK2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E170E170AUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ROCK2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
E170E170A-1.1669238
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ROCK2 from PDB

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Differential gene expression and gene-gene network for ROCK2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ROCK2 and the right PPI network was created from samples without mutations in the LBS of ROCK2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ROCK2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0086468Prenatal Injuries1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ROCK2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB081625-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINESmall molecule
ExperimentalDB08756(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ROCK2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
1WU6-[4-(AMINOMETHYL)-2-FLUOROPHENOXY]-2,1-BENZOXABOROL- 1(3H)-OL6-[4-(AMINOMETHYL)-2-FLUOROPHENOXY]BENZO[C][1, 2]OXABOROL-1(3H)-OL4l6qAE170
1WU6-[4-(AMINOMETHYL)-2-FLUOROPHENOXY]-2,1-BENZOXABOROL- 1(3H)-OL6-[4-(AMINOMETHYL)-2-FLUOROPHENOXY]BENZO[C][1, 2]OXABOROL-1(3H)-OL4l6qBE170
3SGMETHYL 3-[({2'-(AMINOMETHYL)-5'-[(3-FLUOROPYRIDIN-4- YL)CARBAMOYL]BIPHENYL-3-YL}CARBONYL)AMINO]-4- FLUOROBENZOATE4wotAE170
3SGMETHYL 3-[({2'-(AMINOMETHYL)-5'-[(3-FLUOROPYRIDIN-4- YL)CARBAMOYL]BIPHENYL-3-YL}CARBONYL)AMINO]-4- FLUOROBENZOATE4wotBE170
3SGMETHYL 3-[({2'-(AMINOMETHYL)-5'-[(3-FLUOROPYRIDIN-4- YL)CARBAMOYL]BIPHENYL-3-YL}CARBONYL)AMINO]-4- FLUOROBENZOATE4wotCE170
3SGMETHYL 3-[({2'-(AMINOMETHYL)-5'-[(3-FLUOROPYRIDIN-4- YL)CARBAMOYL]BIPHENYL-3-YL}CARBONYL)AMINO]-4- FLUOROBENZOATE4wotDE170


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Conservation information for LBS of ROCK2
Multiple alignments for O75116 in multiple species
LBSAA sequence# speciesSpecies
A102VIGRGAFGEVQ4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A102VIGRGAFGEVH1Caenorhabditis elegans
A119SQKVYAMKLLS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A119TNTVYAMKMLN1Caenorhabditis elegans
A231GHLKLADFGTC4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A231GHIKLADFGTC1Caenorhabditis elegans
D214GLIHRDVKPDN4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D214GYIHRDVKPDN1Caenorhabditis elegans
D218RDVKPDNMLLD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D218RDVKPDNMLIS1Caenorhabditis elegans
D232HLKLADFGTCM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D232HIKLADFGTCV1Caenorhabditis elegans
E170LYMVMEYMPGG5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
F103IGRGAFGEVQL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F103IGRGAFGEVHL1Caenorhabditis elegans
F136RSDSAFFWEER4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F136RADSAFFWEER1Caenorhabditis elegans
F384IDSSNFDDIED4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F384DDTTHFEEIET1Caenorhabditis elegans
G101KVIGRGAFGEV5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
G104GRGAFGEVQLV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G104GRGAFGEVHLV1Caenorhabditis elegans
I98DVVKVIGRGAF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I98RQLKVIGRGAF1Caenorhabditis elegans
K121KVYAMKLLSKF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K121TVYAMKMLNKD1Caenorhabditis elegans
L123YAMKLLSKFEM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L123YAMKMLNKDDM1Caenorhabditis elegans
L221KPDNMLLDKHG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L221KPDNMLISISG1Caenorhabditis elegans
M169YLYMVMEYMPG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M169HLYMVMEYMPG1Caenorhabditis elegans
M172MVMEYMPGGDL5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
N219DVKPDNMLLDK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N219DVKPDNMLISI1Caenorhabditis elegans
T235LADFGTCMKMD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T235LADFGTCVKMN1Caenorhabditis elegans
V106GAFGEVQLVRH4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V106GAFGEVHLVRH1Caenorhabditis elegans
V153NSPWVVQLFCA3Mus musculus, Rattus norvegicus, Bos taurus
V153NSPWVVQLFYA1Homo sapiens
V153NSEWIVRLQYA1Caenorhabditis elegans
V251HCDTAVGTPDY4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V251RCSTAVGTPDY1Caenorhabditis elegans
Y171YMVMEYMPGGD5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus


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