mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CDC20
Gene summary
Basic gene Info.Gene symbolCDC20
Gene namecell division cycle 20
CytomapUCSC genome browser: 1p34.1
Type of geneprotein-coding
DescriptionCDC20 cell division cycle 20 homologcell division cycle 20 homologcell division cycle protein 20 homolog
Modification date20141207
dbXrefs MIM : 603618
Ensembl : ENSG00000117399
HPRD : 04686
Vega : OTTHUMG00000007420
ProteinUniProt: Q12834
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CDC20
BioGPS: 991
PathwayNCI Pathway Interaction Database: CDC20
Pathway Commons: CDC20
ContextiHOP: CDC20
ligand binding site mutation search in PubMed: CDC20
UCL Cancer Institute: CDC20
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process17443180
GO:0051488activation of anaphase-promoting complex activity11459826

Ligand binding site mutations for CDC20
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CDC20
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CDC20 from PDB

Differential gene expression and gene-gene network for CDC20
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CDC20 and the right PPI network was created from samples without mutations in the LBS of CDC20. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CDC20
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0017661Glomerulonephritis, IGA1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CDC20
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CDC20 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (LEU,SER,LYS,GLU,ASN,VAL,GLN)4ggdAR445
IIIPeptide ligand (GLU,LEU,SER,LYS,GLU,ASN,VAL,GLN)4ggdBR445

Conservation information for LBS of CDC20
Multiple alignments for Q12834 in multiple species
LBSAA sequence# speciesSpecies
A357TQHQGAVKAVA3Homo sapiens, Mus musculus, Rattus norvegicus
A357KTHTAAVKALS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A357TNHNAAVKAVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D177PDRILDAPEIR3Homo sapiens, Mus musculus, Rattus norvegicus
D177PERILDAPGFQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D177PERVLDAPGII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D184PEIRNDYYLNL3Homo sapiens, Mus musculus, Rattus norvegicus
D184PGFQDDFYLNL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D184PGIIDDYYLNL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G376LATGGGTSDRH3Homo sapiens, Mus musculus, Rattus norvegicus
G376LASGGGQTDKH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G376LATGGGTMDKQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I216AGSGDILQLLQ2Mus musculus, Rattus norvegicus
I216ASSGDILQLLQ1Homo sapiens
I216ATTGDVSLLTD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I216ADSGSVSALAE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L176LPDRILDAPEI3Homo sapiens, Mus musculus, Rattus norvegicus
L176NPERILDAPGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L176TPERVLDAPGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L202VLAVALDNSVY3Homo sapiens, Mus musculus, Rattus norvegicus
L202VLAIALDTALY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L202VVAVALERNVY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N329LASGGNDNIVN2Mus musculus, Rattus norvegicus
N329LASGGNDNLVN1Homo sapiens
N329LASGGNDNTVM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N329LASGGNDNVVQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N331SGGNDNIVNVW2Mus musculus, Rattus norvegicus
N331SGGNDNLVNVW1Homo sapiens
N331SGGNDNTVMIW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N331SGGNDNVVQIW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q310LSGHSQEVCGL3Homo sapiens, Mus musculus, Rattus norvegicus
Q310WAEHTGEVCGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q310LQGHSSEVCGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q401VDVHSQVCSIL2Mus musculus, Rattus norvegicus
Q401VDAHSQVCSIL1Homo sapiens
Q401INTGSQVSSLH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q401VDAGSQVTSLI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R445KGHTSRVLSLT1Homo sapiens
R445KGHTARVLGLT1Mus musculus
R445KGHTARVLSLT1Rattus norvegicus
R445HAHEARICCSQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R445PAHDTRVLYSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T377ATGGGTSDRHI3Homo sapiens, Mus musculus, Rattus norvegicus
T377ASGGGQTDKHI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T377ATGGGTMDKQI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W209NSVYLWNAGSG2Mus musculus, Rattus norvegicus
W209NSVYLWSASSG1Homo sapiens
W209TALYLWNATTG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W209RNVYVWNADSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y185EIRNDYYLNLV3Homo sapiens, Mus musculus, Rattus norvegicus
Y185GFQDDFYLNLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y185GIIDDYYLNLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y186IRNDYYLNLVD3Homo sapiens, Mus musculus, Rattus norvegicus
Y186FQDDFYLNLLS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y186IIDDYYLNLLD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y207LDNSVYLWNAG2Mus musculus, Rattus norvegicus
Y207LDNSVYLWSAS1Homo sapiens
Y207LDTALYLWNAT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y207LERNVYVWNAD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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