mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for KIAA0020
Gene summary
Basic gene Info.Gene symbolKIAA0020
Gene nameKIAA0020
CytomapUCSC genome browser: 9p24.2
Type of geneprotein-coding
DescriptionHBV X-transactivated gene 5 proteinHBV XAg-transactivated protein 5minor histocompatibility antigen HA-8penguin homologprotein 5 transactivated by hepatitis B virus X antigen (HBxAg)pumilio domain-containing protein KIAA0020
Modification date20141207
dbXrefs MIM : 609960
Ensembl : ENSG00000080608
HPRD : 08822
Vega : OTTHUMG00000019450
ProteinUniProt: Q15397
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KIAA0020
BioGPS: 9933
PathwayNCI Pathway Interaction Database: KIAA0020
Pathway Commons: KIAA0020
ContextiHOP: KIAA0020
ligand binding site mutation search in PubMed: KIAA0020
UCL Cancer Institute: KIAA0020
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for KIAA0020

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for KIAA0020
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KIAA0020 from PDB

Differential gene expression and gene-gene network for KIAA0020
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of KIAA0020 and the right PPI network was created from samples without mutations in the LBS of KIAA0020. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for KIAA0020
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for KIAA0020
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KIAA0020 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids4wzwAE457
NUCNucleic Acids4wzwAV455

Conservation information for LBS of KIAA0020
Multiple alignments for Q15397 in multiple species
LBSAA sequence# speciesSpecies
E457AHTVREIIEVL1Homo sapiens
E457RYLSHDDLAAL1Arabidopsis thaliana
E457RGIDKREITFL1Caenorhabditis elegans
E457AHTVPELIELL1Mus musculus
H362YLAHTHDGARV2Homo sapiens, Mus musculus
H362RMVHTRDGSRL1Arabidopsis thaliana
H362EFIHTPDGAKL1Caenorhabditis elegans
I458HTVREIIEVL-1Homo sapiens
I458YLSHDDLAALD1Arabidopsis thaliana
I458GIDKREITFL-1Caenorhabditis elegans
I458HTVPELIELL-1Mus musculus
K220SRNIVKKFLMY2Homo sapiens, Mus musculus
K220AVHFIQKMLDG1Arabidopsis thaliana
K220SKFFVKKMLKN1Caenorhabditis elegans
K440DKYGRKVLLYL2Homo sapiens, Mus musculus
K440DKNGRRPLLQL1Arabidopsis thaliana
K440DDWGEKVIHYL1Caenorhabditis elegans
R268AILEQRNMLTE2Homo sapiens, Mus musculus
R268GSAAQKQELLA1Arabidopsis thaliana
R268ANAHQRYNIIT1Caenorhabditis elegans
R366THDGARVAMHC2Homo sapiens, Mus musculus
R366TRDGSRLAMLS1Arabidopsis thaliana
R366TPDGAKLAIKL1Caenorhabditis elegans
V455DPAHTVREIIE1Homo sapiens
V455SSRYLSHDDLA1Arabidopsis thaliana
V455DGRGIDKREIT1Caenorhabditis elegans
V455DPAHTVPELIE1Mus musculus
Y399VANGQYSHLVL2Homo sapiens, Mus musculus
Y399MAFDQFGSMVL1Arabidopsis thaliana
Y399AAMEHYGHRVL1Caenorhabditis elegans

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