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mutLBSgeneDB |
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| Gene summary for PTGES |
 Gene summary |
| Basic gene Info. | Gene symbol | PTGES |
| Gene name | prostaglandin E synthase | |
| Synonyms | MGST-IV|MGST1-L1|MGST1L1|MPGES|PGES|PIG12|PP102|PP1294|TP53I12|mPGES-1 | |
| Cytomap | UCSC genome browser: 9q34.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004878.4, NM_198797.1, | |
| Description | MGST1-like 1glutathione S-transferase 1-like 1microsomal glutathione S-transferase 1-like 1microsomal prostaglandin E synthase 1microsomal prostaglandin E synthase-1p53-induced apoptosis protein 12p53-induced gene 12 proteintumor protein p53 induci | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605172 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000148344 | ||
| HPRD : 05528 | ||
| Vega : OTTHUMG00000020791 | ||
| Protein | UniProt: O14684 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PTGES | |
| BioGPS: 9536 | ||
| Pathway | NCI Pathway Interaction Database: PTGES | |
| KEGG: PTGES | ||
| REACTOME: PTGES | ||
| Pathway Commons: PTGES | ||
| Context | iHOP: PTGES | |
| ligand binding site mutation search in PubMed: PTGES | ||
| UCL Cancer Institute: PTGES | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0001516 | prostaglandin biosynthetic process | 18682561 |
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| Ligand binding site mutations for PTGES |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A123 | R122Q | UCEC | 1 | R126,P124 | I125T | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PTGES |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | A123 | R122Q | -1.0613377 | P124 | I125T | -0.64149801 | R126 | I125T | -0.64149801 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PTGES from PDB |
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| Differential gene expression and gene-gene network for PTGES |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PTGES |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0020295 | Hydronephrosis | 2 | Biomarker |
| umls:C0032617 | Polyuria | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PTGES |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PTGES go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | LVJ | 2-[[2,6-BIS(CHLORANYL)-3-[(2,2- DIMETHYLPROPANOYLAMINO)METHYL]PHENYL]AMINO]-1-METHYL-6 METHYL-2-OXIDANYL-PROPOXY)-N-[2,2,2- TRIS(FLUORANYL)ETHYL]BENZIMIDAZOLE-5- CARBOXAMIDE | 4bpm | A | A123 P124 | 4DZ | 2-(9-CHLORO-1H-PHENANTHRO[9,10-D]IMIDAZOL-2-YL)BENZENE- 1,3-DICARBONITRILE | 4yl0 | A | A123 P124 | 4U8 | 5-(4-TERT-BUTYLPHENYL)-1-[4-(PROPAN-2-YLOXY)PHENYL]-1H- INDOLE-2-CARBOXYLIC ACID | 4yl1 | A | P124 | 4U9 | 5-[4-BROMO-2-(2-CHLORO-6-FLUOROPHENYL)-1H-IMIDAZOL-5- YL]-2-{[4-(TRIFLUOROMETHYL)PHENYL]ETHYNYL}PYRIDINE | 4yl3 | A | P124 | 4DV | 3-[1-(4-CHLOROBENZYL)-5-(2-FLUORO-2'-METHYLBIPHENYL-4- YL)-3-METHYL-1H-INDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID | 4yk5 | A | P124 | GSH | GLUTATHIONATE(1-) | 3dww | A | R126 | GSH | GLUTATHIONATE(1-) | 3dww | B | R126 | GSH | GLUTATHIONATE(1-) | 3dww | C | R126 | GSH | GLUTATHIONATE(1-) | 4al0 | A | R126 | 48T | L-GAMMA-GLUTAMYL-S-(2-BIPHENYL-4-YL-2- OXOETHYL)-L-CYSTEINYLGLYCINE | 4al1 | A | R126 | GSH | GLUTATHIONATE(1-) | 4bpm | A | R126 | GSH | GLUTATHIONATE(1-) | 4yl0 | A | R126 | GSH | GLUTATHIONATE(1-) | 4yl1 | A | R126 | GSH | GLUTATHIONATE(1-) | 4yl3 | A | R126 | GSH | GLUTATHIONATE(1-) | 4yk5 | A | R126 |
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| Conservation information for LBS of PTGES |
| Multiple alignments for O14684 in multiple species |
| LBS | AA sequence | # species | Species | A123 | LGKLRAPTRSL | 2 | Canis lupus familiaris, Bos taurus | A123 | LGKLRAPIRSV | 1 | Homo sapiens | A123 | LGKLNPRLRSG | 1 | Mus musculus | A138 | AQLPCASMALQ | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | A138 | AQFSCFSMALQ | 1 | Mus musculus | A31 | KMYVVAVITGQ | 2 | Canis lupus familiaris, Bos taurus | A31 | KMYVVAIITGQ | 1 | Homo sapiens | A31 | KMYAVAVITGQ | 1 | Mus musculus | C68 | PDVERCLRAHR | 3 | Homo sapiens, Mus musculus, Bos taurus | C68 | QDVDRCLRAHR | 1 | Canis lupus familiaris | E77 | HRNDMETIYPF | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | G35 | VAVITGQVRLR | 2 | Canis lupus familiaris, Bos taurus | G35 | VAIITGQVRLR | 1 | Homo sapiens | G35 | VAVITGQMRLR | 1 | Mus musculus | H113 | LGRMVHTVAYL | 2 | Canis lupus familiaris, Bos taurus | H113 | VGRVAHTVAYL | 1 | Homo sapiens | H113 | TGRVVHTVAYL | 1 | Mus musculus | H72 | RCLRAHRNDME | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | L132 | SVTYTLAQLPC | 1 | Homo sapiens | L132 | SGAYVLAQFSC | 1 | Mus musculus | L132 | SLAYTVAQLPC | 1 | Canis lupus familiaris | L132 | SLAYTLAQLPC | 1 | Bos taurus | L135 | YTLAQLPCASM | 2 | Homo sapiens, Bos taurus | L135 | YVLAQFSCFSM | 1 | Mus musculus | L135 | YTVAQLPCASM | 1 | Canis lupus familiaris | N74 | LRAHRNDMETI | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | P124 | GKLRAPTRSLA | 2 | Canis lupus familiaris, Bos taurus | P124 | GKLRAPIRSVT | 1 | Homo sapiens | P124 | GKLNPRLRSGA | 1 | Mus musculus | Q134 | TYTLAQLPCAS | 1 | Homo sapiens | Q134 | AYVLAQFSCFS | 1 | Mus musculus | Q134 | AYTVAQLPCAS | 1 | Canis lupus familiaris | Q134 | AYTLAQLPCAS | 1 | Bos taurus | Q143 | ASMALQIVWEA | 2 | Canis lupus familiaris, Bos taurus | Q143 | ASMALQILWEA | 1 | Homo sapiens | Q143 | FSMALQILWEV | 1 | Mus musculus | R110 | VFFLGRMVHTV | 2 | Canis lupus familiaris, Bos taurus | R110 | VFLVGRVAHTV | 1 | Homo sapiens | R110 | VVLTGRVVHTV | 1 | Mus musculus | R126 | LRAPTRSLAYT | 2 | Canis lupus familiaris, Bos taurus | R126 | LRAPIRSVTYT | 1 | Homo sapiens | R126 | LNPRLRSGAYV | 1 | Mus musculus | R38 | ITGQVRLRKKA | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | R38 | ITGQMRLRKKA | 1 | Mus musculus | R70 | VERCLRAHRND | 3 | Homo sapiens, Mus musculus, Bos taurus | R70 | VDRCLRAHRND | 1 | Canis lupus familiaris | R73 | CLRAHRNDMET | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | S127 | RAPIRSVTYTL | 1 | Homo sapiens | S127 | NPRLRSGAYVL | 1 | Mus musculus | S127 | RAPTRSLAYTV | 1 | Canis lupus familiaris | S127 | RAPTRSLAYTL | 1 | Bos taurus | S139 | QLPCASMALQI | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | S139 | QFSCFSMALQI | 1 | Mus musculus | T131 | RSVTYTLAQLP | 1 | Homo sapiens | T131 | RSGAYVLAQFS | 1 | Mus musculus | T131 | RSLAYTVAQLP | 1 | Canis lupus familiaris | T131 | RSLAYTLAQLP | 1 | Bos taurus | T34 | VVAVITGQVRL | 2 | Canis lupus familiaris, Bos taurus | T34 | VVAIITGQVRL | 1 | Homo sapiens | T34 | AVAVITGQMRL | 1 | Mus musculus | V128 | APIRSVTYTLA | 1 | Homo sapiens | V128 | PRLRSGAYVLA | 1 | Mus musculus | V128 | APTRSLAYTVA | 1 | Canis lupus familiaris | V128 | APTRSLAYTLA | 1 | Bos taurus | W146 | ALQILWEAARH | 1 | Homo sapiens | W146 | ALQILWEVAHH | 1 | Mus musculus | W146 | ALQIVWEAACH | 1 | Canis lupus familiaris | W146 | ALQIVWEAARH | 1 | Bos taurus | Y117 | VHTVAYLGKLR | 2 | Canis lupus familiaris, Bos taurus | Y117 | AHTVAYLGKLR | 1 | Homo sapiens | Y117 | VHTVAYLGKLN | 1 | Mus musculus | Y130 | IRSVTYTLAQL | 1 | Homo sapiens | Y130 | LRSGAYVLAQF | 1 | Mus musculus | Y130 | TRSLAYTVAQL | 1 | Canis lupus familiaris | Y130 | TRSLAYTLAQL | 1 | Bos taurus | Y28 | LVIKMYVVAVI | 2 | Canis lupus familiaris, Bos taurus | Y28 | LVIKMYVVAII | 1 | Homo sapiens | Y28 | LVIKMYAVAVI | 1 | Mus musculus |
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