mutLBSgeneDB |
Gene summary for RNF144A |
![]() |
Basic gene Info. | Gene symbol | RNF144A |
Gene name | ring finger protein 144A | |
Synonyms | RNF144|UBCE7IP4 | |
Cytomap | UCSC genome browser: 2p25.2 | |
Type of gene | protein-coding | |
RefGenes | NM_014746.4, | |
Description | UbcM4-interacting protein 4probable E3 ubiquitin-protein ligase RNF144Aring finger protein 144ubiquitin conjugating enzyme 7 interacting protein 4ubiquitin-conjugating enzyme 7-interacting protein 4 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000151692 | ||
HPRD : 11510 | ||
Vega : OTTHUMG00000090353 | ||
Protein | UniProt: P50876 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RNF144A | |
BioGPS: 9781 | ||
Pathway | NCI Pathway Interaction Database: RNF144A | |
KEGG: RNF144A | ||
REACTOME: RNF144A | ||
Pathway Commons: RNF144A | ||
Context | iHOP: RNF144A | |
ligand binding site mutation search in PubMed: RNF144A | ||
UCL Cancer Institute: RNF144A | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for RNF144A |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | C43 | T44I | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for RNF144A |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C43 | T44I | -0.39730599 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for RNF144A |
![]() |
![]() |
Top |
Top |
Phenotype information for RNF144A |
![]() |
Disease ID | Disease name | # PubMed | Association type |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for RNF144A |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of RNF144A |
![]() |
LBS | AA sequence | # species | Species | C20 | DPLVSCKLCLG | 3 | Homo sapiens, Danio rerio, Mus musculus | C20 | EPLVSCKLCLG | 1 | Xenopus tropicalis | C23 | VSCKLCLGEYP | 2 | Homo sapiens, Mus musculus | C23 | VSCKLCLGEFP | 1 | Danio rerio | C23 | VSCKLCLGEYT | 1 | Xenopus tropicalis | C43 | CQCIFCTLCLK | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | C43 | CQCVFCTMCLK | 1 | Danio rerio | C46 | IFCTLCLKQYV | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | C46 | VFCTMCLKQYV | 1 | Danio rerio |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |