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mutLBSgeneDB |
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| Gene summary for TP53I3 |
 Gene summary |
| Basic gene Info. | Gene symbol | TP53I3 |
| Gene name | tumor protein p53 inducible protein 3 | |
| Synonyms | PIG3 | |
| Cytomap | UCSC genome browser: 2p23.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001206802.2, NM_004881.4,NM_147184.3, | |
| Description | p53-induced gene 3 proteinquinone oxidoreductase PIG3quinone oxidoreductase homolog | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605171 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000115129 | ||
| HPRD : 05527 | ||
| Vega : OTTHUMG00000090817 | ||
| Protein | UniProt: Q53FA7 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TP53I3 | |
| BioGPS: 9540 | ||
| Pathway | NCI Pathway Interaction Database: TP53I3 | |
| KEGG: TP53I3 | ||
| REACTOME: TP53I3 | ||
| Pathway Commons: TP53I3 | ||
| Context | iHOP: TP53I3 | |
| ligand binding site mutation search in PubMed: TP53I3 | ||
| UCL Cancer Institute: TP53I3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006739 | NADP metabolic process | 19349281 |
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| Ligand binding site mutations for TP53I3 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I217,Y221 | G219R | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TP53I3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | I217 | G219R | -0.8440513 | Y221 | G219R | -0.8440513 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TP53I3 from PDB |
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| Differential gene expression and gene-gene network for TP53I3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TP53I3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007097 | Carcinoma | 2 | Biomarker |
| umls:C0024667 | Mammary Neoplasms, Animal | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TP53I3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TP53I3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NAP | NADP ZWITTERION | 2oby | B | I217 | NAP | NADP ZWITTERION | 2oby | A | I217 Y221 | NAP | NADP ZWITTERION | 2oby | C | I217 Y221 | NAP | NADP ZWITTERION | 2oby | E | I217 Y221 | NAP | NADP ZWITTERION | 2oby | D | Y221 |
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| Conservation information for LBS of TP53I3 |
| Multiple alignments for Q53FA7 in multiple species |
| LBS | AA sequence | # species | Species |
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