mutLBSgeneDB |
Gene summary for CDK1 |
Gene summary |
Basic gene Info. | Gene symbol | CDK1 |
Gene name | cyclin-dependent kinase 1 | |
Synonyms | CDC2|CDC28A|P34CDC2 | |
Cytomap | UCSC genome browser: 10q21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001170406.1, NM_001170407.1,NM_001786.4,NM_033379.4,NM_001130829.1, | |
Description | cell cycle controller CDC2cell division control protein 2 homologcell division cycle 2, G1 to S and G2 to Mcell division protein kinase 1p34 protein kinase | |
Modification date | 20141222 | |
dbXrefs | MIM : 116940 | |
HGNC : HGNC | ||
Ensembl : ENSG00000170312 | ||
HPRD : 00302 | ||
Vega : OTTHUMG00000018290 | ||
Protein | UniProt: P06493 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CDK1 | |
BioGPS: 983 | ||
Pathway | NCI Pathway Interaction Database: CDK1 | |
KEGG: CDK1 | ||
REACTOME: CDK1 | ||
Pathway Commons: CDK1 | ||
Context | iHOP: CDK1 | |
ligand binding site mutation search in PubMed: CDK1 | ||
UCL Cancer Institute: CDK1 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0018105 | peptidyl-serine phosphorylation | 11298763 | GO:0018107 | peptidyl-threonine phosphorylation | 11298763 | GO:0034501 | protein localization to kinetochore | 18195732 | GO:0043066 | negative regulation of apoptotic process | 11069302 |
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Ligand binding site mutations for CDK1 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | L135 | I136N | LUAD | 1 | V18 | V18L | LUSC | 1 | L135 | L134F | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CDK1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | L135 | I136N | -1.6016167 | L135 | L134F | -0.98830569 | V18 | V18L | -0.42265621 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CDK1 from PDB |
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Differential gene expression and gene-gene network for CDK1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CDK1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0079744 | Lymphoma, Large B-Cell, Diffuse | 2 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CDK1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB02052 | Indirubin-3'-Monoxime | Small molecule | |
Experimental | DB02116 | Olomoucine | Small molecule | |
Experimental | DB02950 | Hymenialdisine | Small molecule | |
Experimental | DB03428 | SU9516 | Small molecule | |
Experimental|investigational | DB03496 | Flavopiridol | Small molecule | |
Experimental | DB04014 | Alsterpaullone | Small molecule | |
Investigational | DB05037 | AT7519 | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CDK1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | LZ9 | {[(2,6-DIFLUOROPHENYL)CARBONYL]AMINO}-N-(4-FLUOROPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE | 4y72 | A | V18 L135 |
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Conservation information for LBS of CDK1 |
Multiple alignments for P06493 in multiple species |
LBS | AA sequence | # species | Species | A31 | TGQVVAMKKIR | 3 | Homo sapiens, Gallus gallus, Bos taurus | A31 | TGQIVAMKKIR | 3 | Drosophila melanogaster, Mus musculus, Rattus norvegicus | A31 | TNAMVAMKKIR | 1 | Caenorhabditis elegans | D146 | TIKLADFGLAR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D146 | AIKLADFGLAR | 1 | Caenorhabditis elegans | D146 | LIKVADFGLGR | 1 | Drosophila melanogaster | D146 | VIKLADFGLAR | 1 | Gallus gallus | D86 | EFLSMDLKKYL | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | D86 | EFLSFDLKRYM | 1 | Caenorhabditis elegans | D86 | EFLSMDLKKYM | 1 | Drosophila melanogaster | E81 | LYLIFEFLSMD | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | E81 | LFLIFEFLSFD | 1 | Caenorhabditis elegans | E81 | IYLIFEFLSMD | 1 | Drosophila melanogaster | F80 | RLYLIFEFLSM | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | F80 | RLFLIFEFLSF | 1 | Caenorhabditis elegans | F80 | RIYLIFEFLSM | 1 | Drosophila melanogaster | F82 | YLIFEFLSMDL | 6 | Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | F82 | FLIFEFLSFDL | 1 | Caenorhabditis elegans | I10 | TKIEKIGEGTY | 3 | Homo sapiens, Gallus gallus, Bos taurus | I10 | IKIEKIGEGTY | 2 | Mus musculus, Rattus norvegicus | I10 | TKLEKIGEGTY | 1 | Caenorhabditis elegans | I10 | EKIEKIGEGTY | 1 | Drosophila melanogaster | K33 | QVVAMKKIRLE | 3 | Homo sapiens, Gallus gallus, Bos taurus | K33 | QIVAMKKIRLE | 3 | Drosophila melanogaster, Mus musculus, Rattus norvegicus | K33 | AMVAMKKIRLE | 1 | Caenorhabditis elegans | K89 | SMDLKKYLDSI | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K89 | SFDLKRYMDQL | 1 | Caenorhabditis elegans | K89 | SMDLKKYMDSL | 1 | Drosophila melanogaster | K89 | SMDLKKYLDTI | 1 | Gallus gallus | L135 | KPQNLLIDDKG | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | L135 | KPQNLLVDNNG | 1 | Caenorhabditis elegans | L135 | KPQNLLIDKSG | 1 | Drosophila melanogaster | L83 | LIFEFLSMDLK | 6 | Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | L83 | LIFEFLSFDLK | 1 | Caenorhabditis elegans | S84 | IFEFLSMDLKK | 6 | Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | S84 | IFEFLSFDLKR | 1 | Caenorhabditis elegans | V18 | GTYGVVYKGRH | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | V18 | GTYGVVYKGKN | 1 | Caenorhabditis elegans | V18 | GTYGVVYKGRN | 1 | Drosophila melanogaster | V64 | RHPNIVSLQDV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | V64 | QHPNVVGLEAV | 1 | Caenorhabditis elegans | V64 | KHENIVCLEDV | 1 | Drosophila melanogaster | V64 | HHPNIVCLQDV | 1 | Gallus gallus | Y15 | IGEGTYGVVYK | 7 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus |
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