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mutLBSgeneDB |
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| Gene summary for MRPL19 |
 Gene summary |
| Basic gene Info. | Gene symbol | MRPL19 |
| Gene name | mitochondrial ribosomal protein L19 | |
| Synonyms | L19mt|MRP-L15|MRP-L19|MRPL15|RLX1|RPML15 | |
| Cytomap | UCSC genome browser: 2p11.1-q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014763.3, | |
| Description | 39S ribosomal protein L15, mitochondrial39S ribosomal protein L19, mitochondrialL15mt | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611832 | |
| HGNC : HGNC | ||
| HPRD : 11370 | ||
| Protein | UniProt: P49406 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MRPL19 | |
| BioGPS: 9801 | ||
| Pathway | NCI Pathway Interaction Database: MRPL19 | |
| KEGG: MRPL19 | ||
| REACTOME: MRPL19 | ||
| Pathway Commons: MRPL19 | ||
| Context | iHOP: MRPL19 | |
| ligand binding site mutation search in PubMed: MRPL19 | ||
| UCL Cancer Institute: MRPL19 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for MRPL19 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R235 | R235H | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MRPL19 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R235 | R235H | -1.4886492 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MRPL19 from PDB |
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| Differential gene expression and gene-gene network for MRPL19 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MRPL19 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1458155 | Breast Neoplasms | 2 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MRPL19 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MRPL19 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3j7y | Q | R235 |
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| Conservation information for LBS of MRPL19 |
| Multiple alignments for P49406 in multiple species |
| LBS | AA sequence | # species | Species | E165 | VEICFELYNPR | 3 | Homo sapiens, Mus musculus, Bos taurus | E165 | VEVVYDLYNPT | 1 | Caenorhabditis elegans | E165 | MEVVYELYDPT | 1 | Drosophila melanogaster | G146 | SGRGLGATFIL | 1 | Homo sapiens | G146 | EKEGLLHQFTL | 1 | Caenorhabditis elegans | G146 | DRCGLRARFIL | 1 | Drosophila melanogaster | G146 | SGNGLGATFTL | 1 | Mus musculus | G146 | SGKGLGATFIL | 1 | Bos taurus | G85 | --PPRGRTNPL | 2 | Mus musculus, Bos taurus | G85 | --PRRGRTDPL | 1 | Homo sapiens | G85 | QSPVWNRRNAL | 1 | Caenorhabditis elegans | G85 | PDPKVEWRNLV | 1 | Drosophila melanogaster | K231 | PKPWSKRWERP | 3 | Homo sapiens, Mus musculus, Bos taurus | K231 | TPPWTRRWEVA | 1 | Caenorhabditis elegans | K231 | PRPWLERWERQ | 1 | Drosophila melanogaster | Q139 | LGICIQRSGRG | 1 | Homo sapiens | Q139 | VGICIRREKEG | 1 | Caenorhabditis elegans | Q139 | VGICINRDRCG | 1 | Drosophila melanogaster | Q139 | LGICIKRSGNG | 1 | Mus musculus | Q139 | LGICIQRSGKG | 1 | Bos taurus | R143 | IQRSGRGLGAT | 1 | Homo sapiens | R143 | IRREKEGLLHQ | 1 | Caenorhabditis elegans | R143 | INRDRCGLRAR | 1 | Drosophila melanogaster | R143 | IKRSGNGLGAT | 1 | Mus musculus | R143 | IQRSGKGLGAT | 1 | Bos taurus | R232 | KPWSKRWERPN | 2 | Homo sapiens, Mus musculus | R232 | PPWTRRWEVA- | 1 | Caenorhabditis elegans | R232 | RPWLERWERQ- | 1 | Drosophila melanogaster | R232 | KPWSKRWERPK | 1 | Bos taurus | R235 | SKRWERPNFNI | 2 | Homo sapiens, Mus musculus | R235 | TRRWEVA--SV | 1 | Caenorhabditis elegans | R235 | LERWERQ--NL | 1 | Drosophila melanogaster | R235 | SKRWERPKFNV | 1 | Bos taurus | R83 | FI--PPRGRTN | 2 | Mus musculus, Bos taurus | R83 | FI--PRRGRTD | 1 | Homo sapiens | R83 | FLQSPVWNRRN | 1 | Caenorhabditis elegans | R83 | FLPDPKVEWRN | 1 | Drosophila melanogaster | R84 | I--PPRGRTNP | 2 | Mus musculus, Bos taurus | R84 | I--PRRGRTDP | 1 | Homo sapiens | R84 | LQSPVWNRRNA | 1 | Caenorhabditis elegans | R84 | LPDPKVEWRNL | 1 | Drosophila melanogaster | R86 | -PPRGRTNPLK | 2 | Mus musculus, Bos taurus | R86 | -PRRGRTDPLK | 1 | Homo sapiens | R86 | SPVWNRRNALK | 1 | Caenorhabditis elegans | R86 | DPKVEWRNLVR | 1 | Drosophila melanogaster | S141 | ICIQRSGRGLG | 1 | Homo sapiens | S141 | ICIRREKEGLL | 1 | Caenorhabditis elegans | S141 | ICINRDRCGLR | 1 | Drosophila melanogaster | S141 | ICIKRSGNGLG | 1 | Mus musculus | S141 | ICIQRSGKGLG | 1 | Bos taurus | T148 | RGLGATFILRN | 1 | Homo sapiens | T148 | EGLLHQFTLRN | 1 | Caenorhabditis elegans | T148 | CGLRARFILRN | 1 | Drosophila melanogaster | T148 | NGLGATFTLRN | 1 | Mus musculus | T148 | KGLGATFILRN | 1 | Bos taurus | W260 | KEAQKWNQP-- | 1 | Homo sapiens | W260 | TQATPWFKRKL | 1 | Caenorhabditis elegans | W260 | LSAAKVQKP-- | 1 | Drosophila melanogaster | W260 | KEAQKWNKP-- | 1 | Mus musculus | W260 | KEAQKWSQP-- | 1 | Bos taurus |
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