mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL19
Gene summary
Basic gene Info.Gene symbolMRPL19
Gene namemitochondrial ribosomal protein L19
CytomapUCSC genome browser: 2p11.1-q11.2
Type of geneprotein-coding
Description39S ribosomal protein L15, mitochondrial39S ribosomal protein L19, mitochondrialL15mt
Modification date20141207
dbXrefs MIM : 611832
HPRD : 11370
ProteinUniProt: P49406
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL19
BioGPS: 9801
PathwayNCI Pathway Interaction Database: MRPL19
Pathway Commons: MRPL19
ContextiHOP: MRPL19
ligand binding site mutation search in PubMed: MRPL19
UCL Cancer Institute: MRPL19
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for MRPL19

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MRPL19
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL19 from PDB

Differential gene expression and gene-gene network for MRPL19
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL19 and the right PPI network was created from samples without mutations in the LBS of MRPL19. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MRPL19
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1458155Breast Neoplasms2Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MRPL19
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL19 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7yQR235

Conservation information for LBS of MRPL19
Multiple alignments for P49406 in multiple species
LBSAA sequence# speciesSpecies
E165VEICFELYNPR3Homo sapiens, Mus musculus, Bos taurus
E165VEVVYDLYNPT1Caenorhabditis elegans
E165MEVVYELYDPT1Drosophila melanogaster
G146SGRGLGATFIL1Homo sapiens
G146EKEGLLHQFTL1Caenorhabditis elegans
G146DRCGLRARFIL1Drosophila melanogaster
G146SGNGLGATFTL1Mus musculus
G146SGKGLGATFIL1Bos taurus
G85--PPRGRTNPL2Mus musculus, Bos taurus
G85--PRRGRTDPL1Homo sapiens
G85QSPVWNRRNAL1Caenorhabditis elegans
G85PDPKVEWRNLV1Drosophila melanogaster
K231PKPWSKRWERP3Homo sapiens, Mus musculus, Bos taurus
K231TPPWTRRWEVA1Caenorhabditis elegans
K231PRPWLERWERQ1Drosophila melanogaster
Q139LGICIQRSGRG1Homo sapiens
Q139VGICIRREKEG1Caenorhabditis elegans
Q139VGICINRDRCG1Drosophila melanogaster
Q139LGICIKRSGNG1Mus musculus
Q139LGICIQRSGKG1Bos taurus
R143IQRSGRGLGAT1Homo sapiens
R143IRREKEGLLHQ1Caenorhabditis elegans
R143INRDRCGLRAR1Drosophila melanogaster
R143IKRSGNGLGAT1Mus musculus
R143IQRSGKGLGAT1Bos taurus
R232KPWSKRWERPN2Homo sapiens, Mus musculus
R232PPWTRRWEVA-1Caenorhabditis elegans
R232RPWLERWERQ-1Drosophila melanogaster
R232KPWSKRWERPK1Bos taurus
R235SKRWERPNFNI2Homo sapiens, Mus musculus
R235TRRWEVA--SV1Caenorhabditis elegans
R235LERWERQ--NL1Drosophila melanogaster
R235SKRWERPKFNV1Bos taurus
R83FI--PPRGRTN2Mus musculus, Bos taurus
R83FI--PRRGRTD1Homo sapiens
R83FLQSPVWNRRN1Caenorhabditis elegans
R83FLPDPKVEWRN1Drosophila melanogaster
R84I--PPRGRTNP2Mus musculus, Bos taurus
R84I--PRRGRTDP1Homo sapiens
R84LQSPVWNRRNA1Caenorhabditis elegans
R84LPDPKVEWRNL1Drosophila melanogaster
R86-PPRGRTNPLK2Mus musculus, Bos taurus
R86-PRRGRTDPLK1Homo sapiens
R86SPVWNRRNALK1Caenorhabditis elegans
R86DPKVEWRNLVR1Drosophila melanogaster
S141ICIQRSGRGLG1Homo sapiens
S141ICIRREKEGLL1Caenorhabditis elegans
S141ICINRDRCGLR1Drosophila melanogaster
S141ICIKRSGNGLG1Mus musculus
S141ICIQRSGKGLG1Bos taurus
T148RGLGATFILRN1Homo sapiens
T148EGLLHQFTLRN1Caenorhabditis elegans
T148CGLRARFILRN1Drosophila melanogaster
T148NGLGATFTLRN1Mus musculus
T148KGLGATFILRN1Bos taurus
W260KEAQKWNQP--1Homo sapiens
W260TQATPWFKRKL1Caenorhabditis elegans
W260LSAAKVQKP--1Drosophila melanogaster
W260KEAQKWNKP--1Mus musculus
W260KEAQKWSQP--1Bos taurus

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