mutLBSgeneDB |
Gene summary for MRPL19 |
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Basic gene Info. | Gene symbol | MRPL19 |
Gene name | mitochondrial ribosomal protein L19 | |
Synonyms | L19mt|MRP-L15|MRP-L19|MRPL15|RLX1|RPML15 | |
Cytomap | UCSC genome browser: 2p11.1-q11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_014763.3, | |
Description | 39S ribosomal protein L15, mitochondrial39S ribosomal protein L19, mitochondrialL15mt | |
Modification date | 20141207 | |
dbXrefs | MIM : 611832 | |
HGNC : HGNC | ||
HPRD : 11370 | ||
Protein | UniProt: P49406 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MRPL19 | |
BioGPS: 9801 | ||
Pathway | NCI Pathway Interaction Database: MRPL19 | |
KEGG: MRPL19 | ||
REACTOME: MRPL19 | ||
Pathway Commons: MRPL19 | ||
Context | iHOP: MRPL19 | |
ligand binding site mutation search in PubMed: MRPL19 | ||
UCL Cancer Institute: MRPL19 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for MRPL19 |
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LBS | AAchange of nsSNV | Cancer type | # samples | R235 | R235H | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MRPL19 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R235 | R235H | -1.4886492 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for MRPL19 |
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Phenotype information for MRPL19 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C1458155 | Breast Neoplasms | 2 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MRPL19 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3j7y | Q | R235 |
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Conservation information for LBS of MRPL19 |
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LBS | AA sequence | # species | Species | E165 | VEICFELYNPR | 3 | Homo sapiens, Mus musculus, Bos taurus | E165 | VEVVYDLYNPT | 1 | Caenorhabditis elegans | E165 | MEVVYELYDPT | 1 | Drosophila melanogaster | G146 | SGRGLGATFIL | 1 | Homo sapiens | G146 | EKEGLLHQFTL | 1 | Caenorhabditis elegans | G146 | DRCGLRARFIL | 1 | Drosophila melanogaster | G146 | SGNGLGATFTL | 1 | Mus musculus | G146 | SGKGLGATFIL | 1 | Bos taurus | G85 | --PPRGRTNPL | 2 | Mus musculus, Bos taurus | G85 | --PRRGRTDPL | 1 | Homo sapiens | G85 | QSPVWNRRNAL | 1 | Caenorhabditis elegans | G85 | PDPKVEWRNLV | 1 | Drosophila melanogaster | K231 | PKPWSKRWERP | 3 | Homo sapiens, Mus musculus, Bos taurus | K231 | TPPWTRRWEVA | 1 | Caenorhabditis elegans | K231 | PRPWLERWERQ | 1 | Drosophila melanogaster | Q139 | LGICIQRSGRG | 1 | Homo sapiens | Q139 | VGICIRREKEG | 1 | Caenorhabditis elegans | Q139 | VGICINRDRCG | 1 | Drosophila melanogaster | Q139 | LGICIKRSGNG | 1 | Mus musculus | Q139 | LGICIQRSGKG | 1 | Bos taurus | R143 | IQRSGRGLGAT | 1 | Homo sapiens | R143 | IRREKEGLLHQ | 1 | Caenorhabditis elegans | R143 | INRDRCGLRAR | 1 | Drosophila melanogaster | R143 | IKRSGNGLGAT | 1 | Mus musculus | R143 | IQRSGKGLGAT | 1 | Bos taurus | R232 | KPWSKRWERPN | 2 | Homo sapiens, Mus musculus | R232 | PPWTRRWEVA- | 1 | Caenorhabditis elegans | R232 | RPWLERWERQ- | 1 | Drosophila melanogaster | R232 | KPWSKRWERPK | 1 | Bos taurus | R235 | SKRWERPNFNI | 2 | Homo sapiens, Mus musculus | R235 | TRRWEVA--SV | 1 | Caenorhabditis elegans | R235 | LERWERQ--NL | 1 | Drosophila melanogaster | R235 | SKRWERPKFNV | 1 | Bos taurus | R83 | FI--PPRGRTN | 2 | Mus musculus, Bos taurus | R83 | FI--PRRGRTD | 1 | Homo sapiens | R83 | FLQSPVWNRRN | 1 | Caenorhabditis elegans | R83 | FLPDPKVEWRN | 1 | Drosophila melanogaster | R84 | I--PPRGRTNP | 2 | Mus musculus, Bos taurus | R84 | I--PRRGRTDP | 1 | Homo sapiens | R84 | LQSPVWNRRNA | 1 | Caenorhabditis elegans | R84 | LPDPKVEWRNL | 1 | Drosophila melanogaster | R86 | -PPRGRTNPLK | 2 | Mus musculus, Bos taurus | R86 | -PRRGRTDPLK | 1 | Homo sapiens | R86 | SPVWNRRNALK | 1 | Caenorhabditis elegans | R86 | DPKVEWRNLVR | 1 | Drosophila melanogaster | S141 | ICIQRSGRGLG | 1 | Homo sapiens | S141 | ICIRREKEGLL | 1 | Caenorhabditis elegans | S141 | ICINRDRCGLR | 1 | Drosophila melanogaster | S141 | ICIKRSGNGLG | 1 | Mus musculus | S141 | ICIQRSGKGLG | 1 | Bos taurus | T148 | RGLGATFILRN | 1 | Homo sapiens | T148 | EGLLHQFTLRN | 1 | Caenorhabditis elegans | T148 | CGLRARFILRN | 1 | Drosophila melanogaster | T148 | NGLGATFTLRN | 1 | Mus musculus | T148 | KGLGATFILRN | 1 | Bos taurus | W260 | KEAQKWNQP-- | 1 | Homo sapiens | W260 | TQATPWFKRKL | 1 | Caenorhabditis elegans | W260 | LSAAKVQKP-- | 1 | Drosophila melanogaster | W260 | KEAQKWNKP-- | 1 | Mus musculus | W260 | KEAQKWSQP-- | 1 | Bos taurus |
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