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mutLBSgeneDB |
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| Gene summary for CDC20 |
 Gene summary |
| Basic gene Info. | Gene symbol | CDC20 |
| Gene name | cell division cycle 20 | |
| Synonyms | CDC20A|bA276H19.3|p55CDC | |
| Cytomap | UCSC genome browser: 1p34.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001255.2, | |
| Description | CDC20 cell division cycle 20 homologcell division cycle 20 homologcell division cycle protein 20 homolog | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603618 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000117399 | ||
| HPRD : 04686 | ||
| Vega : OTTHUMG00000007420 | ||
| Protein | UniProt: Q12834 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CDC20 | |
| BioGPS: 991 | ||
| Pathway | NCI Pathway Interaction Database: CDC20 | |
| KEGG: CDC20 | ||
| REACTOME: CDC20 | ||
| Pathway Commons: CDC20 | ||
| Context | iHOP: CDC20 | |
| ligand binding site mutation search in PubMed: CDC20 | ||
| UCL Cancer Institute: CDC20 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 17443180 | GO:0051488 | activation of anaphase-promoting complex activity | 11459826 |
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| Ligand binding site mutations for CDC20 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y207,W209 | L208M | COAD | 1 | R445 | R445Q | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CDC20 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | W209 | L208M | -0.94813925 | Y207 | L208M | -0.94813925 | R445 | R445Q | -0.68178091 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CDC20 from PDB |
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| Differential gene expression and gene-gene network for CDC20 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CDC20 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0017661 | Glomerulonephritis, IGA | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CDC20 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CDC20 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (LEU,SER,LYS,GLU,ASN,VAL,GLN) | 4ggd | A | R445 | III | Peptide ligand (GLU,LEU,SER,LYS,GLU,ASN,VAL,GLN) | 4ggd | B | R445 | WR7 | APCIN | 2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL [(1R)-2,2,2- TRICHLORO-1-(PYRIMIDIN-2-YLAMINO)ETHYL]CARBAMATE | 4n14 | A | Y207 W209 |
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| Conservation information for LBS of CDC20 |
| Multiple alignments for Q12834 in multiple species |
| LBS | AA sequence | # species | Species | A357 | TQHQGAVKAVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A357 | KTHTAAVKALS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A357 | TNHNAAVKAVA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D177 | PDRILDAPEIR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D177 | PERILDAPGFQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D177 | PERVLDAPGII | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D184 | PEIRNDYYLNL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D184 | PGFQDDFYLNL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D184 | PGIIDDYYLNL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G376 | LATGGGTSDRH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G376 | LASGGGQTDKH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G376 | LATGGGTMDKQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I216 | AGSGDILQLLQ | 2 | Mus musculus, Rattus norvegicus | I216 | ASSGDILQLLQ | 1 | Homo sapiens | I216 | ATTGDVSLLTD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I216 | ADSGSVSALAE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L176 | LPDRILDAPEI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L176 | NPERILDAPGF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L176 | TPERVLDAPGI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L202 | VLAVALDNSVY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L202 | VLAIALDTALY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L202 | VVAVALERNVY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N329 | LASGGNDNIVN | 2 | Mus musculus, Rattus norvegicus | N329 | LASGGNDNLVN | 1 | Homo sapiens | N329 | LASGGNDNTVM | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N329 | LASGGNDNVVQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N331 | SGGNDNIVNVW | 2 | Mus musculus, Rattus norvegicus | N331 | SGGNDNLVNVW | 1 | Homo sapiens | N331 | SGGNDNTVMIW | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N331 | SGGNDNVVQIW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q310 | LSGHSQEVCGL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q310 | WAEHTGEVCGL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q310 | LQGHSSEVCGL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q401 | VDVHSQVCSIL | 2 | Mus musculus, Rattus norvegicus | Q401 | VDAHSQVCSIL | 1 | Homo sapiens | Q401 | INTGSQVSSLH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q401 | VDAGSQVTSLI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R445 | KGHTSRVLSLT | 1 | Homo sapiens | R445 | KGHTARVLGLT | 1 | Mus musculus | R445 | KGHTARVLSLT | 1 | Rattus norvegicus | R445 | HAHEARICCSQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R445 | PAHDTRVLYSA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T377 | ATGGGTSDRHI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T377 | ASGGGQTDKHI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T377 | ATGGGTMDKQI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | W209 | NSVYLWNAGSG | 2 | Mus musculus, Rattus norvegicus | W209 | NSVYLWSASSG | 1 | Homo sapiens | W209 | TALYLWNATTG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | W209 | RNVYVWNADSG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y185 | EIRNDYYLNLV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y185 | GFQDDFYLNLL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y185 | GIIDDYYLNLL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y186 | IRNDYYLNLVD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y186 | FQDDFYLNLLS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y186 | IIDDYYLNLLD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y207 | LDNSVYLWNAG | 2 | Mus musculus, Rattus norvegicus | Y207 | LDNSVYLWSAS | 1 | Homo sapiens | Y207 | LDTALYLWNAT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y207 | LERNVYVWNAD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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