mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL33
Gene summary
Basic gene Info.Gene symbolMRPL33
Gene namemitochondrial ribosomal protein L33
SynonymsC2orf1|L33mt|MRP-L33|RPL33L
CytomapUCSC genome browser: 2p21
Type of geneprotein-coding
RefGenesNM_004891.3,
NM_145330.2,
Description39S ribosomal protein L33, mitochondrial
Modification date20141207
dbXrefs MIM : 610059
HGNC : HGNC
Ensembl : ENSG00000243147
HPRD : 14753
Vega : OTTHUMG00000097795
ProteinUniProt: O75394
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL33
BioGPS: 9553
PathwayNCI Pathway Interaction Database: MRPL33
KEGG: MRPL33
REACTOME: MRPL33
Pathway Commons: MRPL33
ContextiHOP: MRPL33
ligand binding site mutation search in PubMed: MRPL33
UCL Cancer Institute: MRPL33
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


Top
Ligand binding site mutations for MRPL33

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R19R19TBLCA1
L41L41PCOAD1
R63R63CCOAD1
R63R63CSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for MRPL33
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R19R19T-1.1796362
R63R63C-0.79602321
L41L41P-0.38799245
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL33 from PDB

Top
Differential gene expression and gene-gene network for MRPL33
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL33 and the right PPI network was created from samples without mutations in the LBS of MRPL33. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for MRPL33
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for MRPL33
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL33 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7y1R19 L41 R63


Top
Conservation information for LBS of MRPL33
Multiple alignments for O75394 in multiple species
LBSAA sequence# speciesSpecies
C29AGTGFCFNTKR1Homo sapiens
C29AGTGFSFNTKR1Bos taurus
C29AGTGFSFNHKR1Mus musculus
F30GTGFCFNTKRN1Homo sapiens
F30GTGFSFNTKRS1Bos taurus
F30GTGFSFNHKRS1Mus musculus
H45KLTLLHYDPVV2Homo sapiens, Bos taurus
H45KLSLLHYDPIV1Mus musculus
I62VEQKKIRSL2Bos taurus, Mus musculus
I62VEKKKIRSL1Homo sapiens
K14AKSKSKTILVK2Bos taurus, Mus musculus
K14AKSKSKNILVR1Homo sapiens
L41RLREKLTLLHY1Homo sapiens
L41RLWEKLTLLHY1Bos taurus
L41RLREKLSLLHY1Mus musculus
L43REKLTLLHYDP1Homo sapiens
L43WEKLTLLHYDP1Bos taurus
L43REKLSLLHYDP1Mus musculus
L44EKLTLLHYDPV2Homo sapiens, Bos taurus
L44EKLSLLHYDPI1Mus musculus
N15KSKSKNILVRM1Homo sapiens
N15KSKSKTILVKM1Bos taurus
N15KSKSKTILVKL1Mus musculus
N31TGFCFNTKRNR1Homo sapiens
N31TGFSFNTKRSR1Bos taurus
N31TGFSFNHKRSR1Mus musculus
R19KNILVRMVSEA1Homo sapiens
R19KTILVKMVSQA1Bos taurus
R19KTILVKLVSQA1Mus musculus
R53PVVKQRVLFVE1Homo sapiens
R53PVVKKKVLFVE1Bos taurus
R53PIVNKKVLFVE1Mus musculus
R63EQKKIRSL2Bos taurus, Mus musculus
R63EKKKIRSL1Homo sapiens
T32GFCFNTKRNRL1Homo sapiens
T32GFSFNTKRSRL1Bos taurus
T32GFSFNHKRSRL1Mus musculus
Y46LTLLHYDPVVK2Homo sapiens, Bos taurus
Y46LSLLHYDPIVN1Mus musculus


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas