mutLBSgeneDB |
Gene summary for TP53I3 |
![]() |
Basic gene Info. | Gene symbol | TP53I3 |
Gene name | tumor protein p53 inducible protein 3 | |
Synonyms | PIG3 | |
Cytomap | UCSC genome browser: 2p23.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001206802.2, NM_004881.4,NM_147184.3, | |
Description | p53-induced gene 3 proteinquinone oxidoreductase PIG3quinone oxidoreductase homolog | |
Modification date | 20141207 | |
dbXrefs | MIM : 605171 | |
HGNC : HGNC | ||
Ensembl : ENSG00000115129 | ||
HPRD : 05527 | ||
Vega : OTTHUMG00000090817 | ||
Protein | UniProt: Q53FA7 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TP53I3 | |
BioGPS: 9540 | ||
Pathway | NCI Pathway Interaction Database: TP53I3 | |
KEGG: TP53I3 | ||
REACTOME: TP53I3 | ||
Pathway Commons: TP53I3 | ||
Context | iHOP: TP53I3 | |
ligand binding site mutation search in PubMed: TP53I3 | ||
UCL Cancer Institute: TP53I3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID | GO:0006739 | NADP metabolic process | 19349281 |
Top |
Ligand binding site mutations for TP53I3 |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | I217,Y221 | G219R | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for TP53I3 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | I217 | G219R | -0.8440513 | Y221 | G219R | -0.8440513 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for TP53I3 |
![]() |
![]() |
Top |
Top |
Phenotype information for TP53I3 |
![]() |
Disease ID | Disease name | # PubMed | Association type |
umls:C0007097 | Carcinoma | 2 | Biomarker |
umls:C0024667 | Mammary Neoplasms, Animal | 1 | Biomarker |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for TP53I3 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NAP | NADP ZWITTERION | 2oby | B | I217 | NAP | NADP ZWITTERION | 2oby | A | I217 Y221 | NAP | NADP ZWITTERION | 2oby | C | I217 Y221 | NAP | NADP ZWITTERION | 2oby | E | I217 Y221 | NAP | NADP ZWITTERION | 2oby | D | Y221 |
Top |
Conservation information for LBS of TP53I3 |
![]() |
LBS | AA sequence | # species | Species |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |